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Delta6

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By Targets:	Biochemical Assay Reagents (1) Drug Derivative (1) Drug Intermediate (2) Endogenous Metabolite (1) Ferroptosis (1) Isotope-Labeled Compounds (1) Reference Standards (1) Stearoyl-CoA Desaturase (SCD) (3)
By Research Areas:	Inflammation/Immunology (3) Metabolic Disease (2)
Oligonucleotides:	Phospholipids (1)

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Biochemical Assay Reagents

Natural
Products

Isotope-Labeled Compounds

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-107410

SC-26196 4 Publications Verification	Stearoyl-CoA Desaturase (SCD)	Inflammation/Immunology
SC-26196 is a potent, orally active Delta6 desaturase (D6D, FADS2) inhibitor (IC₅₀=0.2 μM in a rat liver microsomal assay). Antiinflammatory properties .

HY-115319

CP-24879 hydrochloride 2 Publications Verification	Ferroptosis	Inflammation/Immunology
CP-24879 (hydrochloride) is a potent, selective and combined *delta5D/delta6D* inhibitor. CP-24879 (hydrochloride) can significantly reduce intracellular lipid accumulation and inflammatory injury in hepatocytes. CP-24879 (hydrochloride) exhibits superior antisteatotic and anti-inflammatory actions in fat-1 and ω-3-treated hepatocytes, and can be used for non-alcoholic steatohepatitis research .

HY-124346

T-3364366 1 Publications Verification	Stearoyl-CoA Desaturase (SCD)	Metabolic Disease
T-3364366 is a reversible, slow-binding, thienopyrimidinone delta-5 desaturase (D5D) inhibitor with IC₅₀s of 1.9 nM and 2.1 nM in HepG2 and RLN-10 cells, respectively. T-3364366 exhibits potent D5D (IC₅₀0=19 nM) inhibitory activity and excellent selectivity away from delta-6 desaturase (D6D, IC₅₀=6200 nM) and delta-9 desaturase (stearoyl-CoA desaturase, SCD,₅₀ >10000 nM) in the enzymatic activity assay .

HY-W102516

6-Dehydroprogesterone Δ6-Progesterone	Endogenous Metabolite	Others
6-Dehydroprogesterone (Δ6-Progesterone) is a steroid compound that can be found in Botryodiplodia theobromae. 6-Dehydroprogesterone is a metabolic product of Progesterone (HY-N0437) after a microbial dehydrogenation reaction. 6-Dehydroprogesterone can be used to study steroid metabolism pathways, microbial dehydrogenase activity, and the biotransformation of steroids .

HY-N7833

Heneicosapentaenoic acid	Biochemical Assay Reagents	Others
Heneicosapentaenoic Acid (HPA) is a 21:5 omega-3 fatty acid found in trace amounts in the green alga B. pennata and in fish oils. Its chemical composition is similar to eicosapentaenoic acid (EPA), except that a carbon is extended at the carboxy terminus, placing the first double bond at the δ6 position. HPA can be used to study the importance of double bond position in omega-3 fatty acids. It incorporates phospholipids and triacylglycerols in vivo with the same efficiency as EPA and docosahexaenoic acid, and exhibits a strong inhibitory effect on the synthesis of arachidonic acid from linoleic acid. HPA is a poor substrate for prostaglandin H synthase (PGHS) (cyclooxygenase) and 5-lipoxygenase, but retains the ability to rapidly inactivate PGHS.

HY-176098

Δ6-Testosterone enanthate	Drug Derivative	Others
Δ6-Testosterone enanthate is a synthetic anabolic steroid (AAS), being the Δ6-isomer of testosterone enanthate.

HY-W750938

Hydrocortisone impurity 4 Delta 6 hydrocortisone hemisuccinate	Drug Intermediate	Others
Hydrocortisone impurity 4 (Delta 6 hydrocortisone hemisuccinate) is an impurity of Hydrocortisone.

