Search Result

Results for "

COX-1/2-IN-1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	COX (29) Aldose Reductase (1) Apoptosis (4) Autophagy (4) Drug Metabolite (2) EGFR (1) Endogenous Metabolite (4) Estrogen Receptor/ERR (1) FAAH (4) Interleukin Related (1) Isotope-Labeled Compounds (3) Lipoxygenase (3) NO Synthase (1) OAT (1) PGE synthase (3) Prostaglandin Receptor (1) RAR/RXR (1) Reactive Oxygen Species (ROS) (1) Reference Standards (4) Sirtuin (1) SOD (1) TNF Receptor (1) Xanthine Oxidase (1)
By Research Areas:	Cancer (7) Endocrinology (1) Inflammation/Immunology (25) Metabolic Disease (3) Neurological Disease (2)

By Targets:

COX (29)

Aldose Reductase (1)

Apoptosis (4)

Autophagy (4)

Drug Metabolite (2)

EGFR (1)

Endogenous Metabolite (4)

Estrogen Receptor/ERR (1)

FAAH (4)

Interleukin Related (1)

Isotope-Labeled Compounds (3)

Lipoxygenase (3)

NO Synthase (1)

OAT (1)

PGE synthase (3)

Prostaglandin Receptor (1)

RAR/RXR (1)

Reactive Oxygen Species (ROS) (1)

Reference Standards (4)

Sirtuin (1)

SOD (1)

TNF Receptor (1)

Xanthine Oxidase (1)

By Research Areas:

Cancer (7)

Endocrinology (1)

Inflammation/Immunology (25)

Metabolic Disease (3)

Neurological Disease (2)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: COX

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B1227

Carprofen 5+ Cited Publications	COX FAAH Autophagy Endogenous Metabolite	Inflammation/Immunology
Carprofen is a nonsteroid anti-inflammatory agent, acts as a multi-target FAAH/COX inhibitor, with IC₅₀s of 3.9 μM, 22.3 μM and 78.6 μM for COX-2, COX-1 and FAAH, respectively.

HY-111310

ML351 2 Publications Verification	Lipoxygenase	Neurological Disease Metabolic Disease
ML351 is a potent and highly specific 15-LOX-1 inhibitor with an IC₅₀ of 200 nM. ML351 shows excellent selectivity (>250-fold) versus the related isozymes, 5-LOX, platelet 12-LOX, 15-LOX-2, ovine COX-1, and human COX-2 . ML351 prevents dysglycemia and reduces β-cell oxidative stress in nonobese diabetic mouse model of T1D .

HY-B0367

Lornoxicam Chlortenoxicam; Ro 13-9297	Apoptosis COX NO Synthase Interleukin Related Prostaglandin Receptor TNF Receptor	Inflammation/Immunology Cancer
Lornoxicam (Chlortenoxicam) is an orally active oxycontin nonsteroidal anti-inflammatory drug (NSAID) with analgesic, anti-inflammatory, antipyretic and anticancer activities. Lornoxicam exhibits good inhibitory effects on both *COX-1* and *COX-2* (COX-1: IC₅₀=0.005 μM; COX-2:IC₅₀=0.008 μM) and inhibits the production of NO by iNOS (IC₅₀=65 μM) and the proinflammatory cytokine IL-6 (IC₅₀=54 μM). Lornoxicam also inhibits tumor cell proliferation and migration and induces tumor cell apoptosis. Lornoxicam can be used in the study of inflammatory pain, colorectal cancer and breast cancer .

HY-118827

Vedaprofen Quadrisol; CERM 10202; PM 150	COX	Inflammation/Immunology
Vedaprofen (Quadrisol) is a *COX-1* selective nonsteroidal anti-inflammatory agent (NSAID) for serum TxB2 and exudate *PGE2* inhibition . Vedaprofen is a Escherichia coli (E. coli) sliding clamp (SC) inhibitor with the IC₅₀ of 222 μM .

HY-15123

(S)-Flurbiprofen 2 Publications Verification Esflurbiprofen	COX PGE synthase	Inflammation/Immunology
(S)-Flurbiprofen is an active enantiomer of Flurbiprofen, with IC₅₀ values of 0.48 μM and 0.47 μM for *COX-1* and *COX-2*, respectively .

