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DHICA

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By Targets:	Arrestin (2) DNA/RNA Synthesis (2) Drug Intermediate (2) Endogenous Metabolite (2) GPR35 (2) Nucleoside Antimetabolite/Analog (1) Reference Standards (1) SOD (2)
By Research Areas:	Cancer (2) Metabolic Disease (1)

Inhibitors & Agonists

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Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W018158

*DHICA* 5,6-Dihydroxyindole-2-carboxylic acid	Endogenous Metabolite GPR35 Arrestin DNA/RNA Synthesis Drug Intermediate SOD	Cancer
DHICA (5,6-Dihydroxyindole-2-carboxylic acid) is an eumelanin building block, GPR35 agonist and melanin synthesis intermediate. DHICA activates GPR35, triggering dynamic mass redistribution and β-arrestin translocation. DHICA interacts with DNA and interferes with Fpg activity . DHICA promotes the generation of single-strand breaks in plasmid DNA. DHICA increases the activity and expression levels of SOD and Catalase. DHICA is applicable to research related to skin cancer and colon cancer .

HY-W018158R

DHICA (Standard) 5,6-Dihydroxyindole-2-carboxylic acid (Standard)	Reference Standards Endogenous Metabolite GPR35 Arrestin DNA/RNA Synthesis Drug Intermediate SOD	Cancer
DHICA (Standard) is an analytical standard of DHICA (HY-W018158). This product is for research and analytical applications. DHICA (5,6-Dihydroxyindole-2-carboxylic acid) is an eumelanin building block, GPR35 agonist and melanin synthesis intermediate. DHICA activates GPR35, triggering dynamic mass redistribution and β-arrestin translocation. DHICA interacts with DNA and interferes with Fpg activity . DHICA promotes the generation of single-strand breaks in plasmid DNA. DHICA increases the activity and expression levels of SOD and Catalase. DHICA is applicable to research related to skin cancer and colon cancer .

HY-180742

5,6-Indolequinone-2-carboxylic acid	Nucleoside Antimetabolite/Analog	Metabolic Disease
5,6-Indolequinone-2-carboxylic acid is an oxidation product of 5,6-dihydroxyindole-2-carboxylic acid (DHICA), an indole intermediate .

5,6-Indolequinone-2-carboxylic acid	Structural Classification Alkaloids Endogenous metabolite Indole Alkaloids Source Classification	Nucleoside Antimetabolite/Analog
5,6-Indolequinone-2-carboxylic acid is an oxidation product of 5,6-dihydroxyindole-2-carboxylic acid (DHICA), an indole intermediate .

Host:	Rabbit (2)
Reactivity:	Human (2)
Application:	IHC-P (2)
Isotype:	IgG (2)
Conjugation:	Non-conjugated (2)
Clonality:	Monoclonal (1) Recombinant (1)
Modification:	Unmodified (1)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P81502

	TRP1 Antibody (YA1247) CAS2; CATB; GP75; OCA3; TRP1; TYRP; TYRP1; TYRRP; DHICA oxidase	IHC-P	Human
	TRP1 Antibody (YA1247) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to TRP1.

HY-P81502A

	TRP1 Antibody (YA1247)(PBS only) CAS2; CATB; GP75; OCA3; TRP1; TYRP; TYRP1; TYRRP; DHICA oxidase	IHC-P	Human
	TRP1 Antibody (YA1247) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to TRP1.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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DHICA

Inhibitors & Agonists

NaturalProducts

Antibodies

Natural
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