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Results for "

α-Amylase inhibitory

" in MedChemExpress (MCE) Product Catalog:

標的別:	Amylases (13) Angiotensin-converting Enzyme (ACE) (1) Apoptosis (1) Bcl-2 Family (1) Caspase (1) Cholinesterase (ChE) (1) COX (1) Dipeptidyl Peptidase (1) Drug Metabolite (1) GLUT (1) Glycosidase (9) Lipase (1) MDM-2/p53 (1) NF-κB (2) NO Synthase (1) NOD-like Receptor (NLR) (1) P-glycoprotein (1) P2Y Receptor (1) p38 MAPK (1) Parasite (1) PARP (1) PPAR (1) Pyroptosis (1) Reactive Oxygen Species (ROS) (1) SARS-CoV (1) TNF Receptor (1)
研究分野別:	Cancer (3) Endocrinology (1) Infection (2) Inflammation/Immunology (7) Metabolic Disease (14)

標的別:

Amylases (13)

Angiotensin-converting Enzyme (ACE) (1)

Apoptosis (1)

Bcl-2 Family (1)

Caspase (1)

Cholinesterase (ChE) (1)

COX (1)

Dipeptidyl Peptidase (1)

Drug Metabolite (1)

GLUT (1)

Glycosidase (9)

Lipase (1)

MDM-2/p53 (1)

NF-κB (2)

NO Synthase (1)

NOD-like Receptor (NLR) (1)

P-glycoprotein (1)

P2Y Receptor (1)

p38 MAPK (1)

Parasite (1)

PARP (1)

PPAR (1)

Pyroptosis (1)

Reactive Oxygen Species (ROS) (1)

SARS-CoV (1)

TNF Receptor (1)

研究分野別:

Cancer (3)

Endocrinology (1)

Infection (2)

Inflammation/Immunology (7)

Metabolic Disease (14)

阻害剤およびアゴニスト

生化学アッセイ試薬

天然物

Targets Recommended: Macrophage migration inhibitory factor (MIF)

製品番号	製品名	Target	研究分野	構造式

HY-113159

Docosapentaenoic acid (22n-3) Clupanodonic acid	Amylases Glycosidase	Metabolic Disease Inflammation/Immunology
Docosapentaenoic acid (22n-3) is a component of phospholipids. Docosapentaenoic acid 22n-3 has inhibitory activity against *α-amylase* and α-glucosidase, with IC₅₀s value of 17 μg/mL and 22 μg/mL, respectively. Docosapentaenoic acid 22n-3 increases cell vitality. Docosapentaenoic acid 22n-3 has a weak anti-inflammatory effect .

HY-N8599

Cichoriin 2 Publications Verification	Amylases Glycosidase Lipase Dipeptidyl Peptidase p38 MAPK PPAR P2Y Receptor NOD-like Receptor (NLR) SARS-CoV Pyroptosis GLUT Angiotensin-converting Enzyme (ACE) NF-κB	Infection Metabolic Disease Inflammation/Immunology
Cichoriin is an orally active coumarin glycoside with broad biological activities. Cichoriin exhibits inhibitory activities against *α-amylase, α-glucosidase, pancreatic lipase* and DPP-IV, with IC₅₀ values of 5.76, 2.94, 16.83 and 9.16 μg/mL, respectively. Cichoriin significantly improves metabolic dysfunction-associated steatohepatitis (MASH) in mice by activating the AMPK signaling pathway. Cichoriin upregulates PPAR-γ in adipose tissue and alleviates obesity and associated cardiorenal injury in rats. Cichoriin blocks monosodium urate crystal-induced activation of the NLRP3 inflammasome and cell pyroptosis by inhibiting P2Y₁₄R (IC₅₀ = 8.47 nM). In silico virtual screening reveals that Cichoriin has a strong binding affinity for SARS-CoV-2 .

