12 Results for "

ALOX12

" in MedChemExpress (MCE) Product Catalog:
Products (12)

12 Results for "ALOX12" in MCE Product Catalog:

1
1 Cited Publications
Cat. No.: HY-P72076
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: 12 LOX; 12S; lipoxygenase ; 12-lipoxygenase; 12LO; 12S LOX; 12S-lipoxygenase; 12S-LOX; 12S-type; ALOX12; Arachidonate 12 lipoxygenase; Arachidonate 12 lipoxygenase, 12S type; Arachidonate 12-lipoxygenase; Arachidonate 12-oxidoreductase; Lipoxin synthase 12-LO; LOG12; LOX12_HUMAN; P-12LO; Platelet 12-LOX; Platelet type lipoxygenase 12 ; platelet-type 12-lipoxygenase; Platelet-type lipoxygenase 12
Species:  
Source:  
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Cat. No.: HY-RS00613
Research Areas:  

Others

Alox12 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Alox12 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-113509B
CAS No.: 171030-11-8
Synonyms: 15-epi-LXA4
15 (R)-Lipoxin A4 (15-epi-LXA4) is a specialized pro-resolving mediator and an acetylated derivative of COX2. 15 (R)-Lipoxin A4 is present in neurons. 15 (R)-Lipoxin A4 induces the SPM synthases ALOX12 and ALOX15, as well as the pro-resolving receptor ALX. 15 (R)-Lipoxin A4 inhibits protein kinases, including JNK1/2/3, Lyn, STAT-3 and STAT-6. 15 (R)-Lipoxin A4 enhances the release of pro-resolving mediators. 15 (R)-Lipoxin A4 alleviates the pro-inflammatory phenotype of tendon-derived stromal cells. 15 (R)-Lipoxin A4 promotes the resolution of neuroinflammation. 15 (R)-Lipoxin A4 is applicable to research related to achilles tendinitis, achilles tendon rupture and Alzheimer’s disease .
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Cat. No.: HY-N2134
CAS No.: 103654-50-8
Synonyms: Puerarin apioside
Mirificin (Puerarin apioside) is a blood-brain barrier-permeable tyrosinase inhibitor, with an IC50 value of 12.66 μM against mushroom tyrosinase. Mirificin reduces the expression of ALOX12 in cardiomyocytes and alleviates hypoxia/reoxygenation-induced apoptosis. The neuroprotective effect of Mirificin depends on the activation of VEGFR2 and HSP1A1, which reduces cerebral infarct size and improves neurological function. Mirificin can be used in the research of hyperpigmentation, acute myocardial infarction and ischemic stroke .
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Cat. No.: HY-RS00612
Research Areas:  

Others

ALOX12 Human Pre-designed siRNA Set A contains three designed siRNAs for ALOX12 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-RS00614
Research Areas:  

Others

Alox12 Rat Pre-designed siRNA Set A contains three designed siRNAs for Alox12 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-150191
CAS No.: 2315406-63-2
Research Areas:  

Metabolic Disease

IMA-1 is an inhibitor that inhibits the interaction between arachidonic acid 12-lipoxygenase (ALOX12) and acetyl-CoA carboxylase 1 (ACC1). IMA-1 significantly blocks the progression of diet-induced non-alcoholic steatohepatitis (NASH) in male mice and crab-eating monkeys, and does not cause hyperlipidemia. IMA-1 can be used for the study of NASH .
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Cat. No.: HY-187183
IM-07 is a 12-lipoxygenase (ALOX12) ligand that can be used for the synthesis of PROTACs, such as MH-06 (HY-187182) .
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Cat. No.: HY-RS00615
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Others

ALOX12B Human Pre-designed siRNA Set A contains three designed siRNAs for ALOX12B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-187182
Research Areas:  

Inflammation/Immunology

MH-06 is an orally active 12-lipoxygenase (ALOX12) PROTAC degrader. MH-06 specifically binds to ALOX12 and recruits E3 ubiquitin ligase to mediate ubiquitination and degradation of the target protein. MH-06 inhibits the MAPK signaling pathway, reduces the production of reactive oxygen species (ROS), restores mitochondrial function, regulates macrophage polarization and decreases the release of pro-inflammatory cytokines. MH-06 can be used for the research of acute pancreatitis .
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Cat. No.: HY-P82293
Synonyms: 12 LOX; 12LO; 12S LOX; 12S-lipoxygenase; 12S-LOX; ALOX12; LOG12; P-12LO

Host:  

Rabbit

Application:  

WB

Reactivity:  

Human, Rat

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Cat. No.: HY-RS00618
Research Areas:  

Others

Alox15 Rat Pre-designed siRNA Set A contains three designed siRNAs for Alox15 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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