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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
7 Results for "
CatSper
" in MedChemExpress (MCE) Product Catalog:
Products (7)
7 Results for "CatSper" in MCE Product Catalog:
2
2 Cited Publications
Synonyms: 3,4-Bis(2-thienoyl)-1,2,5-oxadiazole-N-oxide
Target:
Research Areas:
HC-056456 is an effective but not perfectly-selective blocker of CatSper channels. The [Na +]i rise is slowed by HC-056456 (IC50~3 µM).
Cat. No.: HY-18740A
CAS No.: 78416-81-6
Synonyms: HL 725
Target:
Research Areas:
Trequinsin hydrochloride (HL 725) is a PDE inhibitor, CatSper channel activator, and sperm potassium channel modulator. Trequinsin hydrochloride targets PDE3 with an IC50 of <1 nM. Trequinsin hydrochloride enhances currents and elevates intracellular calcium and cGMP levels via direct activation of the CatSper channel, while inhibiting the outward current conductance of sperm potassium channels. Without inducing premature acrosome reaction, Trequinsin hydrochloride significantly enhances sperm hyperactivated motility, forward motility, and the ability to penetrate viscous media. Trequinsin hydrochloride exerts age-specific positive inotropic and positive lusitropic effects on rabbit ventricular papillary muscles. Trequinsin hydrochloride has been used in studies on the mechanisms underlying male infertility (e.g., asthenozoospermia) .
Cat. No.: HY-RS01984
Target:
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CATSPER1 Human Pre-designed siRNA Set A contains three designed siRNAs for CATSPER1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-113096
CAS No.: 17968-82-0
Synonyms: PGD1
Target:
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Prostaglandin D1 (PGD1) is a CatSper activator that triggers Ca 2+ influx through sperm-specific Ca 2+ channels via the prostaglandin binding site and competes with other prostaglandins .
Cat. No.: HY-RS01985
Target:
Research Areas:
CATSPER2 Human Pre-designed siRNA Set A contains three designed siRNAs for CATSPER2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-113096S
Synonyms: PGD1-d4
Research Areas:
Prostaglandin D1-d4 (PGD1-d4) is the d4-labeled Prostaglandin D1 (HY-113096). Prostaglandin D1 (PGD1) is a CatSper activator that triggers Ca 2+ influx through sperm-specific Ca 2+ channels via the prostaglandin binding site and competes with other prostaglandins .
Cat. No.: HY-18740
CAS No.: 79855-88-2
Synonyms: HL 725 free base
Target:
Research Areas:
Trequinsin (HL 725 free base) is a PDE inhibitor, CatSper channel activator, and sperm potassium channel modulator. Trequinsin targets PDE3 with an IC50 of <1 nM. Trequinsin enhances currents and elevates intracellular calcium and cGMP levels via direct activation of the CatSper channel, while inhibiting the outward current conductance of sperm potassium channels. Without inducing premature acrosome reaction, Trequinsin significantly enhances sperm hyperactivated motility, forward motility, and the ability to penetrate viscous media. Trequinsin exerts age-specific positive inotropic and positive lusitropic effects on rabbit ventricular papillary muscles. Trequinsin has been used in studies on the mechanisms underlying male infertility (e.g., asthenozoospermia) .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
