1. Stem Cell/Wnt
  2. Notch
  3. tCFA15

tCFA15 

Cat. No.: HY-104031
Handling Instructions

tCFA15 is a trimethyl cyclohexenonic long chain fatty alcohol containing 15 carbon atoms on the side chain, promotes the differentiation of neurons, and may regulates Notch signaling.

For research use only. We do not sell to patients.

tCFA15 Chemical Structure

tCFA15 Chemical Structure

CAS No. : 220757-88-0

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Top Publications Citing Use of Products
  • Biological Activity

  • Technical Information

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  • References

Description

tCFA15 is a trimethyl cyclohexenonic long chain fatty alcohol containing 15 carbon atoms on the side chain, promotes the differentiation of neurons, and may regulates Notch signaling.

IC50 & Target

Notch1[1]

In Vitro

tCFA15 (10 nM-1 μM) dose-dependently affects the differentiation of neural stem cell-derived neurospheres by promoting neurons at the expense of astrocytes, and such effect is via Notch1. tCFA15 (1 μM) specifically decreases the level of Notch1 mRNA in spheres, and such an effect is also observed in decreases Notch1 expression in neuronal and glial cell cultures[1]. tCFA15 stimulates arginine vasopressin secretion in nerve terminals of the neurohypophysis[2].

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

DMSO : 130 mg/mL (356.56 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7427 mL 13.7137 mL 27.4273 mL
5 mM 0.5485 mL 2.7427 mL 5.4855 mL
10 mM 0.2743 mL 1.3714 mL 2.7427 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.17 mg/mL (5.95 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.17 mg/mL (5.95 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Molecular Weight

364.60

Formula

C₂₄H₄₄O₂

CAS No.

220757-88-0

SMILES

O=C1C(C)=C(CCCCCCCCCCCCCCCO)C(C)(C)CC1

Shipping

Room temperature in continental US; may vary elsewhere

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
tCFA15
Cat. No.:
HY-104031
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tCFA15

Cat. No.: HY-104031