Search Result

Pathways Recommended:	Membrane Transporter/Ion Channel

Results for "

Cyclic nucleotide-gated channel

" in MedChemExpress (MCE) Product Catalog:

By Targets:	HCN Channel (17) Adenylate Cyclase (2) Biochemical Assay Reagents (1) Drug Derivative (1) Drug Metabolite (4) Fluorescent Dye (1) Isotope-Labeled Compounds (1) Nucleoside Antimetabolite/Analog (1) Olfactory Receptor (1) PKA (1) PKG (2) Potassium Channel (2) Reference Standards (3)
By Research Areas:	Cancer (5) Cardiovascular Disease (10) Endocrinology (1) Infection (1) Inflammation/Immunology (1) Metabolic Disease (2) Neurological Disease (12)

Inhibitors & Agonists

Isotope-Labeled Compounds

Targets Recommended: HCN Channel Cyclic GMP-AMP Synthase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0162A

Ivabradine hydrochloride 3 Publications Verification	HCN Channel	Cardiovascular Disease Infection Neurological Disease Metabolic Disease Cancer
Ivabradine hydrochloride is a potent and orally active HCN (hyperpolarization-activated cyclic nucleotide-gated) channel blocker that inhibits the cardiac pacemaker current (If). Ivabradine hydrochloride reduces dose-dependently heart rate without modification of blood pressure. Ivabradine hydrochloride shows anticonvulsant, anti-ischaemic and anti-anginal activity .

HY-101346

ZD7288 Maximum Cited Publications 9 Publications Verification ICI D7288	HCN Channel	Neurological Disease
ZD7288 (ICI D7288) is a selective hyperpolarization-activated cyclic nucleotide-gated (HCN) channel blocker .

HY-N6789

KT5720 4 Publications Verification	PKA	Neurological Disease Cancer
KT5720 is a potent, cell-permeable, specific, reversible and ATP-competitive PKA inhibitor (IC₅₀=3.3 μM). KT5720 is effective in reversing MDR1-mediated multidrug resistance. KT5720 also reduces the excitability of dorsal root ganglion (DRG) neurons by attenuating Hyperpolarization-activated cyclic nucleotide-gated (HCN) channel activity and reducing intracellular Ca2 ⁺ concentrations. KT5720 can be used in the study of haematological malignancies as well as HCN and DRG neuron-related diseases .

HY-B0162

Ivabradine 3 Publications Verification	HCN Channel	Cardiovascular Disease Cancer
Ivabradine is a potent and orally active HCN (hyperpolarization-activated cyclic nucleotide-gated) channel blocker that inhibits the cardiac pacemaker current (If). Ivabradine reduces dose-dependently heart rate without modification of blood pressure. Ivabradine shows anticonvulsant, anti-ischaemic and anti-anginal activity .

HY-172550

MS7710	HCN Channel	Neurological Disease
MS7710 is a hyperpolarization-activated cyclic nucleotide-gated (HCN) channel inhibitor with blood-brain barrier permeability and an excellent brain/plasma concentration ratio. MS7710 inhibits HCN channel-mediated I_h current, and reduces the firing frequency and burst activity of dopaminergic neurons in the ventral tegmental area. MS7710 ameliorates chronic social defeat stress-induced deficits in social interaction and impairments in reward-related cognitive flexibility in mice. MS7710 exerts only limited effects on ventral tegmental area dopaminergic neuron activity, social interaction, exploratory behavior, locomotor activity or sucrose preference in control mice. MS7710 is applicable to the research of major depressive disorder .

HY-13422

Zatebradine hydrochloride 2 Publications Verification UL-FS-49; UL-FS-49CL	HCN Channel	Cardiovascular Disease
Zatebradine (UL-FS-49 (free base)) is a potent inhibitor of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels with an IC₅₀ values 1.96 µM. Zatebradine blocks the slow inward current through human HCN1, HCN2, HCN3 and HCN4 channels, with IC₅₀ values of 1.83 µM, 2.21 µM, 1.90 µM and 1.88 µM, respectively .

HY-13422A

Zatebradine 2 Publications Verification UL-FS-49 free base; UL-FS-49CL free base	HCN Channel	Cardiovascular Disease
Zatebradine (UL-FS-49 (free base); UL-FS-49CL (free base)) is a potent inhibitor of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels with an IC₅₀ value of 1.96 µM. Zatebradine blocks the slow inward current through human HCN1, HCN2, HCN3 and HCN4 channels, with IC₅₀ values of 1.83 µM, 2.21 µM, 1.90 µM and 1.88 µM, respectively .

HY-163455

pan-HCN-IN-1	HCN Channel	Neurological Disease
pan-HCN-IN-1 (Compound J&J12e) is an inhibitor for hyperpolarization-activated and cyclic-nucleotide-gated 1 (HCN1) ion channel, with IC₅₀ of 58 nM. pan-HCN-IN-1 reduces the voltage sag response and enhances EPSP summation in ex vivo rats brain slices .