HY-N1731

2′-Hydroxy-5′-methoxyacetophenone	NF-κB COX TNF Receptor NO Synthase Reactive Oxygen Species (ROS) Parasite	Infection Metabolic Disease Inflammation/Immunology Cancer
2'-Hydroxy-5'-methoxyacetophenone is an acetophenone derivative with acaricidal activities. 2'-Hydroxy-5'-methoxyacetophenone attenuates the inﬂammatory response via NF-κB signaling pathway. 2'-Hydroxy-5'-methoxyacetophenone exhibits significant inhibitory activity against α-amylase, collagenase and aldose reductase (AR) with IC₅₀s of 0.928, 3.264 and 20.046 μM, highlighting its potential in combating diabetes. 2'-Hydroxy-5'-methoxyacetophenone exhibits anti-ovarian cancer activity .

HY-N12999

Stigmast-5-en-3-ol	Apoptosis Bcl-2 Family Caspase MDM-2/p53 PARP Amylases	Metabolic Disease Endocrinology Cancer
Stigmast-5-en-3-ol induces cancer cell apoptosis and inhibits proliferation by increasing the production of Bax, Caspase-9, p53, and PARP cleavage and reducing Bcl-xl expression. Stigmast-5-en-3-ol exhibits potent inhibitory activity against glucoamylase and *α-amylase* and possesses high antioxidant activity. Stigmast-5-en-3-ol can be used in the research of diseases such as leukemia, breast cancer, type 2 diabetes, and obesity .

HY-179511

α-Glucosidase-IN-104	Glycosidase	Metabolic Disease
α-Glucosidase-IN-104 (Compound 9s) is an efficient inhibitor of α-glucosidase with an IC₅₀ of 24.32 μM. α-Glucosidase-IN-104 has a weak inhibitory effect on α-amylase and avoids gastrointestinal side effects. α-Glucosidase-IN-104 can be used for research on type 2 diabetes .

HY-149008

α-Amylase-IN-3	Amylases Cholinesterase (ChE)	Inflammation/Immunology
α-Amylase-IN-3 (Compound 4) is the inhibitor for *α-Amylase, AChE* and AChE with IC₅₀s of 18.04 μM, 21.04 μM and 22.2 μM, respectively. α-Amylase-IN-3 exhibits antioxidant activity. α-Amylase-IN-3 can be used in research of diabetes and oxidative stress associated disease .

HY-149313

α‑Amylase-IN-1	Amylases	Metabolic Disease
α Amylase-IN-1 (Compound 11) is an *α-Amylase* inhibitor with an IC₅₀ value of 0.5509 μM. α Amylase-IN-1 has antioxidant activity with an IC₅₀ value of 53.49 μM for scavenging DPPH free radicals. IC₅₀ can be used in the study of diabetes and oxidative stress-related diseases.

HY-N12263

3,5,6,7,8,4'-Hexamethoxyflavone	Amylases	Metabolic Disease
3,5,6,7,8,4'-Hexamethoxyflavone is a inhibitor of *α-Amylase* with the inhibitory activity of 28.3% at 500 μM .

HY-172211

α-Amylase/α-Glucosidase-IN-17	Amylases Glycosidase	Metabolic Disease Cancer
α-Amylase/α-Glucosidase-IN-17 (Compound 3) is an inhibitor of *α-amylase* and α-glucosidase, with IC₅₀ values of 14.61 μM and 25.38 μM, respectively. α-Amylase/α-Glucosidase-IN-17 has certain inhibitory activity against A549 cancer cells. α-Amylase/α-Glucosidase-IN-17 has anti-tumor and anti-diabetic effects .

HY-170796

α-Amylase-IN-11	Amylases	Metabolic Disease
α-Amylase-IN-11 (compound C5f) is an *α-Amylase* inhibitor (IC₅₀=0.56 μM) that can reduce the sugar level in vivo. α-Amylase-IN-11 has a moderate inhibitory effect on α-glucosidase (α-glucosidase), with IC₅₀=11.03 μM. α-Amylase-IN-11 can significantly reduce the glucose concentration in a mouse model and has the potential for use in diabetes research .

