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Results for "

Dopamine transporter (DAT)

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Dopamine Receptor (6) Dopamine Transporter (28) 5-HT Receptor (8) Adenylate Cyclase (3) Adrenergic Receptor (2) Amyloid-β (1) Autophagy (1) Biochemical Assay Reagents (1) CDK (2) Drug Derivative (1) Drug Metabolite (1) Histamine Receptor (1) Histone Methyltransferase (2) Isotope-Labeled Compounds (3) mAChR (1) Monoamine Transporter (5) Reference Standards (6) Serotonin Transporter (14) Sigma Receptor (5) Sodium Channel (1) Trk Receptor (1)
By Research Areas:	Cancer (3) Inflammation/Immunology (1) Neurological Disease (52)

By Targets:

Dopamine Receptor (6)

Dopamine Transporter (28)

5-HT Receptor (8)

Adenylate Cyclase (3)

Adrenergic Receptor (2)

Amyloid-β (1)

Autophagy (1)

Biochemical Assay Reagents (1)

CDK (2)

Drug Derivative (1)

Drug Metabolite (1)

Histamine Receptor (1)

Histone Methyltransferase (2)

Isotope-Labeled Compounds (3)

mAChR (1)

Monoamine Transporter (5)

Reference Standards (6)

Serotonin Transporter (14)

Sigma Receptor (5)

Sodium Channel (1)

Trk Receptor (1)

By Research Areas:

Cancer (3)

Inflammation/Immunology (1)

Neurological Disease (52)

Inhibitors & Agonists

Biochemical Assay Reagents

Natural
Products

Isotope-Labeled Compounds

Antibodies

Targets Recommended: Dopamine Transporter Dopamine Receptor Dopamine β-hydroxylase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-13217

Vanoxerine dihydrochloride 5+ Cited Publications GBR-12909 dihydrochloride; I893 dihydrochloride	Dopamine Transporter	Neurological Disease
Vanoxerine dihydrochloride (GBR-12909 dihydrochloride) is a competitive, potent, and highly selective dopamine reuptake inhibitor (K_i=1 nM). Vanoxerine dihydrochloride (GBR-12909 dihydrochloride) binds to the target site on the dopamine transporter (DAT) .

HY-14258

Escitalopram 10+ Cited Publications (S)-Citalopram; (S)-(+)-Citalopram	Serotonin Transporter	Neurological Disease
Escitalopram ((S)-Citalopram), the S-enantiomer of racemic Citalopram, is a selective serotonin reuptake inhibitor (SSRI) with a K_i of 0.89 nM. Escitalopram has ∼30 fold higher binding affinity than its R(-)-enantiomer and shows selectivity over both dopamine transporter (DAT) and norepinephrine transporter (NET). Escitalopram is an antidepressant for the research of major depression .

HY-14258A

Escitalopram oxalate Maximum Cited Publications 11 Publications Verification (S)-Citalopram oxalate; (S)-(+)-Citalopram oxalate	Serotonin Transporter	Neurological Disease Cancer
Escitalopram ((S)-Citalopram) oxalate, the S-enantiomer of racemic Citalopram, is a selective serotonin reuptake inhibitor (SSRI) with a K_i of 0.89 nM. Escitalopram oxalate has ∼30 fold higher binding affinity than its R(-)-enantiomer and shows selectivity over both dopamine transporter (DAT) and norepinephrine transporter (NET). Escitalopram oxalate is an antidepressant for the research of major depression .

HY-Y1191

EEDQ EEDQ	Biochemical Assay Reagents 5-HT Receptor Dopamine Transporter	Neurological Disease
EEDQ is a carboxylate activator and irreversible antagonist of 5HT2c receptors. EEDQ reduces [ ³H]β-CIT binding to the dopamine transporter (DAT) in rat caudate-putamen (CPu) homogenates (IC₅₀ = 78.3 μM). EEDQ inhibits contralateral rotation behavior .

HY-135608

BD-1008	Sigma Receptor	Neurological Disease
BD-1008 is a nonselective σ receptor antagonist with K_is against σ1 receptor and σ2 receptor of 2 nM and 8 nM. The BD-1008 has an extremely low affinity for the D2 receptor (K_i = 1112 nM) and dopamine transporter (DAT) (K_i > 10,000 nM). BD-1008 significantly antagonizes dopamine release in the shell region of the nucleus accumbens via the σ₂ receptor. BD-1008 blocks the self-administration behavior of σ agonists.BD-1008 can be used for the study of addiction therapy that target the σ receptor .