HY-137016A

8-Pcpt-cGMP sodium 1 Publications Verification	HCN Channel	Neurological Disease
8-Pcpt-cGMP sodium is the sodium salt form of 8-Pcpt-cGMP (HY-137016). 8-Pcpt-cGMP sodium is an agonist for cyclic nucleotide-gated (CNG) channel with an EC₅₀ of 0.5 μM. 8-Pcpt-cGMP sodium exhibits good membrane permeability. 8-Pcpt-cGMP sodium can be used in studies about the function of CNG channels in visual signal transduction and olfactory transduction .

HY-108548

Rp-8-Br-PET-cGMPS sodium Rp-8-Bromo-PET-cGMPS	PKG	Inflammation/Immunology
Rp-8-Br-PET-cGMPS sodium (Rp-8-Bromo-PET-cGMPS) is an analog of cyclic GMP (cGMP). It is a cell permeable, competitive, and reversible inhibitor of cGMP-dependent protein kinases (cGKs) that blocks activation of cGKI and cGKII by cGMP (Kis=35 and 30 nM). It less potently inhibits protein kinase A (Ki=11 μM) and cGMP-induced activation of cyclic nucleotide-gated channels (IC₅₀=25 μM). In the absence of cGMP stimulation, Rp-8-bromo-PET-cGMPS can act as a partial agonist of cGKI (Ki=1 μM). Rp-8-bromo-PET-cGMPS is resistant to hydrolysis by phosphodiesterase 11.

HY-161092

KIO-301 chloride	HCN Channel Potassium Channel	Neurological Disease
KIO-301 chloride is an azobenzene photoswitch compound that can block voltage-gated ion channels, including *hyperpolarisation-activated cyclic* nucleotide-gated (HCN)** and voltage-gated potassium channels during exposure to visible light .

HY-110221

Rp-8-pCPT-cGMPS sodium 1 Publications Verification	PKG	Neurological Disease
Rp-8-pCPT-cGMPS sodium is the sodium salt form of Rp-8-pCPT-cGMPS. Rp-8-pCPT-cGMPS is an inhibitor for cGMP-dependent protein kinase (cGK). Rp-8-pCPT-cGMPS sodium is an agonist for cyclic nucleotide-gated (CNG) channels in a voltage-dependent manner .

HY-161092A

KIO-301 chloride hydrochloride	HCN Channel Potassium Channel	Neurological Disease
KIO-301 chloride hydrochloride is an azobenzene photoswitchable compound that blocks voltage-gated ion channels, including hyperpolarization-activated cyclic nucleotide gating (HCN, during exposure to visible light) ) and voltage-gated potassium channels (voltage-gated potassium channels) .

HY-W097929

Tyrene 2,4,6-Trichloroanisole	Olfactory Receptor Drug Metabolite Biochemical Assay Reagents HCN Channel	Others
Tyrene (2,4,6-Trichloroanisole) is an off-flavor compound, cyclic nucleotide-gated (CNG) channel inhibitor, and olfactory transduction attenuator. Tyrene is formed by microbial O-methylation of 2,4,6-trichlorophenol. Tyrene inhibits channel activity in olfactory receptor cells by partitioning into the plasma membrane lipid bilayer, and also suppresses odorant- and cAMP-induced currents in individual olfactory receptor cells. Tyrene causes cork taint in wine. Tyrene also produces off-flavors in potato chips, dried fruits, coffee, and drinking water .

HY-137016

8-Pcpt-cGMP	HCN Channel	Neurological Disease
8-Pcpt-cGMP is an agonist for cyclic nucleotide-gated (CNG) channel with an EC₅₀ of 0.5 μM. 8-Pcpt-cGMP exhibits good membrane permeability. 8-Pcpt-cGMP can be used in studies about the function of CNG channels in visual signal transduction and olfactory transduction .

HY-116540A

L 858051 dihydrochloride 7DMB-Forskolin	Adenylate Cyclase	Cardiovascular Disease
L 858051 (7DMB-Forskolin) dihydrochloride, an analog of Forskolin (HY-15371), is an adenylyl cyclase stimulator. L 858051 dihydrochloride directly activates adenylyl cyclase to increase intracellular, cellular, and ciliary cAMP levels. L 858051 dihydrochloride activates recombinant cyclic nucleotide-gated (E583M CNGA2) channels to induce a non-selective, Mg ²⁺-sensitive current in adult rat ventricular myocytes. L 858051 dihydrochloride maximally stimulates L-type Ca ²⁺ current in adult rat ventricular myocytes. L 858051 dihydrochloride increases total PDE3 and PDE4 activities in adult rat ventricular myocytes, with effects insensitive to PKA inhibition. L 858051 dihydrochloride serves as a tool to elevate intracellular cAMP for studying subsarcolemmal cAMP dynamics and compartmentation in adult rat ventricular myocytes .

HY-131281

Ivabradine impurity 1	Drug Metabolite	Others
Ivabradine impurity 1 is an Ivabradine impurity. Ivabradine is an orally bioavailable, hyperpolarization-activated, cyclic nucleotide-gated (HCN) channel blocker .

HY-131282

Ivabradine impurity 2	Drug Metabolite	Others
Ivabradine impurity 2 is an Ivabradine impurity. Ivabradine is an orally bioavailable, hyperpolarization-activated, cyclic nucleotide-gated (HCN) channel blocker .

