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5 Results for "
3-Hydroxy Midostaurin
" in MedChemExpress (MCE) Product Catalog:
Products (5)
5 Results for "3-Hydroxy Midostaurin" in MCE Product Catalog:
Synonyms: CGP52421
3-Hydroxy Midostaurin (CGP 52421), a metabolite of PKC412, effectively inhibits FMS-like tyrosine kinase-3 (FLT3) autophosphorylation with IC50s of approximately 132 nM and 9.8 μM in culture medium and plasma, respectively. 3-Hydroxy Midostaurin is less selective but more cytotoxic than PKC412 .
Cat. No.: HY-108263B
CAS No.: 155848-20-7
Synonyms: (R)-CGP52421
Target:
Research Areas:
(R)-3-Hydroxy Midostaurin ((R)-CGP52421) is a potent kinases inhibitor. (R)-3-Hydroxy Midostaurin is a major metabolite of midostaurin (PKC412; HY-10230) undergoing by the hepatic CYP3A4 enzyme. (R)-3-Hydroxy Midostaurin has the potential for acute myeloid leukemia (AML) .
Cat. No.: HY-108263S
Synonyms: CGP52421-d5
Cat. No.: HY-W751180
Synonyms: CGP52421-13C6
Cat. No.: HY-108263A
CAS No.: 945260-14-0
Synonyms: (S)-CGP52421
Target:
Research Areas:
(S)-3-Hydroxy Midostaurin ((S)-CGP52421) is a potent kinases inhibitor with IC50 values of <400 nM for 13 kinases (VEGFR-2, TRK-A, FLT3, et). (S)-3-Hydroxy Midostaurin is a minor metabolite of midostaurin (PKC412; HY-10230) undergoing by the hepatic CYP3A4 enzyme. (S)-3-Hydroxy Midostaurin has the potential for acute myeloid leukemia (AML) .
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