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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
97 Results for "
AMPK kinase
" in MedChemExpress (MCE) Product Catalog:
Products (97)
97 Results for "AMPK kinase" in MCE Product Catalog:
77
77 Publications Verification
Synonyms: MLN 8237
Target:
Research Areas:
Alisertib (MLN 8237) is an orally active and selective Aurora A kinase inhibitor (IC50=1.2 nM), which binds to Aurora A kinase resulting in mitotic spindle abnormalities, mitotic accumulation. Alisertib (MLN 8237) induces apoptosis and autophagy through targeting the AKT/mTOR/AMPK/p38 pathway in leukemic cells. Antitumor activity .
48
48 Cited Publications
Cat. No.: HY-50662
CAS No.: 844499-71-4
Target:
Research Areas:
A-769662 is a AMP-activated protein kinase (AMPK) activator. A-769662 inhibits the function of the 26S proteasome by an AMPK-independent mechanism and leads to cell cycle arrest. A-769662 directly stimulates partially purified rat liver AMPK (EC50 = 0.8 μM) and inhibits fatty acid synthesis in primary rat hepatocytes (IC50 = 3.2 μM). A-769662 can alleviate the symptoms of metabolic diseases such as type 2 diabetes .
44
44 Cited Publications
Cat. No.: HY-16966
CAS No.: 1884220-36-3
SBI-0206965 is a potent, selective and cell permeable autophagy kinase ULK1 inhibitor with IC50s of 108 nM for ULK1 kinase and 711 nM for the highly related kinase ULK2. SBI-0206965 is also an AMPK inhibitor that can paradoxically increase Thr172 phosphorylation .
42
42 Cited Publications
GSK-690693 is an ATP-competitive pan-Akt inhibitor with IC50s of 2 nM, 13 nM, 9 nM for Akt1, Akt2 and Akt3, respectively. GSK-690693 is also an AMPK inhibitor, affects Unc-51-like autophagy activating kinase 1 (ULK1) activity and robustly inhibits STING-dependent IRF3 activation .
19
19 Cited Publications
Cat. No.: HY-19330
CAS No.: 1203494-49-8
Target:
Research Areas:
DASA-58 is a potential pyruvate kinase isozyme (PKM2) allosteric activator. DASA-58 can be used for the research of metabolism and kinds of cancer .
18
18 Cited Publications
BAY-3827, a chemical probe, is a potent and selective AMPK inhibitor with IC50 values of 1.4 nM at low (10 μM ATP concentration) and 15 nM at high (2 mM ATP concentration). BAY-3827 shows over 500-fold selectivity for most of the 331 kinases. BAY-3827 prevents phosphorylation of acetyl-CoA carboxylase 1 and shows strongest anti-proliferative activity in androgen-dependent prostate cancer cell lines .
10
9
Research Areas:
Aldometanib (LXY-05-029) is an orally active aldolase inhibitor. Aldometanib can activate lysosomal adenosine monophosphate-activated protein kinase (AMPK) and decreases blood glucose. Aldometanib can be used for the research of metabolic homeostasis .
8
8 Cited Publications
Target:
Research Areas:
EX229, a Benzimidazole derivative, is a potent and allosteric activator of AMP-activated protein kinase (AMPK), with Kds of 0.06 μM, 0.06 μM and 0.51 μM for α1β1γ1, α2β1γ1 and α1β2γ1 in biolayer interferometry, respectively.
4
4 Cited Publications
Cat. No.: HY-N0772
CAS No.: 24699-16-9
4
3
3 Cited Publications
Target:
Research Areas:
MK-3903 is a potent and selective AMP-activated protein kinase (AMPK) activator with an EC50 of 8 nM.
3
3 Cited Publications
Target:
Research Areas:
Ampkinone is an indirect AMP-activated protein kinase (AMPK) activator.
3
3 Cited Publications
Cat. No.: HY-P0136
CAS No.: 125911-68-4
Target:
Research Areas:
2
2 Cited Publications
EB-3D is a potent and selective choline kinase α (ChoKα) inhibitor, with an IC50 of 1 μM for ChoKα1. EB-3D exerts effects on ChoKα expression, AMPK activation, apoptosis, endoplasmic reticulum stress and lipid metabolism. EB-3D exhibits a potent antiproliferative activity in a panel of T-leukemia cell lines. Anti-cancer activity .
2
2 Cited Publications
Target:
Research Areas:
COH-SR4 is an AMPK activator. COH-SR4 shows potent anti-proliferative activities against leukemia, melanoma, breast and lung cancers. COH-SR4 inhibits adipocyte differentiation via AMPK activation. COH-SR4 can be used for the research of obesity and related metabolic disorders .
2
2 Cited Publications
Cat. No.: HY-P80541
Synonyms: PRKAA2; AMPK; AMPK2; 5'-AMP-activated protein kinase catalytic subunit alpha-2; AMPK subunit alpha-2; Acetyl-CoA carboxylase kinase; ACACA kinase; Hydroxymethylglutaryl-CoA reductase kinase; HMGCR kinase
2
2 Cited Publications
Cat. No.: HY-P76141
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: PRKAG1; 5'-AMP-Activated Protein kinase, Gamma-1 Subunit; Protein kinase AMP-Activated Non-Catalytic Subunit Gamma 1; AMPK Subunit Gamma-1; 5'-AMP-Activated Protein kinase Subunit Gamma-1; AMPK Gamma-1 Chain; Protein kinase, AMP-Activated, Gamma 1 Non-Cat
Species:
Human
Source:
Sf9 insect cells
2
2 Cited Publications
Cat. No.: HY-P76143
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: PRKAG1; 5'-AMP-Activated Protein kinase, Gamma-1 Subunit; Protein kinase AMP-Activated Non-Catalytic Subunit Gamma 1; AMPK Subunit Gamma-1; 5'-AMP-Activated Protein kinase Subunit Gamma-1; AMPK Gamma-1 Chain; Protein kinase, AMP-Activated, Gamma 1 Non-Cat
Species:
Human
Source:
Sf9 insect cells
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
