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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
33 Results for "
Anti-osteoporosis
" in MedChemExpress (MCE) Product Catalog:
Products (33)
33 Results for "Anti-osteoporosis" in MCE Product Catalog:
9
9 Publications Verification
Cat. No.: HY-N0213
CAS No.: 18059-10-4
Synonyms: Verticinone; Raddeanine
9
9 Publications Verification
Cat. No.: HY-N0705
CAS No.: 85643-19-2
3
Category:
Cardiovascular Disease Simple Phenylpropanols Acanthopanax senticosus (Rupr. et Maxim.) Harms Phenylpropanoids Plants Disease Research Fields Araliaceae
Target:
3
3 Cited Publications
Cat. No.: HY-N1401
CAS No.: 112246-15-8
3
Category:
Flavonols Flavonoids Plants Burseraceae Disease Research Fields Inflammation/Immunology Boswellia carterii
Target:
Target:
Research Areas:
KY-02327 acetate, a metabolically stabilized KY-02061 analog, is a potent Dishevelled (Dvl)-CXXC5 interaction inhibitor. KY-02327 acetate shows an activating effect on the Wnt/β-catenin pathway, resulting in promotion of osteoblast differentiation .
Category:
Simple Phenylpropanols Acanthopanax senticosus (Rupr. et Maxim.) Harms Phenylpropanoids Plants Araliaceae
Target:
Cat. No.: HY-149472
CAS No.: 3046142-30-4
Research Areas:
Anti-osteoporosis agent-4 (Compound 11h) inhibits differentiation of primary osteoclasts. Anti-osteoporosis agent-4 attenuates RANKL-induced osteoclastogenesis. Anti-osteoporosis agent-4 inhibits osteoclast formation with an IC50 value of 358.29 nM. Anti-osteoporosis agent-4 inhibits PI3K/AKT and IκBα/NF-κB signaling pathway activation .
Cat. No.: HY-149852
CAS No.: 2944463-16-3
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Research Areas:
Anti-osteoporosis agent-3 (Compound 11), a PMSA derivative, is an anti-osteoporosis agent. Anti-osteoporosis agent-3 inhibits osteoclastogenesis with an IC50 value of 322.9 nM in vitro. Anti-osteoporosis agent-3 also blocks the formation of F-action belts and bone resorption .
Cat. No.: HY-155985
CAS No.: 445231-36-7
Target:
Research Areas:
Anti-osteoporosis agent-6 (compound 174) is an anti-osteoporosis agent. Anti-osteoporosis agent-6 has 14.11% inhibition rate against osteoclast formation at 10 μM .
Cat. No.: HY-49069
CAS No.: 445254-59-1
Target:
Research Areas:
Anti-osteoporosis agent-7 (Compound 133) is a potential anti-osteoporosis agent showing high inhibition of osteoclast formation.
Cat. No.: HY-169070
Anti-osteoporosis agent-10 is an osteoporosis inhibitor. Anti-osteoporosis agent-10 can suppress the generation of osteoclasts, with an IC50 of 0.042 μM. Anti-osteoporosis agent-10 also has antagonistic activity on PPARγ, with an EC50 value of 0.75 μM .
Cat. No.: HY-168090
CAS No.: 2869099-50-1
Target:
Research Areas:
Anti-osteoporosis agent-11 (compound 3k) is an anti-osteoporosis compound targeting osteoclasts. Anti-osteoporosis agent-11 has the most significant inhibitory effect on osteoclast differentiation, with an IC50 value of 0.36 μM. In addition, Anti-osteoporosis agent-11 inhibits osteoclast formation, bone resorption, and the expression of osteoclast-specific genes by blocking rankl-induced mitogen-activated protein kinase (MAPK) and NF-κB signaling pathways .
Cat. No.: HY-155977
CAS No.: 444908-22-9
Anti-osteoporosis agent-5 (compound 189) is a potent inhibitor of the formation of osteoclasts .
Cat. No.: HY-158311
CAS No.: 3036050-96-8
Target:
Research Areas:
Anti-osteoporosis agent-8 (Compound 4aa) is an inhibitor for RANKL, which inhibits RANKL-induced osteoclastogenesis and osteoclast differentiation (IC50 is 2.41 μM) in cells RAW264.7. Anti-osteoporosis agent-8 ameliorates bone loss in an ovariectomized (OVX) mice model .
Cat. No.: HY-145896
CAS No.: 2761577-50-6
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Anti-osteoporosis agent-1 (comp 4aa) is a potent replication protein A (RPA) inhibitor (IC50=18 µM) .
Cat. No.: HY-163847
Research Areas:
Anti-osteoporosis agent-9 (compound 5b) is a N-cyclopropyl-4-((4-((4-(trifluoromethyl)phenyl)sulfonyl)piperazin-1-yl)methyl)benzamide derivative that shows anti-osteoclast activity .
Cat. No.: HY-N10370
CAS No.: 149733-95-9
Category:
Flavonoids Flavones Morus alba L. Phenols Polyphenols Plants Moraceae Disease Research Fields Cancer
Target:
Cat. No.: HY-N11514
CAS No.: 849693-09-0
Category:
Terpenoids Bituminaria morisiana (Pignatti & Metlesics) Greuter Sesquiterpenes Plants Compositae
Target:
Cat. No.: HY-163513
CAS No.: 2515609-54-6
Target:
Research Areas:
AACA is an inhibitor for sclerostin, that binds sclerostin on loop3 region with Kd of 15.4 nM. AACA exhibits anti-osteoporosis activity through Wnt signaling pathway .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