HY-101315

AHN 1-055 hydrochloride 3 Publications Verification 3α-Bis-(4-fluorophenyl) Methoxytropane hydrochloride	Dopamine Transporter	Neurological Disease
AHN 1-055 hydrochloride is a dopamine uptake inhibitor that can cross the blood-brain barrier, with an IC₅₀ of 71 nM. AHN 1-055 hydrochloride binds with high affinity to the **dopamine transporter (DAT)** .

HY-161724

TFEB activator 2	Amyloid-β Dopamine Transporter CDK Autophagy	Neurological Disease
TFEB activator 2 is an orally active compound that can cross the blood-brain barrier. TFEB activator 2 can bind to the dopamine transporter (DAT). TFEB activator 2 promotes TFEB nuclear translocation and lysosome biogenesis by targeting the *DAT-CDK9-TFEB* pathway. TFEB activator 2 has neuroprotective activity and can be used in the research of Alzheimer's disease and other diseases .

HY-103430A

SKF-83566 2 Publications Verification	Dopamine Receptor 5-HT Receptor Adenylate Cyclase	Neurological Disease
SKF-83566 is a potent, blood-brain permeable and orally active *D1-like dopamine* receptor (D1DR) antagonist and a weaker competitive antagonist at the vascular 5-HT₂ receptor (K_i*=11 nM) . SKF-83566 is a competitive DAT* (dopamine transporter) inhibitor with an IC₅₀ of 5.7 μM . SKF-83566 also shows selective inhibition for adenylyl cyclase 2 (AC2) over AC₁ and AC₅ in the isolated rabbit thoracic aorta . SKF-83566 can be used for research of parkinson’s disease and nicotine craving alleviation .

HY-111928

5,7-Dimethoxyluteolin	Dopamine Transporter	Neurological Disease
5,7-Dimethoxyluteolin, a 5,7-dimethylluteolin derivative, is a **dopamine transporter (DAT) activator with an EC₅₀** of 3.417 μM .

HY-13217A

Vanoxerine 5+ Cited Publications GBR 12909; I893	Dopamine Transporter	Neurological Disease
Vanoxerine (GBR-12909) is a competitive, potent, and highly selective dopamine reuptake inhibitor (K_i=1 nM). Vanoxerine (GBR-12909) binds to the target site on the dopamine transporter (DAT) .

HY-161723

LH2-051	Dopamine Transporter CDK	Neurological Disease
LH2-051, a lysosome-enhancing compound (LYEC), is a brain-penetrant **dopamine transporter** (DAT) inhibitor (K_i: 0.95 μM). LH2-051 inhibits *DAT*-mediated dopamine uptake with an IC₅₀ of 3.0 μM. LH2-051 promotes nuclear translocation of TFEB and lysosome biogenesis. LH2-051 improves the memory of amyloid precursor protein (APP)/Presenilin 1 (PS1) mice. LH2-051 can be used for the study of Alzheimer’s disease .

HY-14258AR

Escitalopram oxalate (Standard) (S)-Citalopram oxalate (Standard); (S)-(+)-Citalopram oxalate (Standard)	Reference Standards Serotonin Transporter	Neurological Disease Cancer
Escitalopram (oxalate) (Standard) is the analytical standard of Escitalopram (oxalate). This product is intended for research and analytical applications. Escitalopram ((S)-Citalopram) oxalate, the S-enantiomer of racemic Citalopram, is a selective serotonin reuptake inhibitor (SSRI) with a K_i of 0.89 nM. Escitalopram oxalate has ∼30 fold higher binding affinity than its R(-)-enantiomer and shows selectivity over both dopamine transporter (DAT) and norepinephrine transporter (NET). Escitalopram oxalate is an antidepressant for the research of major depression .

HY-N7506

13-Hydroxyisobakuchiol Delta3,2-Hydroxylbakuchiol	Monoamine Transporter Dopamine Transporter	Neurological Disease
13-Hydroxyisobakuchiol (Delta3,2-Hydroxylbakuchiol), an analog of Bakuchiol (HY-N0235) that can be isolated from Psoralea corylifolia (L.), is a potent selective monoamine transporter inhibitor. 13-Hydroxyisobakuchiol is more selective for the dopamine transporter (DAT) (IC₅₀ = 0.58 μM) and norepinephrine transporter (NET) (IC₅₀ = 0.69 μM) than for the serotonin transporter (SERT) (IC₅₀ = 312.02 μM). 13-Hydroxyisobakuchiol increases the activity of intact mice and improves the decreased activity of reserpinized mice in vivo. 13-Hydroxyisobakuchiol can be used for the research of disorders such as Parkinson's disease and depression .