HY-162373

α-Amylase/α-Glucosidase-IN-10	Amylases Glycosidase P-glycoprotein	Metabolic Disease
α-Amylase/α-Glucosidase-IN-10 (compound 5d) is an α-amylase and α-glucosidase inhibitor (IC₅₀: 30.39 μM and 65.1 μM) with potential diabetes inhibitory effects. α-Amylase/α-Glucosidase-IN-10 exhibits high gastrointestinal (GI) absorption in ADMET (Absorption, Distribution, Metabolism, Excretion and Toxicity) prediction. While α-Amylase/α-Glucosidase-IN-10 acts as a substrate for P-gp and does not cross the blood-brain barrier (BBB), there may be a risk of central nervous system side effects .

HY-N16656

Ladyginoside A	Amylases Glycosidase	Metabolic Disease Inflammation/Immunology
Ladyginoside A is a triterpenoid saponin found in the leaves of Polyscias fruticosa (L.) Harms. Ladyginoside A has inhibitory activities against *α-amylase* and α-glucosidase, and can regulate carbohydrate metabolism. Ladyginoside A also exhibits potential anti-inflammatory and mast cell stabilizing effects. Ladyginoside A can be used for the researches of inflammation and metabolic disease, such as diabetes .

HY-113159A

Docosapentaenoic acid (22n-3) sodium Clupanodonic acid sodium	Amylases Glycosidase	Metabolic Disease Inflammation/Immunology
Docosapentaenoic acid (22n-3) sodium is a component of phospholipids. Docosapentaenoic acid 22n-3 sodium has inhibitory activity against *α-amylase* and α-glucosidase, with IC₅₀s value of 17 μg/mL and 22 μg/mL, respectively. Docosapentaenoic acid 22n-3 sodium increases cell vitality. Docosapentaenoic acid 22n-3 sodium has a weak anti-inflammatory effect .

HY-179698

α-Glucosidase-IN-105	Glycosidase Amylases	Metabolic Disease
α-Glucosidase-IN-105 is a selective and potent α-Glucosidase inhibitor with an IC₅₀ of 31.36 μM. α-Glucosidase-IN-105 also inhibits *α-Amylase* (IC₅₀ = 104.2 μM). α-Glucosidase-IN-105 exhibits inhibitory effects comparable to the standard drug \rAcarbose (HY-B0089). α-Glucosidase-IN-105 can be used for the research of type 2 diabetes .

HY-172832

(±)7(8)-DiHDTE	Drug Metabolite Amylases Glycosidase	Metabolic Disease Inflammation/Immunology
(±)7(8)-DiHDTE is a metabolite of Docosapentaenoic acid (22n-3) (HY-113159). Docosapentaenoic acid (22n-3) is a component of phospholipids. Docosapentaenoic acid 22n-3 has inhibitory activity against *α-amylase* and α-glucosidase with IC₅₀s of 17 and 22 μg/mL, respectively. Docosapentaenoic acid 22n-3 increases cell vitality. Docosapentaenoic acid 22n-3 has a weak anti-inflammatory effect .

製品番号	製品名	Type

HY-N1731

2′-Hydroxy-5′-methoxyacetophenone	生化学アッセイ試薬
2'-Hydroxy-5'-methoxyacetophenone is an acetophenone derivative with acaricidal activities. 2'-Hydroxy-5'-methoxyacetophenone attenuates the inﬂammatory response via NF-κB signaling pathway. 2'-Hydroxy-5'-methoxyacetophenone exhibits significant inhibitory activity against α-amylase, collagenase and aldose reductase (AR) with IC₅₀s of 0.928, 3.264 and 20.046 μM, highlighting its potential in combating diabetes. 2'-Hydroxy-5'-methoxyacetophenone exhibits anti-ovarian cancer activity .

