Anti-osteoporosis agent-4
Anti-osteoporosis agent-4 (Compound 11h) inhibits differentiation of primary osteoclasts. Anti-osteoporosis agent-4 attenuates RANKL-induced osteoclastogenesis. Anti-osteoporosis agent-4 inhibits osteoclast formation with an IC50 value of 358.29 nM. Anti-osteoporosis agent-4 inhibits PI3K/AKT and IκBα/NF-κB signaling pathway activation.
For research use only. We do not sell to patients.
- CAS No.: 3046142-30-4
- Formula: C26H26ClN3O7S
- Molecular Weight:560.02
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| BMDM | IC50 |
358.29 nM
Compound: 11h
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Anti-osteoporosis activity in mouse BMDM cells assessed as inhibition of RANKL/M-CSF-induced osteoclasts formation measured for 4 days by TRAP staining based assay
Anti-osteoporosis activity in mouse BMDM cells assessed as inhibition of RANKL/M-CSF-induced osteoclasts formation measured for 4 days by TRAP staining based assay
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[PMID: 37651877] |
Chemical Information
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CAS No. 3046142-30-4
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Molecular Weight 560.02
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Formula C26H26ClN3O7S
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SMILES
O=S(C1=CC=C(NC(C)=O)C=C1)(OC2=CC=C(NC(COC3=CC=CC=C3Cl)=O)C(N4CCOCC4)=C2)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anti-osteoporosis agent-4 Related Classifications
HY-149472 Related Classifications
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