HY-158013A

JJC8-088 dioxalate	Dopamine Transporter	Neurological Disease
JJC8-088 dioxalate is the dioxalate salt form of JJC8-088 (HY-158013). JJC8-088 dioxalate is a derivative of modafinil. JJC8-088 dioxalate is an inhibitor for **dopamine transporter** (DAT). JJC8-088 dioxalate exhibits behavioral characteristics similar to cocaine in rat models, and can be to study psychostimulant use disorders .

HY-17590

Radafaxine hydrochloride 1 Publications Verification (S,S)-Hydroxybupropion hydrochloride; GW-353162A; BW-306U	Monoamine Transporter	Neurological Disease
Radafaxine hydrochloride (GW-353162A) is a **DAT (dopamine transporter)** and NET(norepinephrine transporter) transporters inhibitor, and nAChR family modulator.

HY-14840A

(R)-Phenylpiracetam MRZ 9547	Dopamine Transporter	Neurological Disease Inflammation/Immunology
(R)-Phenylpiracetam (MRZ 9547) is a dopamine transporter (DAT) inhibitor (K_i: 14.8 μM; IC₅₀: 65.5 μM). (R)-Phenylpiracetam can be used for the research of the neurological or neuropsychiatric disorders .

HY-163384

(S)-CE-123	Dopamine Transporter	Neurological Disease
(S)-CE-123 is a potent, selective, and novel atypical **dopamine transporter (DAT) inhibitor with an EC₅₀** of 2.76 μM in uptake inhibition assays conducted in HEK293 cells stably expressing human isoforms of DAT. (S)-CE-123, a Modafinil analogue, is able to penetrate the blood–brain barrier. (S)-CE-123 improves cognitive and motivational processes in experimental animals .

HY-117902

SRI-31142	Dopamine Transporter	Neurological Disease
SRI-31142 is a putative, brain-penetrant allosteric inhibitor of the dopamine transporter (DAT). In behavioral studies using intracranial self-stimulation (ICSS), SRI-31142 did not produce the abuse-related effects seen with cocaine and GBR-12935, but instead reduced ICSS responses and dopamine levels in the nucleus accumbens (NAc) at effective doses. SRI-31142 also blocked cocaine-induced increases in ICSS and NAc dopamine .

HY-135096

Amitriptyline-d3 hydrochloride	Serotonin Transporter 5-HT Receptor Histamine Receptor mAChR Adrenergic Receptor Sodium Channel Trk Receptor	Neurological Disease
Amitriptyline-d3 hydrochloride is the deuterium labeled Amitriptyline (hydrochloride). Amitriptyline hydrochloride is an inhibitor of *serotonin reuptake transporter* (SERT) and noradrenaline reuptake transporter (NET), with K_is of 3.45 nM and 13.3 nM for human SERT and NET, respectively. Amitriptyline hydrochloride also weakly binds to dopamine reuptake transporter (DAT) with a K_i of 2.58 μM. Amitriptyline hydrochloride also inhibits adrenergic, muscarinic, histamine and 5-HT receptors. Amitriptyline hydrochloride is a TrkA and TrkB** receptors agonist with potent neurotrophic activity. Amitriptyline hydrochloride has antidepressant activity .

HY-158013

JJC8-088	Dopamine Transporter	Neurological Disease
JJC8-088, a Modafinil-derived ligand, is a **dopamine transporter (DAT) inhibitor with a K_i** of 2.53 nM. JJC8-088 dioxalate can be to study psychostimulant use disorders .

HY-14258AS

Escitalopram-d6 oxalate	Serotonin Transporter	Neurological Disease
Escitalopram-d₆ (oxalate) is the deuterium labeled Escitalopram oxalate. Escitalopram ((S)-Citalopram) oxalate, the S-enantiomer of racemic Citalopram, is a selective serotonin reuptake inhibitor (SSRI) with a K_i of 0.89 nM. Escitalopram oxalate has ～30 fold higher binding affinity than its R(-)-enantiomer and shows selectivity over both dopamine transporter (DAT) and norepinephrine transporter (NET). Escitalopram oxalate is an antidepressant for the research of major depression .

HY-158014

JJC8-089	Dopamine Transporter	Neurological Disease
JJC8-089 is a dopamine transporter (DAT) inhibitor that may improve motivational dysfunction and increase effortful behavior in goal-directed activities. JJC8-089 significantly reversed the low-effort effects induced by the VMAT-2 inhibitor Tetrabenazine (HY-B0590) in rats and increased the choice of high-effort fixed-ratio 5-bar presses versus food intake. .