2′-Hydroxy-5′-methoxyacetophenone

生化学アッセイ試薬

2'-Hydroxy-5'-methoxyacetophenone is an acetophenone derivative with acaricidal activities. 2'-Hydroxy-5'-methoxyacetophenone attenuates the inﬂammatory response via NF-κB signaling pathway. 2'-Hydroxy-5'-methoxyacetophenone exhibits significant inhibitory activity against α-amylase, collagenase and aldose reductase (AR) with IC₅₀s of 0.928, 3.264 and 20.046 μM, highlighting its potential in combating diabetes. 2'-Hydroxy-5'-methoxyacetophenone exhibits anti-ovarian cancer activity .

Docosapentaenoic acid (22n-3) Clupanodonic acid	Structural Classification Human Gut Microbiota Metabolites Classification of Application Fields Ketones, Aldehydes, Acids Disease markers Endocrine diseases Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Amylases Glycosidase
Docosapentaenoic acid (22n-3) is a component of phospholipids. Docosapentaenoic acid 22n-3 has inhibitory activity against *α-amylase* and α-glucosidase, with IC₅₀s value of 17 μg/mL and 22 μg/mL, respectively. Docosapentaenoic acid 22n-3 increases cell vitality. Docosapentaenoic acid 22n-3 has a weak anti-inflammatory effect .

Cichoriin 2 Publications Verification	Infection Structural Classification Monophenols other families Classification of Application Fields Coumarins Phenols Phenylpropanoids Plants Disease Research Fields Source Classification	Amylases Glycosidase Lipase Dipeptidyl Peptidase p38 MAPK PPAR P2Y Receptor NOD-like Receptor (NLR) SARS-CoV Pyroptosis GLUT Angiotensin-converting Enzyme (ACE) NF-κB
Cichoriin is an orally active coumarin glycoside with broad biological activities. Cichoriin exhibits inhibitory activities against *α-amylase, α-glucosidase, pancreatic lipase* and DPP-IV, with IC₅₀ values of 5.76, 2.94, 16.83 and 9.16 μg/mL, respectively. Cichoriin significantly improves metabolic dysfunction-associated steatohepatitis (MASH) in mice by activating the AMPK signaling pathway. Cichoriin upregulates PPAR-γ in adipose tissue and alleviates obesity and associated cardiorenal injury in rats. Cichoriin blocks monosodium urate crystal-induced activation of the NLRP3 inflammasome and cell pyroptosis by inhibiting P2Y₁₄R (IC₅₀ = 8.47 nM). In silico virtual screening reveals that Cichoriin has a strong binding affinity for SARS-CoV-2 .

Stigmast-5-en-3-ol	Cardiacglycosides Scrophulariaceae Scrophularia takesimensis Plants Lipid Steroids Source Classification	Apoptosis Bcl-2 Family Caspase MDM-2/p53 PARP Amylases
Stigmast-5-en-3-ol induces cancer cell apoptosis and inhibits proliferation by increasing the production of Bax, Caspase-9, p53, and PARP cleavage and reducing Bcl-xl expression. Stigmast-5-en-3-ol exhibits potent inhibitory activity against glucoamylase and *α-amylase* and possesses high antioxidant activity. Stigmast-5-en-3-ol can be used in the research of diseases such as leukemia, breast cancer, type 2 diabetes, and obesity .

3,5,6,7,8,4'-Hexamethoxyflavone	Flavonoids Flavones Varthemia iphionoides Boiss Plants Compositae Source Classification	Amylases
3,5,6,7,8,4'-Hexamethoxyflavone is a inhibitor of *α-Amylase* with the inhibitory activity of 28.3% at 500 μM .

Ladyginoside A	Triterpenes Structural Classification Terpenoids Polyscias fruticosa (L.) Harms Plants Araliaceae Source Classification	Amylases Glycosidase
Ladyginoside A is a triterpenoid saponin found in the leaves of Polyscias fruticosa (L.) Harms. Ladyginoside A has inhibitory activities against *α-amylase* and α-glucosidase, and can regulate carbohydrate metabolism. Ladyginoside A also exhibits potential anti-inflammatory and mast cell stabilizing effects. Ladyginoside A can be used for the researches of inflammation and metabolic disease, such as diabetes .

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