HY-107410R

SC-26196 (Standard)	Reference Standards Stearoyl-CoA Desaturase (SCD)	Inflammation/Immunology
SC-26196 (Standard) is the analytical standard of SC-26196 (HY-107410). This product is intended for research and analytical applications. SC-26196 is a potent, orally active Delta6 desaturase (D6D, FADS2) inhibitor (IC₅₀=0.2 μM in a rat liver microsomal assay). Antiinflammatory properties .

HY-Z8200

Fulvestrant impurity 5 Fulvestrant EP Impurity E; Δ6-Fulvestrant	Drug Intermediate	Others
Fulvestrant impurity 5 (Fulvestrant EP Impurity E) is an impurity of Fulvestrant.

HY-139429S

(−)-11-Hydroxy-Δ8-THC-d3 (−)-11-Hydoxy-Δ8-Tetahydocaabiol-d₃; (−)-tas-Δ8-THC-d₃; 7-hydoxy-Δ6-THC-d₃	Isotope-Labeled Compounds	Others
(?)-11-Hydroxy-Δ8-THC-d₃ ((?)-11-Hydoxy-Δ8-Tetahydocaabiol-d₃) is deuterium labeled (?)-11-hydroxy-Δ8-THC .

Cat. No.	Product Name	Type

HY-N7833

Heneicosapentaenoic acid	Biochemical Assay Reagents
Heneicosapentaenoic Acid (HPA) is a 21:5 omega-3 fatty acid found in trace amounts in the green alga B. pennata and in fish oils. Its chemical composition is similar to eicosapentaenoic acid (EPA), except that a carbon is extended at the carboxy terminus, placing the first double bond at the δ6 position. HPA can be used to study the importance of double bond position in omega-3 fatty acids. It incorporates phospholipids and triacylglycerols in vivo with the same efficiency as EPA and docosahexaenoic acid, and exhibits a strong inhibitory effect on the synthesis of arachidonic acid from linoleic acid. HPA is a poor substrate for prostaglandin H synthase (PGHS) (cyclooxygenase) and 5-lipoxygenase, but retains the ability to rapidly inactivate PGHS.

Heneicosapentaenoic acid

Biochemical Assay Reagents

Heneicosapentaenoic Acid (HPA) is a 21:5 omega-3 fatty acid found in trace amounts in the green alga B. pennata and in fish oils. Its chemical composition is similar to eicosapentaenoic acid (EPA), except that a carbon is extended at the carboxy terminus, placing the first double bond at the δ6 position. HPA can be used to study the importance of double bond position in omega-3 fatty acids. It incorporates phospholipids and triacylglycerols in vivo with the same efficiency as EPA and docosahexaenoic acid, and exhibits a strong inhibitory effect on the synthesis of arachidonic acid from linoleic acid. HPA is a poor substrate for prostaglandin H synthase (PGHS) (cyclooxygenase) and 5-lipoxygenase, but retains the ability to rapidly inactivate PGHS.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W102516

6-Dehydroprogesterone Δ6-Progesterone	Endogenous metabolite Steroids Source Classification	Endogenous Metabolite
6-Dehydroprogesterone (Δ6-Progesterone) is a steroid compound that can be found in Botryodiplodia theobromae. 6-Dehydroprogesterone is a metabolic product of Progesterone (HY-N0437) after a microbial dehydrogenation reaction. 6-Dehydroprogesterone can be used to study steroid metabolism pathways, microbial dehydrogenase activity, and the biotransformation of steroids .

Cat. No.	Product Name	Chemical Structure

HY-139429S

(−)-11-Hydroxy-Δ8-THC-d3
(?)-11-Hydroxy-Δ8-THC-d₃ ((?)-11-Hydoxy-Δ8-Tetahydocaabiol-d₃) is deuterium labeled (?)-11-hydroxy-Δ8-THC .

18:1 (Δ6-Cis) PC PC(18:1(6Z)/18:1(6Z))		Phospholipids
18:1 (Δ6-Cis) PC is a phospholipid.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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Delta6

Inhibitors & Agonists

Biochemical Assay Reagents

NaturalProducts

Isotope-Labeled Compounds

Oligonucleotides

Natural
Products