HY-172421

Cendifensine	Monoamine Transporter Serotonin Transporter Dopamine Transporter	Neurological Disease
Cendifensine is the inhibitor for monoamine reuptake that inhibits the serotonin transporter (SERT), norepinephrine transporter (NET), and dopamine transporter (DAT) .

HY-B0457S

Clomipramine-d3 hydrochloride Chlorimipramine-d3 hydrochloride; G-34586-d3 hydrochloride; NSC-169865-d3 hydrochloride	Serotonin Transporter Dopamine Receptor	Neurological Disease
Clomipramine-d₃ (hydrochloride) is a deuterium labeled Clomipramine hydrochloride. Clomipramine hydrochloride is a serotonin transporter (SERT), norepinephrine transporter (NET) dopamine transporter (DAT) blocker with K_i of 0.14, 54 and 3 nM, respectively .

HY-B0457AS

Clomipramine-d3 Chlorimipramine-d₃; G-34586-d₃; NSC-169865-d₃	Isotope-Labeled Compounds Serotonin Transporter Dopamine Receptor	Neurological Disease
Clomipramine-d₃ is the deuterium labeled Clomipramine. Clomipramine is a serotonin transporter (SERT), norepinephrine transporter (NET) dopamine transporter (DAT) blocker with K_i of 0.14, 54 and 3 nM, respectively .

HY-107128

Ampreloxetine hydrochloride TD-9855 hydrochloride	Serotonin Transporter	Neurological Disease
Ampreloxetine (TD-9855) hydrochloride is an orally active and CNS-penetrant inhibitor of Norepinephrine transporter (NET) and Serotonin 5-HT uptake transporter (SERT), but not **Dopamine transporter** (DAT). Ampreloxetine hydrochloride binds norepinephrine transporters (NET) and serotonin transporters (SERT) with EC₅₀ values of 11.7 ng/mL and 50.8 ng/mL, respectively, in plasma .

HY-107055

RTI 336	Dopamine Transporter	Neurological Disease
RTI 336 is a phenyltropane analog, as well as a potent and selective **dopamine transporter (DAT)** inhibitor. RTI 336 inhibits addictive agent induced locomotor activity and self-administration in Lewis rats. RTI 336 exhibits inhibitory effects depending on inherent NAc DAT levels .

HY-14258AS1

Escitalopram-d4 oxalate (S)-Citalopram-d4 oxalate; (S)-(+)-Citalopram-d4 oxalate	Isotope-Labeled Compounds Serotonin Transporter	Neurological Disease
Escitalopram-d₄ (oxalate) is deuterium labeled Escitalopram (oxalate). Escitalopram ((S)-Citalopram) oxalate, the S-enantiomer of racemic Citalopram, is a selective serotonin reuptake inhibitor (SSRI) with a K_i of 0.89 nM. Escitalopram oxalate has ～30 fold higher binding affinity than its R(-)-enantiomer and shows selectivity over both dopamine transporter (DAT) and norepinephrine transporter (NET). Escitalopram oxalate is an antidepressant for the research of major depression .

HY-18332B

DOV-102,677	Dopamine Transporter Adrenergic Receptor 5-HT Receptor	Neurological Disease
DOV-102,677 is an orally sctive triple monoamine neurotransmitter reuptake inhibitor that simultaneously inhibits the dopamine (DAT) (IC₅₀ = 129 nM; K_i = 222 nM), norepinephrine (NET) (IC₅₀ = 103 nM; K_i = 1030 nM), and serotonin (SERT) (IC₅₀ = 133 nM; K_i = 740 nM) transporters. DOV-102,677 demonstrated significant antidepressant-like activity and sensory-motor gating regulatory effects in mouse experiments. DOV-102,677 can be used for research on depression .

HY-100966

BD-1008 dihydrobromide	Sigma Receptor	Neurological Disease
BD-1008 dihydrobromide is a nonselective σ receptor antagonist with K_is against σ1 receptor and σ2 receptor of 2 nM and 8 nM. The BD-1008 dihydrobromide has an extremely low affinity for the D2 receptor (K_i = 1112 nM) and dopamine transporter (DAT) (K_i > 10,000 nM). BD-1008 dihydrobromide significantly antagonizes dopamine release in the shell region of the nucleus accumbens via the σ₂ receptor. BD-1008 dihydrobromide blocks the self-administration behavior of σ agonists.BD-1008 dihydrobromide can be used for the study of addiction therapy that target the σ receptor .

HY-163155

RDS03-94	Dopamine Transporter	Neurological Disease
RDS03-94 is a **dopamine transporter (DAT)** inhibitor. RDS03-94 reduces hERG/DAT ratio .

HY-163156

JJC12-009	Dopamine Transporter	Neurological Disease
JJC12-009 is a dopamine transporter (DAT) inhibitor, with a K_i of 5.45 nM .

