1309 Results for "

PI3K-

" in MedChemExpress (MCE) Product Catalog:

Products (1309)

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Pectolinarigenin (Standard)

Cat. No.: HY-N0493R

CAS No.: 520-12-7

Category:

Flavonoids Flavones Campylotropis hirtella (Franch.) Schindl. Phenols Polyphenols Plants Compositae Extract

Target:

Reference Standards COX Lipoxygenase NF-κB p38 MAPK ERK HIF/HIF Prolyl-Hydroxylase Keap1-Nrf2 PI3K Apoptosis Autophagy

Pectolinarigenin (Standard) is the analytical standard of Pectolinarigenin. This product is intended for research and analytical applications. Pectolinarigenin is an orally active dual inhibitor of COX-2/5-LOX with anti-inflammatory, antioxidant, antitumor and neuroprotective activities. Pectolinarigenin exerts neuroprotective and anti-inflammatory effects on astrocyte inflammation via the NFκB and MAPK pathways. Pectolinarigenin inhibits LPS-induced phosphorylation of ERK1/2, N-FκB and p38MAPK, directly inhibits the enzymatic activity or binding of COX-2, 5-LOX and HIF-1α, and reduces the level of XIAP. Pectolinarigenin modifies Keap1 to promote nuclear accumulation of Nrf2, induces ARE-mediated antioxidant enzyme expression, and possesses direct free radical scavenging activity. Pectolinarigenin reduces the release of NO, proinflammatory mediators and leukotrienes, and increases the level of IL-10. Pectolinarigenin induces G₂/M cell cycle arrest, apoptosis (Apoptosis) and autophagy (Autophagy) via the PI3K/AKT/mTOR signaling pathway. Pectolinarigenin reduces renal crystal deposition and inhibits melanin synthesis. Pectolinarigenin inhibits inflammation and alleviates allergy in mouse models of inflammation. Pectolinarigenin alleviates renal injury, inflammation and oxidative stress in mice by inhibiting HIF-1α activity. Pectolinarigenin can be used for the research of neurodegenerative diseases, inflammatory/allergic diseases, calcium oxalate nephrocalcinosis, gastric cancer, melasma, post-inflammatory diseases and chloasma.

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Anti-Breast Cancer Compound Library

Cat. No.: HY-L074

3,404 compounds

Breast cancer is the most frequent cancer among women, impacting 2.1 million women each year, and also causes the greatest number of cancer-related deaths among women. Surgery is usually the first type of treatment for breast cancer, which is usually followed by chemotherapy or radiotherapy or, in some cases, hormone or targeted therapies, especially for metastatic breast cancer (MBC).

Breast cancer is a heterogeneous disease, which is categorized into 3 major subtypes based on the presence or absence of molecular markers for estrogen or progesterone receptors and human epidermal growth factor 2 (ERBB2; formerly HER2): hormone receptor positive/ERBB2 negative (70% of patients), ERBB2 positive (15%-20%), and triple-negative (tumors lacking all 3 standard molecular markers; 15%). Different intrinsic subtypes exhibit different tumor behavior with different prognoses, and may require specific targeted therapies to maximize treatment effectiveness. Otherwise, some signaling pathways also play important roles in the development of breast cancer, such as NF-κB Signaling Pathway, TGF-beta Signaling Pathway, PI3K/AKT/mTOR signaling pathway and Notch Signaling Pathway. These signaling pathways offer ideal targets for development of new targeted therapies for breast cancer.

MCE supplies a unique collection of 3,404 compounds with identified and potential anti-breast cancer activity. MCE Anti-Breast Cancer Compound Library is a useful tool for anti-breast cancer drugs screening.

