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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
10 Results for "
Apo-IDO1 inhibitor
" in MedChemExpress (MCE) Product Catalog:
Products (10)
10 Results for "Apo-IDO1 inhibitor" in MCE Product Catalog:
2
Research Areas:
LY-3381916 (IDO1-IN-5) is a potent, selective and brain penetrated inhibitor of IDO1 activity, binds to apo-IDO1 lacking heme rather than mature heme-bound IDO1 .
1
1 Cited Publications
Synonyms: (S)-IDO1-IN-5
Research Areas:
(S)-LY-3381916 ((S)-IDO1-IN-5; Example 1B) is an active S-isomer of LY-3381916. (S)-LY-3381916 binds to IDOL with an IC50 value less than 1.5 µΜ . LY-3381916 is a potent, selective and brain penetrated inhibitor of Indoleamine 2,3-Dioxygenase 1 (IDO1) activity, binds to apo-IDO1 lacking heme rather than mature heme-bound IDO1 .
Cat. No.: HY-178011
CAS No.: 1219296-74-8
Research Areas:
IDO1-IN-28 (Compound MQ-1) is a Apo-IDO1 inhibitor with an IC50 of 1.29 μM. IDO1-IN-28 selectively targets apo-IDO1 and disrupts heme binding. IDO1-IN-28 can be used for cancers research .
Cat. No.: HY-178024
CAS No.: 1219340-38-1
Research Areas:
IDO1-IN-29 (Compound MQ-1n) is a Apo-IDO1 inhibitor with an IC50 of 0.29 μM. IDO1-IN-29 selectively targets apo-IDO1 and disrupts heme binding. IDO1-IN-29 can be used for cancers research .
Cat. No.: HY-172453
Research Areas:
XW-032 is an apo-IDO1 inhibitor, with an IC50 of 21 nM. XW-032 (TGI = 63%) exhibits potent in vivo anti-tumor efficacy in the CT26 syngeneic mouse model and is expected to be applied in the research of the field of cancer .
Synonyms: (Rac)-IDO1-IN-5
Research Areas:
(Rac)-LY-3381916 ((Rac)-IDO1-IN-5; Example 1) is a racemate of LY-3381916 . LY-3381916 is a potent, selective and brain penetrated inhibitor of Indoleamine 2,3-Dioxygenase 1 (IDO1) activity, binds to apo-IDO1 lacking heme rather than mature heme-bound IDO1 .
Cat. No.: HY-181947
Research Areas:
IDO1-IN-33 (Compound YC-16) is a IDO1 inhibitor (with an IC50 of 0.18 μM for IDO1 in HeLa cells). IDO1-IN-33 acts as an apo-IDO1 inhibitor by slowly and competitively displacing heme from mature holo-IDO1 and rapidly binding to the heme-binding site of immature apo-IDO1, without altering the expression level of IDO1. IDO1-IN-33 can be used for the research of hepatocellular carcinoma, non-small cell lung cancer, triple-negative breast cancer, and cervical cancer .
Cat. No.: HY-111540R
CAS No.: 2166616-75-5
Synonyms: IDO1-IN-5 (Standard)
Research Areas:
LY-3381916 (Standard) is the analytical standard of LY-3381916 (HY-111540). This product is intended for research and analytical applications. LY-3381916 (IDO1-IN-5) is a potent, selective and brain penetrated inhibitor of IDO1 activity, binds to apo-IDO1 lacKing heme rather than mature heme-bound IDO1 .
Cat. No.: HY-111540AR
CAS No.: 2166616-74-4
Synonyms: (Rac)-IDO1-IN-5 (Standard)
Research Areas:
(Rac)-LY-3381916 (Standard) is the analytical standard of (Rac)-LY-3381916 (HY-111540A). This product is intended for research and analytical applications. (Rac)-LY-3381916 ((Rac)-IDO1-IN-5; Example 1) is a racemate of LY-3381916 . LY-3381916 is a potent, selective and brain penetrated inhibitor of Indoleamine 2,3-Dioxygenase 1 (IDO1) activity, binds to apo-IDO1 lacKing heme rather than mature heme-bound IDO1 .
Cat. No.: HY-111540BR
CAS No.: 2166616-76-6
Synonyms: (S)-IDO1-IN-5 (Standard)
Research Areas:
(S)-LY-3381916 (Standard) is the analytical standard of (S)-LY-3381916 (HY-111540B). This product is intended for research and analytical applications. (S)-LY-3381916 ((S)-IDO1-IN-5; Example 1B) is an active S-isomer of LY-3381916. (S)-LY-3381916 binds to IDOL with an IC50 value less than 1.5 µΜ . LY-3381916 is a potent, selective and brain penetrated inhibitor of Indoleamine 2,3-Dioxygenase 1 (IDO1) activity, binds to apo-IDO1 lacKing heme rather than mature heme-bound IDO1 .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