HY-126158

SRI-29574	Dopamine Transporter Serotonin Transporter	Neurological Disease
SRI-29574 is an allosteric modulator of the dopamine transporter (DAT). SRI-29574 partially inhibits the uptake of the *DAT* (IC₅₀=2.3 nM) and also partially inhibits the uptake of the serotonin transporter (SERT) and norepinephrine transporter (NET). SRI-29574 may serve as a useful probe to study the function and regulatory mechanisms of DAT .

HY-172029

3,4-Methylenedioxy pyrovalerone metabolite 2 hydrochloride	Monoamine Transporter	Neurological Disease
3,4-Methylenedioxy pyrovalerone metabolite 2 hydrochloride is an analog of Pyrovalerone. Pyrovalerone inhibits the dopamine transporter (DAT)，serotonin transporter (SERT)，and the norepinephrine transporter (NET) .

HY-137107

Radafaxine (S,S)-Hydroxybupropion; GW-353162A free base; BW-306U free base	Monoamine Transporter Drug Metabolite	Neurological Disease
Radafaxine ((S,S)-Hydroxybupropion) is an antidepressant. Radafaxine blocks **dopamine transporters (DAT)**. Radafaxine is an active metabolite of Bupropion .

HY-163154

JJC8-091	Dopamine Transporter	Neurological Disease
JJC8-091 is a potent **dopamine transporter (DAT) inhibitor with K_i** values of 230, 97800 nM for DAT, SERT, respectively. JJC8-091 has the potential for the research of psychostimulant use disorders (PSUD) .

HY-161913

AC-4-248	Dopamine Transporter	Neurological Disease
AC-4-248 is an atypical non-competitive **dopamine transporter (DAT)** inhibitor and reduces the potency of cocaine to inhibit DAT. AC-4-248 is a non-selective inhibitor of SLC6 transporters with IC₅₀ values for hDAT, hSERT, and hNET of 45.5 μM, 96.2 μM, and 250 μM, respectively .

HY-173475

CM699	Sigma Receptor Dopamine Transporter	Neurological Disease
CM699 is a potent **Dopamine Transporter (DAT) and Sigma-receptor (σR) dual inhibitor with IC₅₀**s of 311 and 14.1 nM, respectively .

HY-163138

DAT-IN-1	Dopamine Transporter	Neurological Disease
DAT-IN-1 (Coumpound 12b) is an atypical DAT inhibitor with a K_i of 8.37 nM. DAT-IN-1 can be used in the study of psychostimulant use disorder (PSUD) .

HY-13217R

Vanoxerine dihydrochloride (Standard) GBR-12909 dihydrochloride (Standard); I893 dihydrochloride (Standard)	Dopamine Transporter Reference Standards	Neurological Disease
Vanoxerine (dihydrochloride) (Standard) is the analytical standard of Vanoxerine (dihydrochloride). This product is intended for research and analytical applications. Vanoxerine dihydrochloride (GBR-12909 dihydrochloride) is a competitive, potent, and highly selective dopamine reuptake inhibitor (Ki=1 nM). Vanoxerine dihydrochloride (GBR-12909 dihydrochloride) binds to the target site on the dopamine transporter (DAT) .

HY-117542

D595	Histone Methyltransferase	Neurological Disease
D595 is a phenylethylamine calcium channel blocker with potent negative inotropic activity. D595 has shown significant efficacy in its corresponding pharmacological studies, especially in inhibiting the uptake of monoamine neurotransmitters. D595 has high affinity in binding to the dopamine transporter (DAT), serotonin transporter (SERT), and norepinephrine transporter (NET). Structural adjustments of D595, especially changes in the hydroxyl stereochemistry, significantly affect its interaction with the transporters, showing a specific preference for stereoisomers .

HY-174282

RDS-04-010	Dopamine Transporter	Neurological Disease
RDS-04-010 is an atypical dopamine transporter (DAT) inhibitor. RDS-04-010 has the effect of inhibiting cocaine intake and seeking behavior. RDS-04-010 exerts its modulatory effect mainly by binding to the inward conformation of DAT, thereby reducing the reinforcing effect of cocaine. RDS-04-010 can be used in the study of cocaine use disorder (CUD) .