Jujuboside B

Cat. No.: HY-N0660

CAS No.: 55466-05-2

Category:

Cardiovascular Disease Triterpenes Terpenoids Plants Other Families Extract Disease Research Fields

Target:

Apoptosis PARP Caspase AMPK Autophagy VEGFR Keap1-Nrf2 STING 11β-HSD Ferroptosis PI3K Akt p38 MAPK ERK

Jujuboside B is a bioactive saponin component isolated from Ziziphi Spinosae Semen (sour jujube seed), with oral efficacy and blood-brain barrier permeability. Jujuboside B induces acute leukemia cell death and drives necroptosis apoptosis by activating the RIPK1/RIPK3/MLKL pathway. Jujuboside B upregulates the expression of NOXA, PARP and caspase-3, activates AMPK, inhibits the proliferation of breast cancer cells, and induces cell apoptosis and autophagy. Jujuboside B inhibits angiogenesis and tumor growth by blocking the VEGFR-2 signaling pathway. Jujuboside B alleviates liver injury in mice by regulating the Nrf2-STING signaling pathway . Jujuboside B alleviates liver injury by regulating anti-inflammatory responses and downregulating the expression of 11β-HSD2. Jujuboside B induces ferroptosis and overcomes radioresistance in non-small cell lung cancer via the PPARγ-ATF3-Gpx4 signaling pathway. Jujuboside B exerts inhibitory effects on platelet aggregation. Jujuboside B inhibits febrile seizures by suppressing the activity of AMPA receptors. Jujuboside B reverses chronic unpredictable mild stress-promoted tumor progression by blocking the PI3K/Akt and MAPK/ERK pathways and dephosphorylating CREB signaling. Jujuboside B is applicable to related studies on acute leukemia, breast cancer, PM_2.5-induced lung injury, hepatotoxicity, liver injury, colorectal cancer, non-small cell lung cancer, thromboembolic diseases, cardiovascular diseases associated with high platelet aggregation, febrile seizures, and depressive-like phenotypes ^[3] .

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Jujuboside B (Standard)

Cat. No.: HY-N0660R

CAS No.: 55466-05-2

Category:

Triterpenes Terpenoids Plants Other Families Extract

Target:

Reference Standards ERK p38 MAPK Akt PI3K 11β-HSD STING VEGFR Ferroptosis Autophagy Apoptosis Keap1-Nrf2 Caspase PARP AMPK

Jujuboside B (Standard) is the analytical standard of Jujuboside B. This product is intended for research and analytical applications. Jujuboside B is a bioactive saponin component isolated from Ziziphi Spinosae Semen (sour jujube seed), with oral efficacy and blood-brain barrier permeability. Jujuboside B induces acute leukemia cell death and drives necroptosis apoptosis by activating the RIPK1/RIPK3/MLKL pathway. Jujuboside B upregulates the expression of NOXA, PARP and caspase-3, activates AMPK, inhibits the proliferation of breast cancer cells, and induces cell apoptosis and autophagy. Jujuboside B inhibits angiogenesis and tumor growth by blocking the VEGFR-2 signaling pathway. Jujuboside B alleviates liver injury in mice by regulating the Nrf2-STING signaling pathway . Jujuboside B alleviates liver injury by regulating anti-inflammatory responses and downregulating the expression of 11β-HSD2. Jujuboside B induces ferroptosis and overcomes radioresistance in non-small cell lung cancer via the PPARγ-ATF3-Gpx4 signaling pathway. Jujuboside B exerts inhibitory effects on platelet aggregation. Jujuboside B inhibits febrile seizures by suppressing the activity of AMPA receptors. Jujuboside B reverses chronic unpredictable mild stress-promoted tumor progression by blocking the PI3K/Akt and MAPK/ERK pathways and dephosphorylating CREB signaling. Jujuboside B is applicable to related studies on acute leukemia, breast cancer, PM_2.5-induced lung injury, hepatotoxicity, liver injury, colorectal cancer, non-small cell lung cancer, thromboembolic diseases, cardiovascular diseases associated with high platelet aggregation, febrile seizures, and depressive-like phenotypes.

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PIK3CG Protein, Human (sf9, His, GST)

Cat. No.: HY-P703582

Purity: ≥ 85%, as determined by reducing SDS-PAGE.

