50 Results for "

A/TianjinJinnan /15/2009

" in MedChemExpress (MCE) Product Catalog:
Products (50)

50 Results for "A/TianjinJinnan /15/2009" in MCE Product Catalog:

65
65 Publications Verification
Cat. No.: HY-101120
CAS No.: 1433286-70-4
Purity:  99.74%
Research Areas:  

Cancer

666-15 is a potent and selective CREB inhibitor with an IC50 of 81 nM. 666-15 suppresses tumor growth in a breast cancer xenograft model .
loading...
    loading...
43
43 Cited Publications
Cat. No.: HY-103449
CAS No.: 1161002-05-6
Purity:  ≥99.0%
Target:  

Estrogen Receptor/ERR

Research Areas:  

Cancer

G15 is a high affinity and selective G-protein-coupled estrogen receptor (GPER/GPR30) antagonist with a Ki of 20 nM .
loading...
    loading...
33
33 Cited Publications
Cat. No.: HY-100437
CAS No.: 1609402-14-3
Purity:  99.98%
Target:  

HSP Autophagy Apoptosis

Research Areas:  

Cancer

HA15 is a potent and specific inhibitor of ER chaperone BiP/GRP78/HSPA5, inhibits the ATPase activity of BiP, with anti-cancerous activity .
loading...
    loading...
3
3 Cited Publications
Cat. No.: HY-100828
CAS No.: 66611-37-8
Purity:  ≥98.0%
Target:  

PARP

Research Areas:  

Cardiovascular Disease Cancer

BGP-15 is a PARP inhibitor, with an IC50 and a Ki of 120 and 57 μM, respectively.
loading...
    loading...
2
2 Cited Publications
Cat. No.: HY-100441
CAS No.: 81846-19-7
Purity:  99.95%
Synonyms: UT-15
Treprostinil (UT-15) is a potent DP1 and EP2 agonist with EC50 values of 0.6±0.1 and 6.2±1.2 nM, respectively.
loading...
    loading...
Cat. No.: HY-100441S2
CAS No.: 2747918-14-3
Purity:  99.79%
Synonyms: UT-15-d9
Research Areas:  

Inflammation/Immunology

Treprostinil-d9 (UT-15-d9) is the deuterium-labeled Treprostinil (HY-100441) . Treprostinil (UT-15) is a potent DP1 and EP2 agonist with EC50 values of 0.6±0.1 and 6.2±1.2 nM, respectively.
loading...
    loading...
Cat. No.: HY-100807S2
Quinolinic acid-13C4, 15N is an isotopic labeled Quinolinic acid (HY-100807). Quinolinic acid, an endogenous metabolite of tryptophan, is a N-methyl-D-aspartate receptor (NMDA receptor) agonist. Quinolinic acid increases glutamate efflux, induces the generation of ROS, activates nitric oxide synthase, produces excessive NO, leading to calcium ion influx and neuronal apoptosis.
loading...
    loading...
Cat. No.: HY-102049
CAS No.: 1831830-20-6
Purity:  99.79%
Target:  

Interleukin Related

Research Areas:  

Inflammation/Immunology

IL-15-IN-1 (compound 76) is a potent and selective Interleukin 15 (IL-15) inhibitor, inhibiting the proliferation of IL-15-dependent cells with an IC50 of 0.8 μM .
loading...
    loading...
Cat. No.: HY-103476
CAS No.: 91917-65-6
Purity:  99.17%
Target:  

GABA Receptor

Research Areas:  

Neurological Disease

Ro15-4513, imidazobenzodiazepinone derivative, is a partial inverse agonist of benzodiazepine receptor (BZR) . Ro15-4513 is a potent ethanol antagonist . Ro15-4513 has anti-anxiety effect . Ro15-4513 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
loading...
    loading...
Cat. No.: HY-101064S1
CAS No.: 1163133-36-5
Fmoc-leucine- 13C6, 15N is a 15N-labeled and 13C-labled Fmoc-leucine. Fmoc-leucine is a selective PPARγ modulator. Fmoc-leucine activates PPARγ with a lower potency but a similar maximal efficacy than rosiglitazone. Fmoc-leucine improves insulin sensitivity
loading...
    loading...
Cat. No.: HY-10585S2
CAS No.: 362049-65-8
Purity:  ≥99.0%
Synonyms: VPA-d15; 2-Propylpentanoic acid-d15
Valproic acid-d15 is the deuterium labeled Valproic acid. Valproic acid (VPA; 2-Propylpentanoic Acid) is an HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid sodium salt is used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches .
loading...
    loading...
Cat. No.: HY-101037S
Purity:  ≥99.0%
Synonyms: N-Methylglycine-15N; Sarcosin-15N
Sarcosine- 15N is the 15N-labeled Sarcosine. Sarcosine (N-Methylglycine), an endogenous amino acid, is a competitive glycine transporter type I (GlyT1) inhibitor and N-methyl-D-aspartate (NMDA) receptor co-agonist. Sarcosine increases the glycine concentration, resulting in an indirect potentiation of the NMDA receptor. Sarcosine is commonly used for the research of schizophrenia .
loading...
    loading...
Cat. No.: HY-104031
CAS No.: 220757-88-0
Purity:  99.37%
Target:  

