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12-O-Tiglyl-phorbol 13-dodecanoate

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12-O-Tiglyl-phorbol 13-dodecanoate
12-O-Tiglyl-phorbol 13-dodecanoate
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Cat. No.: HY-N11736
CAS No.: 37394-32-4
Category:  

Euphorbia fischeriana Steud. Natural Products Plants Euphorbiaceae Extract

Target:  

Collagen

12-O-Tiglyl-phorbol 13-dodecanoate (TD13) is a potential inhibitor with anti-hepatic fibrosis activity, and it belongs to a series of derivatives of oral APOL2 inhibitors and anti-hepatic fibrosis agents. It shows no obvious toxicity in preclinical models. Compounds of the 12-O-Tiglyl-phorbol 13-dodecanoate series inhibit the expression of fibronectin, type I collagen and α-smooth muscle actin in hepatic stellate cells. 12-O-Tiglyl-phorbol 13-dodecanoate can be isolated from the Euphorbiaceae plant Euphorbia fischeriana, and it is applicable to the research of hepatic fibrosis .
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