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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
237 Results for "
low-affinity
" in MedChemExpress (MCE) Product Catalog:
Products (237)
237 Results for "low-affinity" in MCE Product Catalog:
Cat. No.: HY-16688B
CAS No.: 66611-27-6
Target:
Research Areas:
RU 24969 hemisuccinate is a preferential 5-HT1B agonist, with a Ki of 0.38 nM, but also displays appreciable affinity for the 5-HT1A receptor (Ki=2.5 nM), and has low affinity for other receptor sites in the brain. RU 24969 hemisuccinate could decrease fluid consumption and increase forward locomotion .
Cat. No.: HY-N16533
CAS No.: 263368-92-9
Target:
Cat. No.: HY-P10581A
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Research Areas:
Cat. No.: HY-P10582A
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Cat. No.: HY-10684R
CAS No.: 346688-38-8
Synonyms: ACR16 (Standard); ASP2314 (Standard); FR310826 (Standard)
Target:
Research Areas:
Pridopidine (Standard) is the analytical standard of Pridopidine. This product is intended for research and analytical applications. Pridopidine, a dopamine (DA) stabilizer, acts as a low affinity dopamine D2 receptor (D2R) antagonist. Pridopidine exerts high affinity towards sigma 1 receptor (S1R) with Ki between 70 and 80 nM, which is ~100× higher than its affinity toward D2R.
Cat. No.: HY-177790
CAS No.: 2096315-41-0
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Research Areas:
Orexin receptor antagonist 7 (Compound 34) is an antagonist of the orexin receptor (OX1R), with a Ki value of 4.05 nM. Orexin receptor antagonist 7 shows no detectable activity towards OX2R and has very low affinities for the three opioid receptors (μ, δ, κ) (Ki > 1,000 nM). Orexin receptor antagonist 7 can be used for research on opioid addiction .
Cat. No.: HY-182565
CAS No.: 1854997-77-5
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PSI-112 is a YO-class μPlm inhibitor, with IC50 values of 0.38 μM, 1.48 μM and 0.37 μM against the wild-type, F587A mutant and K607A mutant, respectively. PSI-112 shows low affinity for uPA. PSI-112 can be used in cancer research .
Cat. No.: HY-116222
CAS No.: 115103-48-5
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Research Areas:
A 53693 is a rigid catecholamine with selective adrenergic agonist activity. A 53693 has affinity for certain rat alpha-2 receptor subtypes. A 53693 shows high selectivity for alpha-2 receptors and, in contrast, has low affinity for alpha-1 receptors. A 53693 is used as a probe in biological studies to explore the molecular interactions of alpha agonist compounds .
Cat. No.: HY-124356
CAS No.: 147083-93-0
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Alcaftadine carboxylic acid is a broad-spectrum antihistamine compound with high affinity for histamine H1 and H2 receptors and low affinity for H4 receptors. Alcaftadine carboxylic acid has also demonstrated effects on modulating immune cell recruitment and stabilizing mast cells. Alcaftadine carboxylic acid is more effective than placebo in preventing ocular itching associated with allergic conjunctivitis and is at least as effective as olopatadine 0.01% .
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CHK1-IN-3 is a potent and selective CHK1 inhibitor with an IC50 of 0.4 nM. CHK1-IN-3 effectively inhibits the growth of malignant hematopathy cell lines and displays low affinity for hERG (IC50 > 40 μM). CHK1-IN-3 significantly suppresses the tumor growth in vivo. CHK1-IN-3 can be used for the study of hematologic malignancies .
Cat. No.: HY-106131
CAS No.: 114419-77-1
Synonyms: PD-123497
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Research Areas:
RSD-921 (PD-123497) is a potent Na + channel blocker with anti-arrhythmic activity. RSD-921 displays a low affinity for κ-opioid receptors and behaves as a weak κ-agonist in vitro. RSD 921 displays state-, time- and voltage-dependent block of the open state of cardiac, skeletal muscle and neuronal Na + channels expressed in Xenopus oocytes. RSD-921 can be used for cardiac arrhythmias research .
Cat. No.: HY-106593
CAS No.: 40574-52-5
Synonyms: SC 23133
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Prorenone (SC 23133) is a spironolactone-type steroidal mineralocorticoid receptor (MR) antagonist that can cross the blood-brain barrier, with low affinity for glucocorticoid receptors and rat prostate androgen receptors. Prorenone inhibits the binding and action of Aldosterone (HY-113313), blocks its induced nuclear receptor activity and stimulated sodium transport, antagonizes aldosterone-induced urinary potassium excretion, and prevents aldosterone-induced elevation of blood pressure. Prorenone can be used in research related to hypertension .
Cat. No.: HY-107397R
CAS No.: 110368-33-7
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Ch55 (Standard) is the analytical standard of Ch55 (HY-107397). This product is intended for research and analytical applications. Ch55 is a potent synthetic retinoid. Ch55 binds to RAR-α and RAR-β receptors with high affinity. Ch55 displays low affinity for cellular retinoic acid binding protein (CRABP). Ch55 is a potent inducer of the differentiation of HL60 cells with an EC50 of 200 nM. Ch55 can be used for cancer research .
Cat. No.: HY-16688R
CAS No.: 66611-26-5
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Research Areas:
RU 24969 (Standard) is the analytical standard of RU 24969. This product is intended for research and analytical applications. RU 24969 is a preferential 5-HT1B agonist, with a Ki of 0.38 nM, but also displays appreciable affinity for the 5-HT1A receptor (Ki=2.5 nM), and has low affinity for other receptor sites in the brain. RU 24969 could decrease fluid consumption and increase forward locomotion .
Cat. No.: HY-P7271
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: NGFR; low affinity Neurotrophin Receptor P75NTR; Nerve Growth Factor Receptor; TNFR Superfamily, Member 16; TNFRSF16; NGF Receptor; P75NTR; Gp80-LNGFR; CD271; P75 ICD; Tumor Necrosis Factor Receptor Superfamily Member 16; Nerve Growth Factor Receptor (TNF
Species:
Human
Source:
HEK293
Cat. No.: HY-P73318
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: NGFR; low affinity Neurotrophin Receptor P75NTR; Nerve Growth Factor Receptor; TNFR Superfamily, Member 16; TNFRSF16; NGF Receptor; P75NTR; Gp80-LNGFR; CD271; P75 ICD; Tumor Necrosis Factor Receptor Superfamily Member 16; Nerve Growth Factor Receptor (TNF
Species:
Human
Source:
HEK293
Cat. No.: HY-P74699
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: NGFR; low affinity Neurotrophin Receptor P75NTR; Nerve Growth Factor Receptor; TNFR Superfamily, Member 16; TNFRSF16; NGF Receptor; P75NTR; Gp80-LNGFR; CD271; P75 ICD; Tumor Necrosis Factor Receptor Superfamily Member 16; Nerve Growth Factor Receptor (TNF
Species:
Rabbit
Source:
HEK293
Cat. No.: HY-P74700
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: NGFR; low affinity Neurotrophin Receptor P75NTR; Nerve Growth Factor Receptor; TNFR Superfamily, Member 16; TNFRSF16; NGF Receptor; P75NTR; Gp80-LNGFR; CD271; P75 ICD; Tumor Necrosis Factor Receptor Superfamily Member 16; Nerve Growth Factor Receptor (TNF
Species:
Rabbit
Source:
HEK293
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
