1 Result for "

CTX009

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "CTX009" in MCE Product Catalog:

Cat. No.: HY-P991033
CAS No.: 2923284-73-3
Synonyms: CTX-009; ES 104
Target:  

VEGFR Notch

Research Areas:  

Cancer

Tovecimig (CTX-009) is a bispecific antibody targeting DLL4 and VEGF-A. Tovecimig contains two single-chain variable fragments (scFv) that bind human DLL4, and these fragments are linked to the C-terminus of the heavy chain that binds human VEGF-A. Tovecimig blocks the DLL4/NOTCH1 and VEGF signaling pathways, inhibiting DLL4-mediated Notch signaling and VEGF-A-mediated angiogenic signaling in tumor angiogenesis. Tovecimig can be used in research on refractory metastatic colorectal cancer, advanced biliary tract cancer, solid tumors, gastric cancer, and colon cancer .
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