5 Results for "

(1R,9S)-

" in MedChemExpress (MCE) Product Catalog:
Products (5)

5 Results for "(1R,9S)-" in MCE Product Catalog:

Cat. No.: HY-B0927
CAS No.: 118-08-1
Synonyms: (-)-β-Hydrastine; (1R,9S)-β-Hydrastine
Hydrastine ((-)-β-Hydrastine; (1R,9S)-β-Hydrastine) is a selective competitive inhibitor of tyrosine hydroxylase (TH), inhibiting dopamine biosynthesis (IC50=20.7 μM, PC12 cells). Hydrastine also inhibits the organic cation transporter OCT1 (IC50=6.6 μM). Hydrastine may cause neuronal toxicity through mitochondrial dysfunction rather than oxidative stress damage, and can aggravate cell apoptosis when combined with L-DOPA. Hydrastine can be used to study Parkinson's disease-related dopaminergic neuronal damage .
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Cat. No.: HY-13631T
CAS No.: 2231666-57-0
Synonyms: (1R,9S)-DX-8951
Research Areas:  

Cancer

(1R,9S)-Exatecan (DX8951) is the (1R,9S) stereoisomer of Exatecan (HY-13631). Exatecan (DX-8951) is a DNA topoisomerase I inhibitor, with an IC50 of 2.2 μM (0.975 μg/mL), and can be used in cancer research .
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Cat. No.: HY-13631K
CAS No.: 2766786-58-5
Target:  

ADC Payloads

Research Areas:  

Cancer

(1R,9S)-Dxd is an isomer of (Dxd) HY-13631D. (1R,9S)-Dxd is an ADC payload that can be used in the synthesis of ADCs (antibody-drug conjugates) .
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Cat. No.: HY-13631N
CAS No.: 2489613-17-2
Synonyms: (9R)-DX8951f
Research Areas:  

Cancer

(9R)-Exatecan (DX8951f) is the (1R,9S) stereoisomer of Exatecan (HY-13631). Exatecan (DX-8951) is a DNA topoisomerase I inhibitor, with an IC50 of 2.2 μM (0.975 μg/mL), and can be used in cancer research.
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Cat. No.: HY-B0927R
CAS No.: 118-08-1
Synonyms: (-)-β-Hydrastine (Standard); (1R,9S)-β-Hydrastine (Standard)
Hydrastine (Standard) is the analytical standard of Hydrastine (HY-B0927). This product is intended for research and analytical applications. Hydrastine ((-)-β-Hydrastine; (1R,9S)-β-Hydrastine) is a selective competitive inhibitor of tyrosine hydroxylase (TH), inhibiting dopamine biosynthesis (IC50=20.7 μM, PC12 cells). Hydrastine also inhibits the organic cation transporter OCT1 (IC50=6.6 μM). Hydrastine may cause neuronal toxicity through mitochondrial dysfunction rather than oxidative stress damage, and can aggravate cell apoptosis when combined with L-DOPA. Hydrastine can be used to study Parkinson's disease-related dopaminergic neuronal damage .
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