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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
56 Results for "
π-π
" in MedChemExpress (MCE) Product Catalog:
Products (56)
56 Results for "π-π" in MCE Product Catalog:
1
1 Cited Publications
Cat. No.: HY-D0823
CAS No.: 146368-16-3
Synonyms: Sulfo-Cy3 NHS ester; Sulfo Cyanine3 NHS ester
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1 Cited Publications
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IDO1/TDO-IN-4 is a potent IDO1/TDO dual inhibitor, with IC50 values of 3.53 μM (IDO1) and 1.15 μM (TDO). IDO1/TDO-IN-4 forms hydrogen bond with IDO1, and π−π stacking interaction with TDO. IDO1/TDO-IN-4 can be used in the research of depression, and depression-induced infectious, metabolic, and autoimmune disorders .
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1 Cited Publications
Cat. No.: HY-K1080
MCE Annexin V-iFluor 488/PI Apoptosis Detection Kit provides a rapid and convenient method to detect cell apoptosis and necrosis. After staining, live cells show little or no fluorescence (Annexin V-/PI-),, early apoptosis cells show green fluorescence (Annexin V+/PI-), late apoptosis cells and necrosis cells show red and green fluorescence (Annexin V+/PI+).
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Isoindigo acts as the acceptor unit in donor-acceptor (D-A) conjugated polymers and belongs to the indigo dye family. Isoindigo contains two lactam rings and exhibits strong electron-withdrawing properties. Isoindigo can be used in dyeing and pigment preparation. Isoindigo shows high mobility and excellent environmental stability in field-effect transistors (FETs). Isoindigo possesses the activity to inhibit tumor cell proliferation and has certain anti-tumor activity .
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Ketones, Aldehydes, Acids Other Diseases Phenols Polyphenols Endogenous metabolite Disease Research Fields
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Cat. No.: HY-177063
CAS No.: 296790-70-0
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IL-6-IN-2 is an interleukin-6 (IL-6) inhibitor. IL-6-IN-2 binds to IL-6 at Lys66, Phe74, Gln175, Ser176, and Arg179 via π-π, π-alkyl, hydrogen bond, and hydrophobic interactions to block IL-6/IL-6R heterocomplex formation. IL-6-IN-2 exhibits low gastrointestinal absorption rate. IL-6-IN-2 can be used for the research of cytokine release syndrome, covid-19 .
Cat. No.: HY-W196368
CAS No.: 2217-60-9
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Cat. No.: HY-W012911
CAS No.: 1513-65-1
Cat. No.: HY-W009641
CAS No.: 24463-15-8
Synonyms: PyM; 1-HMP
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1-Pyrenemethanol is an organic compound that can be used to prepare graphene films with excellent thermal conductivity, flexibility and mechanical properties. 1-Pyrenemethanol binds to graphene oxide sheets through hydrogen bonds and π-π interactions to form GO-PyM films, increasing the dispersion and stability of the material .
Cat. No.: HY-149827
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MTHFD2-IN-3 is a selective inhibitor of MTHFD2. MTHFD2-IN-3 binds to the substrate-binding site of MTHFD2, forms hydrogen bonds with Arg43, Lys88, Gln132, Asn87 and Gly310, and undergoes π-π stacking with Tyr84. MTHFD2-IN-3 can be used in cancer-related research .
Cat. No.: HY-149826
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MTHFD2-IN-2 is a selective MTHFD2 inhibitor with poor binding to MTHFD1. MTHFD2-IN-2 binds to the MTHFD2 substrate binding site, forming π-π stacking with Tyr84, hydrogen bond/salt-bridge contacts with Arg43 and Asn87, and lipophilic interactions with Ile276. MTHFD2-IN-2 exhibits predicted anticancer activity. MTHFD2-IN-2 can be used for the research of cancer .
Cat. No.: HY-179041
CAS No.: 924851-91-2
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PGE synthase Prostaglandin Receptor MDM-2/p53 Amino acid Transporter Glutathione Peroxidase Ferroptosis
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SZ0232 is a selective mPGES-2 inhibitor. SZ0232 binds to the active site of mPGES-2 via hydrogen bonds and π-π stacking, reduces the production of prostaglandin E2 (PGE2) and blocks the PGE2-EP3 pathway. SZ0232 regulates Ferroptosis by activating the heme-dependent p53/SLC7A11/GPX4 axis, inhibits lipid peroxidation, and protects renal tubules. SZ0232 enhances glucose-stimulated insulin secretion, inhibits β-cell senescence, and improves glucose homeostasis. SZ0232 reduces renal lipid accumulation, alleviates fibrosis, and ameliorates renal dysfunction in diabetic mice. SZ0232 inhibits renal cyst growth in polycystic kidney disease models. SZ0232 exhibits an insulinotropic effect that strengthens with the increase of animal age. SZ0232 can be used in studies related to type 2 diabetes, acute kidney injury, diabetic kidney disease, and autosomal dominant polycystic kidney disease .
Cat. No.: HY-32927
CAS No.: 150255-96-2
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3-Cyanophenylboronic acid is an arylboronic acid-based boronic acid reagent that serves as a coupling partner in Suzuki-Miyaura cross-coupling reactions. 3-Cyanophenylboronic acid participates in reactions to synthesize 4'-propoxybiphenyl-3-carbonitrile .
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Phytoene desaturase-IN-1 is a potent phytoene desaturase (PDS) inhibitor (Kd: 65.9 μM) through π−π stacking effect with Phe301 residue. Phytoene desaturase-IN-1 shows broad spectrum of postemergence herbicidal activity. Phytoene desaturase-IN-1 induces PDS mRNA reduction, phytoene and reactive oxygen species (ROS) accumulation in albino leaves. Phytoene desaturase-IN-1 can be used in the area of agricultural production .
Cat. No.: HY-33821
CAS No.: 171049-41-5
LXRβ ligand 1 is a LXR β ligand-binding domain agonist, with an EC50 of 57 μM and a Ki of 28 μM against human LXR β. LXRβ ligand 1 forms hydrogen bonds with His435, stabilizes the His-Trp activation switch, and locks the ligand-binding domain in an agonist conformation; its tert-butyl moiety occupies a hydrophobic subpocket, while its phenyl moiety forms a π-π stacking interaction with Phe329. LXRβ ligand 1 serves as a structural unit for the development of LXRβ modulators .
Cat. No.: HY-146081
CAS No.: 2493080-27-4
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CD22 ligand-1 is a CD22-selective ligand with a Kd value of 0.335 μM for human CD22. CD22 ligand-1 binds to CD22 with high affinity and can be used for drug conjugation to achieve B cell targeting or multimer formation. CD22 ligand-1 is applicable to the study of B cell-mediated autoimmune diseases and B cell-associated lymphomas .
Cat. No.: HY-169228
CAS No.: 2759280-09-4
WS-11 is a non-covalent reversible BTK inhibitor with IC50s of 3.9 nM and 2.2 nM for wild type, C481S mutation BTK, respectively. WS-11 can form strong π-π interaction with PHE540 and form p-π interaction with LYS430 within the active pocket, besides the strong hydrogen bonds .
Cat. No.: HY-178923
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NNRT-IN-14 is an HIV-1 reverse transcriptase inhibitor (IC50 = 0.175 µM). NNRT-IN-14 can form hydrogen bonds with LYS101, PRO225, and PHE227, and π–π stacking with TYR181 and TRP229. NNRT-IN-14 can be used for the study of HIV .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
