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Dectin-2

" in MedChemExpress (MCE) Product Catalog:

By Targets:	C-type Lectin-like Receptors (CTLRs) (1) Sirtuin (1) Small Interfering RNA (siRNA) (1)
By Research Areas:	Cancer (1) Inflammation/Immunology (1)
Oligonucleotides:	Human Pre-designed siRNA Sets (1) siRNAs (1)

Inhibitors & Agonists

Biochemical Assay Reagents

Inhibitory Antibodies

Recombinant Proteins

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W145481A

D-Galacto-D-mannan Carob galactomannan	Sirtuin	Inflammation/Immunology
D-Galacto-D-mannan (Carob galactomannan) is an orally active *Dectin-2* agonist. D-Galacto-D-mannan exerts antioxidant activity against hydroxyl radical generation. D-Galacto-D-mannan activates *Dectin-2* to trigger downstream signaling pathways, promote the expression of immunoregulatory molecules, coordinate innate and adaptive immune responses, and inhibit excessive inflammatory responses by upregulating the expression of Sirtuin 1. When used as a vaccine adjuvant, D-Galacto-D-mannan induces cellular and humoral immune responses, promotes IFNγ secretion, increases antibody levels and virus neutralization titers, and elevates the levels of immunoglobulin G and A. D-Galacto-D-mannan can serve as an adjuvant for foot-and-mouth disease vaccines, enhance the vaccine-mediated ability of hosts to defend against viral infection in mice, and reduce local side effects at the inoculation site in pigs. D-Galacto-D-mannan can be used in the research of inflammatory and immune diseases, such as foot-and-mouth disease .

HY-P991733

BDC-3042	C-type Lectin-like Receptors (CTLRs)	Cancer
BDC-3042 is a Dectin-2 agonistic antibody. BDC-3042 can be used for the research of cancer .

HY-RS02799

CLEC6A Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
CLEC6A Human Pre-designed siRNA Set A contains three designed siRNAs for CLEC6A gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CLEC6A Human Pre-designed siRNA Set A CLEC6A Human Pre-designed siRNA Set A

Cat. No.	Product Name	Type

HY-W145481A

D-Galacto-D-mannan Carob galactomannan	Biochemical Assay Reagents
D-Galacto-D-mannan (Carob galactomannan) is an orally active *Dectin-2* agonist. D-Galacto-D-mannan exerts antioxidant activity against hydroxyl radical generation. D-Galacto-D-mannan activates *Dectin-2* to trigger downstream signaling pathways, promote the expression of immunoregulatory molecules, coordinate innate and adaptive immune responses, and inhibit excessive inflammatory responses by upregulating the expression of Sirtuin 1. When used as a vaccine adjuvant, D-Galacto-D-mannan induces cellular and humoral immune responses, promotes IFNγ secretion, increases antibody levels and virus neutralization titers, and elevates the levels of immunoglobulin G and A. D-Galacto-D-mannan can serve as an adjuvant for foot-and-mouth disease vaccines, enhance the vaccine-mediated ability of hosts to defend against viral infection in mice, and reduce local side effects at the inoculation site in pigs. D-Galacto-D-mannan can be used in the research of inflammatory and immune diseases, such as foot-and-mouth disease .

D-Galacto-D-mannan

Carob galactomannan

Biochemical Assay Reagents

D-Galacto-D-mannan (Carob galactomannan) is an orally active Dectin-2 agonist. D-Galacto-D-mannan exerts antioxidant activity against hydroxyl radical generation. D-Galacto-D-mannan activates Dectin-2 to trigger downstream signaling pathways, promote the expression of immunoregulatory molecules, coordinate innate and adaptive immune responses, and inhibit excessive inflammatory responses by upregulating the expression of Sirtuin 1. When used as a vaccine adjuvant, D-Galacto-D-mannan induces cellular and humoral immune responses, promotes IFNγ secretion, increases antibody levels and virus neutralization titers, and elevates the levels of immunoglobulin G and A. D-Galacto-D-mannan can serve as an adjuvant for foot-and-mouth disease vaccines, enhance the vaccine-mediated ability of hosts to defend against viral infection in mice, and reduce local side effects at the inoculation site in pigs. D-Galacto-D-mannan can be used in the research of inflammatory and immune diseases, such as foot-and-mouth disease .

Cat. No.	Product Name	Target	Research Area	Image

HY-P991733

BDC-3042	C-type Lectin-like Receptors (CTLRs)	Cancer
BDC-3042 is a Dectin-2 agonistic antibody. BDC-3042 can be used for the research of cancer .

Species:	Human (1) Mouse (1)
Tag:	His (1) Fc (1)
Source:	HEK293 (2)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P72967

	Dectin-2/CLEC6A Protein, Mouse (HEK293, His) C-type lectin domain family 6 member A; Dectin-2; Clec6a; Clec4n; Clecsf10	Mouse	HEK293
	Dectin-2/CLEC6A protein has carbohydrate binding and pattern recognition receptor activities, and is involved in the positive regulation of I-kappaB kinase/NF-kappaB signaling, immune response regulation, and fungal response. It is predicted to reside in membranes, particularly on the outside of the plasma membrane, and it is expressed in a variety of tissues, including bone marrow, embryos, lungs, spleen, and thymus. Dectin-2/CLEC6A Protein, Mouse (HEK293, His) is the recombinant mouse-derived Dectin-2/CLEC6A protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P74201

	Dectin-2/CLEC6A Protein, Human (HEK293, Fc) C-type lectin domain family 6 member A; Dectin-2; Clec6a; Clec4n; Clecsf10	Human	HEK293
	The Dectin-2/CLEC6A protein is a calcium-dependent lectin, a pattern recognition receptor in the innate immune system that specifically binds to Candida albicans α-mannan. Dectin-2/CLEC6A Protein, Human (HEK293, Fc) is the recombinant human-derived Dectin-2/CLEC6A protein, expressed by HEK293 , with N-hFc labeled tag.

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HY-RS02799

CLEC6A Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
CLEC6A Human Pre-designed siRNA Set A contains three designed siRNAs for CLEC6A gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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