HY-116062A

JNJ-7925476	Histone Methyltransferase	Neurological Disease
JNJ-7925476 is a triple reuptake inhibitor that selectively and potently inhibits the activity of the serotonin transporter (SERT), norepinephrine transporter (NET), and dopamine transporter (DAT). JNJ-7925476 is rapidly absorbed into the blood and its concentration in the brain is 7-fold higher than that in plasma. The occupancy ED(50) values of JNJ-7925476 for SERT, NET, and DAT in the rat brain are 0.18, 0.09, and 2.4 mg/kg, respectively. JNJ-7925476 rapidly induces a significant increase in the levels of extracellular serotonin, dopamine, and norepinephrine in the rat cerebral cortex in a dose-dependent manner. JNJ-7925476 exhibits potent antidepressant-like activity in the mouse tail suspension test. These results suggest that JNJ-7925476 has in vivo efficacy in biochemical and behavioral models of depression .

HY-14258R

Escitalopram (Standard) (S)-Citalopram (Standard); (S)-(+)-Citalopram (Standard)	Serotonin Transporter Reference Standards	Neurological Disease Cancer
Escitalopram (Standard) is the analytical standard of Escitalopram. This product is intended for research and analytical applications. Escitalopram ((S)-Citalopram), the S-enantiomer of racemic Citalopram, is a selective serotonin reuptake inhibitor (SSRI) with a Ki of 0.89 nM. Escitalopram has ～30 fold higher binding affinity than its R(-)-enantiomer and shows selectivity over both dopamine transporter (DAT) and norepinephrine transporter (NET). Escitalopram is an antidepressant for the research of major depression .

HY-108513

σ1 Receptor antagonist 4	Sigma Receptor	Neurological Disease
σ1 Receptor antagonist 4 (compound TC1) is a selective sigma1 (σ1) receptor antagonist with a K_i of 10 nM. σ1 Receptor antagonist 4 is weakly active at σ2 receptor (K_i of 370 nM) and has no activity at dopamine (DAT), serotonin (SERT), and norepinephrine (NET) transporters .

HY-103430

SKF-83566 hydrobromide	Dopamine Receptor 5-HT Receptor Adenylate Cyclase	Neurological Disease
SKF-83566 hydrobromide is a potent, blood-brain permeable and orally active *D1-like dopamine* receptor (D1DR) antagonist and a weaker competitive antagonist at the vascular 5-HT₂ receptor (K_i*=11 nM) . SKF-83566 is a competitive DAT* (dopamine transporter) inhibitor with an IC₅₀ of 5.7 μM . SKF-83566 also shows selective inhibition for adenylyl cyclase 2 (AC₂) over AC₁ and AC₅ in the isolated rabbit thoracic aorta . SKF-83566 can be used for the research of parkinson’s disease and nicotine craving alleviation .

HY-100966S

BD-1008-d5 dihydrobromide	Isotope-Labeled Compounds Sigma Receptor	Neurological Disease
BD-1008-d₅ dihydrobromide is the deuterium labeled BD-1008 dihydrobromide (HY-100966). BD-1008 dihydrobromide is a nonselective σ receptor antagonist with K_is against σ1 receptor and σ2 receptor of 2 nM and 8 nM. The BD-1008 dihydrobromide has an extremely low affinity for the D2 receptor (K_i = 1112 nM) and dopamine transporter (DAT) (K_i > 10,000 nM). BD-1008 dihydrobromide significantly antagonizes dopamine release in the shell region of the nucleus accumbens via the σ₂ receptor. BD-1008 dihydrobromide blocks the self-administration behavior of σ agonists.BD-1008 dihydrobromide can be used for the study of addiction therapy that target the σ receptor .

HY-172763

EDMA hydrochloride	Drug Derivative Serotonin Transporter Dopamine Transporter 5-HT Receptor	Neurological Disease
EDMA hydrochloride is a derivative of MDMA. EDMA hydrochloride is a substrate for multiple neurotransmitter transporters, including serotonin transporter (SERT), dopamine transporter (DAT), and norepinephrine transporter (NET). EDMA hydrochloride has 5-HT releasing activity at SERT (EC₅₀ = 117 nM) and MPP ⁺ releasing activity at DAT (EC₅₀ = 597 nM) and NET (EC₅₀ = 325 nM) .

HY-124186

LR1143	Dopamine Receptor 5-HT Receptor	Neurological Disease
LR1143 is a dopamine transporter (DAT) and 5-HT uptake inhibitor, with IC₅₀ values of 3.4 nM and 112 nM in rats, respectively. LR1143 binds to *DAT* labeled with the dopamine reuptake inhibitor GBR 12935 (HY-12242A), with an IC₅₀ of 4.4 nM. LR1143 shows lower selectivity for *DAT* than for serotonin reuptake sites. LR1143 can be used in studies related to cocaine abuse .