HY-126848

Diclofenac acyl glucuronide D-1-O-G	Drug Metabolite SOD COX Reactive Oxygen Species (ROS) OAT	Inflammation/Immunology
Diclofenac acyl glucuronide (D-1-O-G) is an orally active glucuronide metabolite of Diclofenac (HY-15036). Diclofenac acyl glucuronide exhibits SOD inhibitory activity, *COX-1* inhibitory activity (IC₅₀ = 0.620 μM), and COX-2 inhibitory activity (IC₅₀ = 2.91 μM). Diclofenac acyl glucuronide induces reactive oxygen species (ROS) production and acts as a substrate of *OATP2B1*. Diclofenac acyl glucuronide induces small intestinal ulcers . Diclofenac acyl glucuronide can be used in research related to intestinal diseases and small intestinal ulcers .

HY-15028

Otenaproxesul ATB-346	COX Apoptosis	Inflammation/Immunology
Otenaproxesul (ATB-346), an orally active non-steroidal anti-inflammatory drug (NSAID), inhibits *cyclooxygenase-1 and 2 (COX-1* and 2)**. Otenaproxesul possesses antiinflammatory and antinociceptive activities .

HY-15123R

(S)-Flurbiprofen (Standard) Esflurbiprofen (Standard)	Reference Standards COX PGE synthase	Inflammation/Immunology
(S)-Flurbiprofen (Standard) is the analytical standard of (S)-Flurbiprofen. This product is intended for research and analytical applications. (S)-Flurbiprofen is an active enantiomer of Flurbiprofen, with IC₅₀ values of 0.48 μM and 0.47 μM for *COX-1* and *COX-2*, respectively .

HY-B1227R

Carprofen (Standard)	Reference Standards COX FAAH Autophagy Endogenous Metabolite	Inflammation/Immunology
Carprofen (Standard) is the analytical standard of Carprofen. This product is intended for research and analytical applications. Carprofen is a nonsteroid anti-inflammatory agent, acts as a multi-target FAAH/COX inhibitor, with IC50s of 3.9 μM, 22.3 μM and 78.6 μM for COX-2, COX-1 and FAAH, respectively.

HY-115966

*COX-1/2-IN-1*	COX	Inflammation/Immunology
COX-1/2-IN-2 is a potent *COX1/2* inhibitor. COX-1/2-IN-2 exhibits significant inhibitory effect against COX-1 and COX-2 inhibitor with IC₅₀ values of 13.9 ± 3.21 µM and 6.4±0.74 µM, respectively ^[1].

HY-151173

XO/COX/LOX-IN-1	Xanthine Oxidase Lipoxygenase COX	Metabolic Disease Inflammation/Immunology
XO/COX/LOX-IN-1 is a XO/COX/LOX inhibitor with an IC₅₀ of 3.2 μM against rat XO, 10.83 μM against 5-LOX, 12.67 μM against *COX-1, and 8.31 μM against COX-2*. XO/COX/LOX-IN-1 binds to the active sites of XO, 5-LOX, *COX-1* and COX-2, thereby blocking enzyme activities associated with uric acid, leukotriene, prostaglandin synthesis and inflammatory pathways. XO/COX/LOX-IN-1 can be used in the research of hyperuricemia and inflammation .

HY-B1227S

Carprofen-d3	COX FAAH Autophagy Endogenous Metabolite	Inflammation/Immunology
Carprofen-d₃ is the deuterium labeled Carprofen. Carprofen is a nonsteroid anti-inflammatory agent, acts as a multi-target FAAH/COX inhibitor, with IC50s of 3.9 μM, 22.3 μM and 78.6 μM for COX-2, COX-1 and FAAH, respectively.

HY-136720

ZXX2-77	COX	Others
ZXX2-77 is a cyclooxygenase-1 (COX-1) selective inhibitor belonging to the benzenesulfonylanilide class of compounds. It is reported as a novel analgesic that does not cause gastric damage. ZXX2-77 has a weak analgesic effect but exhibits potent COX-1 inhibitory activity in vitro. The low oral absorption rate of ZXX2-77 leads to its weak analgesic effect in vivo. At a dose of 30 mg/kg, the maximum plasma concentration of ZXX2-77 (1.2 mM) did not reach its COX-1 IC50 value (3.2 mM). In contrast, its derivative ZXX2-79, although weaker in vitro COX inhibitory activity, is better absorbed, exhibits stronger analgesic effect and hardly causes gastric damage. These findings suggest that ZXX2-77 and its derivatives as COX-1 selective inhibitors may become effective analgesics that do not cause gastric damage.