HY-131283

8-Demethyl Ivabradine	Drug Metabolite	Endocrinology
8-Demethyl Ivabradine is a metabolite of Ivabradine. Ivabradine is an orally bioavailable, hyperpolarization-activated, cyclic nucleotide-gated (HCN) channel blocker .

HY-116540

L 858051 7DMB-Forskolin free base	Adenylate Cyclase	Cardiovascular Disease
L 858051 (7DMB-Forskolin free base), an analog of Forskolin (HY-15371), is an adenylyl cyclase stimulator. L 858051 directly activates adenylyl cyclase to increase intracellular, cellular, and ciliary cAMP levels. L 858051 activates recombinant cyclic nucleotide-gated (E583M CNGA2) channels to induce a non-selective, Mg ²⁺-sensitive current in adult rat ventricular myocytes. L 858051 maximally stimulates L-type Ca ²⁺ current in adult rat ventricular myocytes. L 858051 increases total PDE3 and PDE4 activities in adult rat ventricular myocytes, with effects insensitive to PKA inhibition. L 858051 serves as a tool to elevate intracellular cAMP for studying subsarcolemmal cAMP dynamics and compartmentation in adult rat ventricular myocytes .

HY-B0162S

Ivabradine-d6	Isotope-Labeled Compounds HCN Channel	Cardiovascular Disease
Ivabradine-d₆ is the deuterium labeled Ivabradine . Ivabradine is a potent and orally active HCN (hyperpolarization-activated cyclic nucleotide-gated) channel blocker that inhibits the cardiac pacemaker current (If). Ivabradine reduces dose-dependently heart rate without modification of blood pressure. Ivabradine shows anticonvulsant, anti-ischaemic and anti-anginal activity .

HY-B0162AR

Ivabradine hydrochloride (Standard)	Reference Standards HCN Channel	Cardiovascular Disease Metabolic Disease Cancer
Ivabradine hydrochloride (Standard) is the analytical standard of Ivabradine hydrochloride. This product is intended for research and analytical applications. Ivabradine hydrochloride is a potent and orally active HCN (hyperpolarization-activated cyclic nucleotide-gated) channel blocker that inhibits the cardiac pacemaker current (If). Ivabradine hydrochloride reduces dose-dependently heart rate without modification of blood pressure. Ivabradine hydrochloride shows anticonvulsant, anti-ischaemic and anti-anginal activity .

HY-13422R

Zatebradine hydrochloride (Standard) UL-FS-49 (Standard); UL-FS-49CL (Standard)	HCN Channel Reference Standards	Cardiovascular Disease
Zatebradine (hydrochloride) (Standard) is the analytical standard of Zatebradine (hydrochloride). This product is intended for research and analytical applications. Zatebradine (UL-FS-49 (free base)) is a potent inhibitor of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels with an IC50 values 1.96 μM. Zatebradine blocks the slow inward current through human HCN1, HCN2, HCN3 and HCN4 channels, with IC50 values of 1.83 μM, 2.21 μM, 1.90 μM and 1.88 μM, respectively .

HY-101346R

ZD7288 (Standard) ICI D7288 (Standard)	HCN Channel Reference Standards	Neurological Disease
ZD7288 (Standard) is the analytical standard of ZD7288 (HY-101346). This product is intended for research and analytical applications. ZD7288 (ICI D7288) is a selective hyperpolarization-activated cyclic nucleotide-gated (HCN) channel blocker .

HY-B0162B

Ivabradine sulfate	HCN Channel	Cardiovascular Disease Neurological Disease Cancer
Ivabradine sulfate is a potent and orally active HCN (hyperpolarization-activated cyclic nucleotide-gated) channel blocker that inhibits the cardiac pacemaker current (If). Ivabradine sulfate reduces dose-dependently heart rate without modification of blood pressure. Ivabradine sulfate shows anticonvulsant, anti-ischaemic and anti-anginal activity .

HY-175080

8-DY547-cGMP	Drug Derivative Fluorescent Dye	Others
8-DY547-cGMP is a fluorescent cGMP analogue composed of a dye DY547 to position 8 of cGMP. 8-DY547-cGMP is a Cyclic nucleotide-gated A2 (CNGA2) ligand. 8-DY547-cGMP can activated CNGA2 channel. 8-DY547-cGMP can be used for simultaneously detection CNG channel activation and ligand binding .

HY-180473

6-Thio-cGMP	Nucleoside Antimetabolite/Analog	Others
6-Thio-cGMP is an analog of cyclic guanosine monophosphate (cGMP) .

Cat. No.	Product Name	Chemical Structure

HY-B0162S

Ivabradine-d6
Ivabradine-d₆ is the deuterium labeled Ivabradine . Ivabradine is a potent and orally active HCN (hyperpolarization-activated cyclic nucleotide-gated) channel blocker that inhibits the cardiac pacemaker current (If). Ivabradine reduces dose-dependently heart rate without modification of blood pressure. Ivabradine shows anticonvulsant, anti-ischaemic and anti-anginal activity .

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

Name
Email *

	Sorry, but the email address you supplied was invalid.