2 Results for "

CRL5 complex

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "CRL5 complex" in MCE Product Catalog:

1
MN551
MN551
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1 Cited Publications
Cat. No.: HY-156395
CAS No.: 3044099-90-0
Purity:  98.05%
Target:  

E1/E2/E3 Enzyme

Research Areas:  

Others

MN551 is a covalent modulator of SOCS2 and CISH, with selectivity for SOCS2 and CISH over SOCS4. MN551 covalently modifies Cys111 in the SH2 domain of SOCS2 and Cys144 in the EF loop of the CISH SH2 domain, while only minimally modifying Cys471 in the BG loop of the SOCS6 SH2 domain. MN551 increases the thermal stability of the recombinant SOCS2-ElonginB-ElonginC complex and competitively blocks the binding of SOCS2 to its substrate; when delivered via the prodrug MN714, it blocks the intracellular recruitment of substrates by SOCS2. MN551 can serve as a chemical probe for investigating the biological functions of SOCS2 and its CRL5 complex, and also act as an E3 ligase-binding module in proteolysis-targeting chimeras (PROTACs) .
MN714
MN714
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Cat. No.: HY-156373
Target:  

E1/E2/E3 Enzyme Drug Intermediate Ligands for E3 Ligase

Research Areas:  

Cancer

MN714 is a prodrug of MN551 (HY-156395) with enhanced cell permeability. MN714 specifically and covalently binds to SOCS2 within living cells, with an EC50 of 3.77 μM at 2 h and 2.52 μM at 8 h. MN714 serves as a chemical probe for investigating the biological mechanisms of the SOCS2 and CRL5 complex, and also functions as an E3 ligase linker for PROTAC development .
Assay Types