HY-B0580S

Ketorolac-d5	COX	Inflammation/Immunology
Ketorolac-d₅ is a deuterium labeled Ketorolac. Ketorolac is a non-steroidal anti-inflammatory agent, acting as a nonselective COX inhibitor, with IC₅₀s of 20 nM for COX-1 and 120 nM for COX-2 .

HY-119671

BW 755C	COX Lipoxygenase	Endocrinology
BW 755C is a 5-lipoxygenase (5-LO) inhibitor with an IC₅₀ of 5 μM. BW 755C also inhibits cyclooxygenase (COX) with IC₅₀s of 0.65 and 1.2 μg/mL against COX-1 and COX-2, respectively .

HY-B0253S

Piroxicam-d3 CP-16171 d₃	COX	Inflammation/Immunology Cancer
Piroxicam-d₃ (CP-16171-d₃) is deuterium labeled Piroxicam. Piroxicam is a non-steroidal anti-inflammatory drugs, acts as a COX inhibitor, with IC₅₀s of 47, 25 μM for human monocyte COX-1 and COX-2, respectively .

HY-B0253A

Piroxicam olamine CP-16171 olamINe	COX	Inflammation/Immunology Cancer
Piroxicam olamine (CP-16171) is a non-steroidal anti-inflammatory drugs, acts as a COX inhibitor, with IC₅₀s of 47, 25 μM for human monocyte COX-1 and COX-2, respectively .

HY-Z4707

Etoricoxib N1'-oxide	Drug Metabolite	Others
Etoricoxib N1'-oxide is an Etoricoxib (HY-15321) metabolite. Etoricoxib N1'-oxide does not inhibit COX-1, nor does it significantly inhibit COX-2 .

HY-162173

WYZ90	COX	Inflammation/Immunology
WYZ90 ((compound 6a) is a potent and selective COX-2 inhibitor with IC₅₀ values of 75, 5734, 19940 nM for COX-2, COX-1 and DPPH, respectively. WYZ90 shows antioxidant and analgesic activity .

HY-153980

K-80001	RAR/RXR COX	Inflammation/Immunology
K-80001 is an RXRα-binder and *COX-1/2* inhibitor, with IC₅₀s of with an IC₅₀ of 82.9μM, 3.4μM, 1.2μM for RXRα, COX-1 and COX-2, respectively .

HY-161862

COX-2-IN-44	COX	Inflammation/Immunology
COX-2-IN-44 is a potent and orally active COX-2 inhibitor with IC₅₀ values of 0.18,1.14 µM for COX-2, COX-1, respectively. COX-2-IN-44 shows anti-inflammatory activity .

HY-B0578S

Loxoprofen-d4	Isotope-Labeled Compounds COX	Inflammation/Immunology
Loxoprofen-d₄ is deuterium labeled Loxoprofen. Loxoprofen is a non-steroidal anti-inflammatory agent with analgesic and anti-pyretic properties. Loxoprofen sodium is a nonselective COX inhibitor with IC₅₀s of 6.5 and 13.5 μM for COX-1 and COX-2, respectively .

HY-15028R

Otenaproxesul (Standard) ATB-346 (Standard)	COX Apoptosis Reference Standards	Inflammation/Immunology
Otenaproxesul (Standard) is the analytical standard of Otenaproxesul. This product is intended for research and analytical applications. Otenaproxesul (ATB-346), an orally active non-steroidal anti-inflammatory drug (NSAID), inhibits cyclooxygenase-1 and 2 (COX-1 and 2). Otenaproxesul possesses antiinflammatory and antinociceptive activities .

HY-118827S

Vedaprofen-d3	Isotope-Labeled Compounds COX	Inflammation/Immunology
Vedaprofen-d₃ is the deuterium labeled Vedaprofen. Vedaprofen (Quadrisol) is a COX-1 selective nonsteroidal anti-inflammatory agent (NSAID) for serum TxB2 and exudate PGE2 inhibition . Vedaprofen is a Escherichia coli (E. coli) sliding clamp (SC) inhibitor with the IC₅₀ of 222 μM .

HY-118827R

Vedaprofen (Standard) Quadrisol (Standard); CERM 10202 (Standard); PM 150 (Standard)	Reference Standards COX	Inflammation/Immunology
Vedaprofen (Standard) is the analytical standard of Vedaprofen. This product is intended for research and analytical applications. Vedaprofen (Quadrisol) is a COX-1 selective nonsteroidal anti-inflammatory agent (NSAID) for serum TxB2 and exudate PGE2 inhibition . Vedaprofen is a Escherichia coli (E. coli) sliding clamp (SC) inhibitor with the IC₅₀ of 222 μM .