Notch

Research Areas:  

Neurological Disease

tCFA15 is a trimethyl cyclohexenonic long chain fatty alcohol containing 15 carbon atoms on the side chain, promotes the differentiation of neurons, and may regulates Notch signaling.
loading...
    loading...
Cat. No.: HY-100561S
CAS No.: 90429-66-6
Synonyms: 4-Hydroxy-TEMPO-d17,15N
Tempol-d17, 15N is the deuterium labeled Tempol . Tempol is a general superoxide dismutase (SOD)-mimetic agent that efficiently neutralizes reactive oxygen species (ROS) .
loading...
    loading...
Cat. No.: HY-101399SA
Synonyms: H-γ-Glu-Phe-OH-13C9,15N TFA; γ-Glutamylphenylalanine-13C9,15N TFA
γ-Glu-(Phe-13C9,15N) (γ-Glutamylphenylalanine-13C9,15N) TFA is the 13C- and 15N-labeled γ-Glu-Phe TFA (HY-101399A). γ-Glu-Phe TFA is synthesized by Bacillus amyloliquefaciens (GBA) and Aspergillus oryzae (GAO). γ-Glu-Phe TFA or the post-enzymatic reaction mixture enhances the umami intensity of commercial soy sauce and model chicken broth .
loading...
    loading...
Cat. No.: HY-101981S
Purity:  ≥98.0%
Synonyms: 5'-Uridylic acid-15N2
Uridine 5'-monophosphate- 15N2 (5'-​Uridylic acid- 15N2) is the 15N labeled Uridine 5'-monophosphate (HY-101981). Uridine 5'-monophosphate (5'-Uridylic acid) is an orally active mitochondrial ATP-dependent potassium channel activator that has a protective effect on the heart. Uridine 5'-monophosphate can promote the synthesis of CDP-choline and induce apoptosis in intestinal epithelial cells, which is beneficial for gut development and reduces diarrhea .
loading...
    loading...
Cat. No.: HY-103327
CAS No.: 944154-76-1
Purity:  99.78%
Target:  

Cannabinoid Receptor

Research Areas:  

Metabolic Disease

MJ15 is a potent and selective CB1 receptor antagonist with a Ki of 27.2 pM and an IC50 of 118.9 pM for rat CB1 receptors. MJ15 exhibits potency in obesity and hyperlipidemia models. MJ15 inhibits food intake and increases in body weight in diet-induced obese rats and mice .
loading...
    loading...
Cat. No.: HY-103612
CAS No.: 2308035-51-8
Purity:  98.43%
Synonyms: Cereblon Ligand-Linker Conjugates 7; E3 ligase Ligand-Linker Conjugates 15
Thalidomide-O-amido-C3-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.
loading...
    loading...
Cat. No.: HY-101064S4
CAS No.: 200937-57-1
Fmoc-leucine- 15N is a 15N-labeled and 15N-labled Fmoc-leucine (HY-101064).
loading...
    loading...
Cat. No.: HY-106224AS1
Synonyms: Hypocretin-1-13C18,15N3 (human, rat, mouse) TFA
Orexin A- 13C18, 15N3 (human, rat, mouse) ((Hypocretin-1- 13C18, 15N3 (human, rat, mouse)) TFA is the 13C- and 15N-labeled Orexin A (human, rat, mouse) (HY-106224). Orexin A (human, rat, mouse) (Hypocretin-1 (human, rat, mouse)), a 33 amino acid excitatory neuropeptide, orchestrates diverse central and peripheral processes. Orexin A (human, rat, mouse) binds and activates two types of G protein-coupled receptors, the orexin-1 receptor (OX1R) and the orexin-2 receptor (OX2R). Orexin A (human, rat, mouse) has a role in the regulation of feeding behavior. Orexin A (human, rat, mouse) is an effective anti-nociceptive and anti-hyperalgesic agent in mice and rats .
loading...
    loading...