HY-101315R

AHN 1-055 hydrochloride (Standard) 3α-Bis-(4-fluorophenyl) Methoxytropane hydrochloride (Standard)	Dopamine Transporter Reference Standards	Neurological Disease
AHN 1-055 (hydrochloride) (Standard) is the analytical standard of AHN 1-055 (hydrochloride) (HY-101315). This product is intended for research and analytical applications. AHN 1-055 hydrochloride is a dopamine uptake inhibitor, with an IC50 of 71 nM. AHN 1-055 hydrochloride binds with high affinity to the dopamine transporter (DAT) .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-14258

Escitalopram 10+ Cited Publications (S)-Citalopram; (S)-(+)-Citalopram	Natural Products Endogenous metabolite Source Classification	Serotonin Transporter
Escitalopram ((S)-Citalopram), the S-enantiomer of racemic Citalopram, is a selective serotonin reuptake inhibitor (SSRI) with a K_i of 0.89 nM. Escitalopram has ∼30 fold higher binding affinity than its R(-)-enantiomer and shows selectivity over both dopamine transporter (DAT) and norepinephrine transporter (NET). Escitalopram is an antidepressant for the research of major depression .

HY-111928

5,7-Dimethoxyluteolin	Flavonoids Flavones Phenols Polyphenols Plants Bauhinia purpurea L. Compositae Source Classification	Dopamine Transporter
5,7-Dimethoxyluteolin, a 5,7-dimethylluteolin derivative, is a **dopamine transporter (DAT) activator with an EC₅₀** of 3.417 μM .

HY-N7506

13-Hydroxyisobakuchiol Delta3,2-Hydroxylbakuchiol	Structural Classification Monophenols Leguminosae Phenols Psoralea corylifolia L. Plants Source Classification	Monoamine Transporter Dopamine Transporter
13-Hydroxyisobakuchiol (Delta3,2-Hydroxylbakuchiol), an analog of Bakuchiol (HY-N0235) that can be isolated from Psoralea corylifolia (L.), is a potent selective monoamine transporter inhibitor. 13-Hydroxyisobakuchiol is more selective for the dopamine transporter (DAT) (IC₅₀ = 0.58 μM) and norepinephrine transporter (NET) (IC₅₀ = 0.69 μM) than for the serotonin transporter (SERT) (IC₅₀ = 312.02 μM). 13-Hydroxyisobakuchiol increases the activity of intact mice and improves the decreased activity of reserpinized mice in vivo. 13-Hydroxyisobakuchiol can be used for the research of disorders such as Parkinson's disease and depression .

HY-14258R

Escitalopram (Standard) (S)-Citalopram (Standard); (S)-(+)-Citalopram (Standard)	Structural Classification Natural Products Endogenous metabolite Source Classification	Serotonin Transporter Reference Standards
Escitalopram (Standard) is the analytical standard of Escitalopram. This product is intended for research and analytical applications. Escitalopram ((S)-Citalopram), the S-enantiomer of racemic Citalopram, is a selective serotonin reuptake inhibitor (SSRI) with a Ki of 0.89 nM. Escitalopram has ～30 fold higher binding affinity than its R(-)-enantiomer and shows selectivity over both dopamine transporter (DAT) and norepinephrine transporter (NET). Escitalopram is an antidepressant for the research of major depression .

Cat. No.	Product Name	Chemical Structure

HY-14258AS

Escitalopram-d6 oxalate

Escitalopram-d₆ (oxalate) is the deuterium labeled Escitalopram oxalate. Escitalopram ((S)-Citalopram) oxalate, the S-enantiomer of racemic Citalopram, is a selective serotonin reuptake inhibitor (SSRI) with a K_i of 0.89 nM. Escitalopram oxalate has ～30 fold higher binding affinity than its R(-)-enantiomer and shows selectivity over both dopamine transporter (DAT) and norepinephrine transporter (NET). Escitalopram oxalate is an antidepressant for the research of major depression .

HY-B0457S

Clomipramine-d3 hydrochloride
Clomipramine-d₃ (hydrochloride) is a deuterium labeled Clomipramine hydrochloride. Clomipramine hydrochloride is a serotonin transporter (SERT), norepinephrine transporter (NET) dopamine transporter (DAT) blocker with K_i of 0.14, 54 and 3 nM, respectively .

HY-B0457AS

Clomipramine-d3
Clomipramine-d₃ is the deuterium labeled Clomipramine. Clomipramine is a serotonin transporter (SERT), norepinephrine transporter (NET) dopamine transporter (DAT) blocker with K_i of 0.14, 54 and 3 nM, respectively .