HY-162425

Anti-inflammatory agent 78	PGE synthase COX	Inflammation/Immunology Cancer
Anti-inflammatory agent 78 (compound L-37) is a potent anti-inflammatory agent. Anti-inflammatory agent 78 has significant potency on PGE2, PGE1, COX-2 and COX-1 inhibition. Anti-inflammatory agent 78 can inhibits NO release in LPS-stimulated RAW 264.7 cell line .

HY-B1227S1

Carprofen-13C,d3	FAAH COX Autophagy Endogenous Metabolite	Inflammation/Immunology
Carprofen- ¹³C,d₃ is the deuterium and ¹³C labeled Carprofen . Carprofen is a nonsteroid anti-inflammatory agent, acts as a multi-target FAAH/COX inhibitor, with IC₅₀s of 3.9 μM, 22.3 μM and 78.6 μM for COX-2, COX-1 and FAAH, respectively .

HY-170932

EGFR/COX-2-IN-1	EGFR COX Apoptosis	Cancer
EGFR/COX-2-IN-1 is an EGFR/COX-2 inhibitor. EGFR/COX-2-IN-1 inhibits EGFR ^WT, EGFR ^T790M, *COX-1* and COX-2 with IC₅₀s of 0.12, 0.076, 20.1 and 1.52 μM respectively. EGFR/COX-2-IN-1 inhibits and with IC₅₀s of , respectively. EGFR/COX-2-IN-1 inhibits MCF-7, HT-29 and A-549 with IC₅₀s of 1.20, 5.14 and 14.81 μM, respectively. EGFR/COX-2-IN-1 displays Apoptosis induction by up-regulating Bax and down-regulating Bcl-2 protein levels. EGFR/COX-2-IN-1 results in a significant increase in the percentage of cells at the G2/M in MFC-7 cells. EGFR/COX-2-IN-1 exhibits broad-spectrum antitumor effects .

HY-160184

COX-1-IN-5	COX	Neurological Disease Inflammation/Immunology
COX-1-IN-5 (example 13, compound PS13) is a potent and selective *COX-1* inhibitor (COX-1 IC₅₀ = 1 nM, COX-2 IC₅₀ > 0.1 μM) exhibiting >1000-fold selectivity over *COX-2*. COX-1-IN-5 possesses strong anti-inflammatory, antipyretic, analgesic, antithrombotic, anti-cancer activities. COX-1-IN-5 can be used for COX-mediated diseases research, such as inflammatory conditions and pain. COX-1-IN-5 radiolabeled with ¹¹C can be used as a selective PET tracer for whole‑body imaging of COX‑1 distribution and target engagement in vivo .

HY-183187

4H-Chromen-4-one-o-carborane	Estrogen Receptor/ERR COX	Cancer
4H-Chromen-4-one-o-carborane is an estrogen receptor (ER) agonist, with an EC₅₀ of 0.9 μM for ERα and an EC₅₀ of 11.1 μM for ERβ. 4H-Chromen-4-one-o-carborane also acts as an inhibitor of *COX-1* and COX-2, with an IC₅₀ of 6.6 μM for *COX-1* and an IC₅₀ of 17.7 μM for *COX-2* .

HY-B0580S1

Ketorolac-d4	Isotope-Labeled Compounds COX	Inflammation/Immunology
Ketorolac-d₄ (RS37619 D₄) is the deuterium labeled Ketorolac. Ketorolac is a non-steroidal anti-inflammatory agent, acting as a nonselective COX inhibitor, with IC₅₀s of 20 nM for COX-1 and 120 nM for COX-2 .

HY-183044

SIRT1 activator 4	Sirtuin	Metabolic Disease
SIRT1 activator 4 is an orally active, NAD ⁺-independent SIRT1 activator. SIRT1 activator 4 is also an analog of (E)-2'-desmethyl Sulindac (HY-B0008), with weak or negligible inhibitory activity against *COX-1* and no inhibitory activity against *COX-2*. SIRT1 activator 4 can be used for the research of metabolic diseases .

HY-124432

CRT0093964	Aldose Reductase	Cancer
CRT0093964 is an isoform-selective non-carboxylate inhibitor of AKR1C3 (IC₅₀=0.11 μM) with no activity against AKR1C1, *AKR1C2, AKR1C4*, *COX-1, and COX-2*.CRT0093964 can be used for the research of leukemia, hormone-related cancers, colon cancer .

Cat. No.	Product Name	Category	Target	Chemical Structure