Synonyms: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform; EC:2.7.1.137; EC:2.7.1.153; EC:2.7.1.154; PI3-kinase subunit gamma; PI3K-gamma; PI3Kgamma; PtdIns-3-kinase subunit gamma; Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kD

Species:

Human

Source:

Sf9 insect cells

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p85α/p110α Protein, Human (Active, H1047R, Biotinylated, sf9, Avi)

Cat. No.: HY-P703466

Purity: ≥ 90%, as determined by reducing SDS-PAGE.

Synonyms: PIK3R1; PI3-Kinase Subunit P85-Alpha; Phosphoinositide-3-Kinase Regulatory Subunit 1; PI3 Kinase-Associated P85; GRB1; CDNA FLJ44373 Fis, Clone TRACH3009455, Highly Similar To Phosphatidylinositol 3-Kinase Regulatory Subunit Alpha; Phosphatidylinositol 3-Kinase 85 KDa Regulatory Subunit Alpha; Phosphatidylinositol 3-Kinase, Regulatory Subunit, Polypeptide 1 (P85 Alpha); Phosphatidylinositol 3-Kinase Regulatory Subunit Alpha; Phosphatidylinositol 3-Kinase-Associated P-85 Alpha; P85-ALPHA; PtdIns-3-Kinase Regulatory Subunit P85-Alpha; P85alpha; Phosphoinositide-3-Kinase Regulatory Subunit; P85; PI3-Kinase Regulatory Subunit Alpha; Phosphoinositide-3-Kinase, Regulatory Subunit 1 (Alpha); PIK3R1/NR4A3 Fusion Protein; Phosphoinositide-3-Kinase Regulatory Subunit Alpha; NR4A3 Fusion; PtdIns-3-Kinase Regulatory Subunit Alpha; IMD36; Growth Factor Receptor Bound 1; AGM7; PI3K Regulatory Subunit Alpha; MHC class I antigen; MHC class I protein; Mamu-A1; Mamu-A

Species:

Human

Source:

Sf9 insect cells

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p85α/p110α Protein, Human (Active, Biotinylated, sf9, Avi)

Cat. No.: HY-P703467

Purity: ≥ 90%, as determined by reducing SDS-PAGE.

Species:

Human

Source:

Sf9 insect cells

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p85α/p110α Protein, Human (Active, E545K, Biotinylated, sf9, Avi)

Cat. No.: HY-P703469

Purity: ≥ 80%, as determined by reducing SDS-PAGE.

Species:

Human

Source:

Sf9 insect cells

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p85α/p110α Protein, Human (Active, H1047R, sf9, GST)

Cat. No.: HY-P706085

Purity: ≥ 85%, as determined by reducing SDS-PAGE.

Synonyms: MHC class I antigen; MHC class I protein; Mamu-A1; Mamu-A; PIK3R1; PI3-Kinase Subunit P85-Alpha; Phosphoinositide-3-Kinase Regulatory Subunit 1; PI3 Kinase-Associated P85; GRB1; CDNA FLJ44373 Fis, Clone TRACH3009455, Highly Similar To Phosphatidylinositol 3-Kinase Regulatory Subunit Alpha; Phosphatidylinositol 3-Kinase 85 KDa Regulatory Subunit Alpha; Phosphatidylinositol 3-Kinase, Regulatory Subunit, Polypeptide 1 (P85 Alpha); Phosphatidylinositol 3-Kinase Regulatory Subunit Alpha; Phosphatidylinositol 3-Kinase-Associated P-85 Alpha; P85-ALPHA; PtdIns-3-Kinase Regulatory Subunit P85-Alpha; P85alpha; Phosphoinositide-3-Kinase Regulatory Subunit; P85; PI3-Kinase Regulatory Subunit Alpha; Phosphoinositide-3-Kinase, Regulatory Subunit 1 (Alpha); PIK3R1/NR4A3 Fusion Protein; Phosphoinositide-3-Kinase Regulatory Subunit Alpha; NR4A3 Fusion; PtdIns-3-Kinase Regulatory Subunit Alpha; IMD36; Growth Factor Receptor Bound 1; AGM7; PI3K Regulatory Subunit Alpha

Species:

Human

Source:

Sf9 insect cells

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