HY-14258AS1

Escitalopram-d4 oxalate

Escitalopram-d₄ (oxalate) is deuterium labeled Escitalopram (oxalate). Escitalopram ((S)-Citalopram) oxalate, the S-enantiomer of racemic Citalopram, is a selective serotonin reuptake inhibitor (SSRI) with a K_i of 0.89 nM. Escitalopram oxalate has ～30 fold higher binding affinity than its R(-)-enantiomer and shows selectivity over both dopamine transporter (DAT) and norepinephrine transporter (NET). Escitalopram oxalate is an antidepressant for the research of major depression .

HY-100966S

BD-1008-d5 dihydrobromide

BD-1008-d₅ dihydrobromide is the deuterium labeled BD-1008 dihydrobromide (HY-100966). BD-1008 dihydrobromide is a nonselective σ receptor antagonist with K_is against σ1 receptor and σ2 receptor of 2 nM and 8 nM. The BD-1008 dihydrobromide has an extremely low affinity for the D2 receptor (K_i = 1112 nM) and dopamine transporter (DAT) (K_i > 10,000 nM). BD-1008 dihydrobromide significantly antagonizes dopamine release in the shell region of the nucleus accumbens via the σ₂ receptor. BD-1008 dihydrobromide blocks the self-administration behavior of σ agonists.BD-1008 dihydrobromide can be used for the study of addiction therapy that target the σ receptor .

Host:	Rat (1) Rabbit (2)
Reactivity:	Human (1) Rat (3) Mouse (3)
Application:	IHC-P (3) ICC/IF (1) WB (3) IHC-F (3) ELISA (1)
Isotype:	IgG (2)
Conjugation:	Non-conjugated (3)
Clonality:	Polyclonal (1) Monoclonal (2) Recombinant (2)
Modification:	Unmodified (3)

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HY-P86855

	Dopamine Transporter Antibody (YA6548) DA transporter antibody; DAT 1 antibody; DAT antibody; DAT1 antibody; Dopamine transporter 1 antibody; Dopamine transporter antibody; PKDYS antibody; SC6A3_HUMAN antibody; SLC6A3 antibody; Sodium dependent Dopamine transporter antibody; DA transporter antibody; DAT 1 antibody; DAT antibody; DAT1 antibody; Dopamine transporter 1 antibody; Dopamine transporter antibody; PKDYS antibody; SC6A3_HUMAN antibody; SLC6A3 antibody; Sodium dependent Dopamine transporter antibody; Sodium-dependent Dopamine transporter antibody; Solute carrier family 6 (neurotransmitter transporter Dopamine), member 3 antibody; Solute carrier family 6 (neurotransmitter transporter), member 3 antibody; Solute carrier family 6 member 3 antibody; Variable number tandem repeat (VNTR) antibody;	IHC-F, IHC-P, WB	Mouse, Rat
	Dopamine Transporter Antibody (YA6548) is a Rat -derived and non-conjugated monoclonal antibody, targeting to Dopamine Transporter.

HY-P86856

	Dopamine Transporter Antibody (YA6549) DA transporter antibody; DAT 1 antibody; DAT antibody; DAT1 antibody; Dopamine transporter 1 antibody; Dopamine transporter antibody; PKDYS antibody; SC6A3_HUMAN antibody; SLC6A3 antibody; Sodium dependent Dopamine transporter antibody; DA transporter antibody; DAT 1 antibody; DAT antibody; DAT1 antibody; Dopamine transporter 1 antibody; Dopamine transporter antibody; PKDYS antibody; SC6A3_HUMAN antibody; SLC6A3 antibody; Sodium dependent Dopamine transporter antibody; Sodium-dependent Dopamine transporter antibody; Solute carrier family 6 (neurotransmitter transporter Dopamine), member 3 antibody; Solute carrier family 6 (neurotransmitter transporter), member 3 antibody; Solute carrier family 6 member 3 antibody; Variable number tandem repeat (VNTR) antibody;	WB, IHC-F, IHC-P	Mouse, Rat
	Dopamine Transporter Antibody (YA6549) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Dopamine Transporter.

HY-P81165

	Dopamine Transporter Antibody DA transporter; DAT 1; DAT; DAT1; SC6A3_HUMAN; SLC6A3; Sodium dependent Dopamine transporter; Sodium-dependent Dopamine transporter; Solute carrier family 6 (neurotransmitter transporter Dopamine), member 3; Solute carrier family 6 member 3; Variable number tandem repeat (VNTR); Dopamine transporter; ADAT 1; Adenosine deaminase tRNA specific 1; HADAT1; tRNA specific adenosine deaminase 1.	WB, ELISA, IHC-P, IHC-F, ICC/IF	Human, Mouse, Rat
	Dopamine Transporter Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to Dopamine Transporter.

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