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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
9 Results for "
COL3
" in MedChemExpress (MCE) Product Catalog:
Products (9)
9 Results for "COL3" in MCE Product Catalog:
12
12 Publications Verification
Synonyms: CMT-3; COL-3
Incyclinide (CMT-3, COL-3) is a matrix metalloproteinase (MMP) inhibitor and inhibiting angiogenesis, tumor growth and invasion, and metastasis.
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1 Cited Publications
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(rel)-AR234960 is a selective and competitive agonist of the G protein-coupled receptor MAS. (rel)-AR234960 binds to the MAS receptor to activate the downstream ERK1/2 signaling pathway, inducing the expression of connective tissue growth factor (CTGF) and its downstream collagen subtype genes (such as COL1A1, COL3A1). (rel)-AR234960 promotes collagen synthesis in cardiac fibroblasts through the MAS-ERK1/2-CTGF pathway and aggravates extracellular matrix remodeling. (rel)-AR234960's in vitro effect can be blocked by the MAS inverse agonist AR244555 and MEK1 inhibitor. (rel)-AR234960 regulates the expression of cardiac fibrosis-related genes and can be used in the study of heart failure .
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1 Cited Publications
Cat. No.: HY-P81101
Synonyms: COL 3A1; COL3A1; COLlagen alpha 1(III) chain; COLlagen III alpha 1 chain precursor; COLlagen III alpha 1 polypeptide; COLlagen type III alpha 1 (Ehlers Danlos syndrome type IV autosomal dominant); COLlagen type III alpha 1; COLlagen type III alpha; EDS4A; Ehlers Danlos syndrome type IV, autosomal dominant; Fetal COLlagen; Type III COLlagen; CO3A1_HUMAN; COLlagen alpha-1(III) chain; Type III COLlagen; type III preproCOLlagen alpha 1 chain.
Cat. No.: HY-RS02982
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COL3A1 Human Pre-designed siRNA Set A contains three designed siRNAs for COL3A1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS17719
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Col3a1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Col3a1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS24184
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Col3a1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Col3a1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-172258
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5-HT2B antagonist-2 (Compound 19c) is a 5HT2B receptor antagonist with an IC50 of 1.09 nM. 5-HT2B antagonist-2 can downregulate the expression of fibrosis-related genes α-SMA, Timp1, Col1a1, and Col3a1, and significantly reduce the deposition of fibrosis, thereby reducing the fibrotic area and inhibiting the fibrotic process in CCl4-induced liver fibrosis mouse models. 5-HT2B antagonist-2 can be used in the study of immune inflammatory-related diseases, particularly in the research of pulmonary fibrosis diseases .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
