JJC8-088 dioxalate
Based on 1 Customer Validation
JJC8-088 dioxalate is the dioxalate salt form of JJC8-088 (HY-158013). JJC8-088 dioxalate is a derivative of modafinil. JJC8-088 dioxalate is an inhibitor for dopamine transporter (DAT). JJC8-088 dioxalate exhibits behavioral characteristics similar to cocaine in rat models, and can be to study psychostimulant use disorders.
For research use only. We do not sell to patients.
- Purity: 99.73%
- CAS No.: 2068692-71-5
- Formula: C32H36F2N2O10S
- Molecular Weight:678.70
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
JJC8-088 (0-30 mg/kg, i.p., 30 min prior to testing) dioxalate can cause a large and rapid increase in extracellular Dopamine (DA) (HY-B0451) levels in rats with history of toxic molecules self-administration[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:METH addict male Wistar rats (6-8 weeks old; weighing 200-250 g)[1]
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Dosage:3 mg/kg, 10 mg/kg, 30 mg/kg
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Administration:i.p.
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Result:The half-life was 39 min.
Presented low levels in both brain and plasma.
Chemical Information
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CAS No. 2068692-71-5
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Appearance Solid
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Molecular Weight 678.70
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Formula C32H36F2N2O10S
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Color White to off-white
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SMILES
O=S(C(C1=CC=C(C=C1)F)C2=CC=C(C=C2)F)CCN3CCN(CC3)CC(CC4=CC=CC=C4)O.O=C(O)C(O)=O.O=C(O)C(O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 33.33 mg/mL (49.11 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Newman AH, et al., Translating the atypical dopamine uptake inhibitor hypothesis toward therapeutics for treatment of psychostimulant use disorders. Neuropsychopharmacology. 2019 Jul;44(8):1435-1444. [Content Brief]
[2]. Tunstall BJ, et al. Atypical dopamine transporter inhibitors attenuate compulsive-like methamphetamine self-administration in rats. Neuropharmacology. 2018 Mar 15;131:96-103. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.4734 mL | 7.3670 mL | 14.7341 mL | 36.8351 mL |
| 5 mM | 0.2947 mL | 1.4734 mL | 2.9468 mL | 7.3670 mL | |
| 10 mM | 0.1473 mL | 0.7367 mL | 1.4734 mL | 3.6835 mL | |
| 15 mM | 0.0982 mL | 0.4911 mL | 0.9823 mL | 2.4557 mL | |
| 20 mM | 0.0737 mL | 0.3684 mL | 0.7367 mL | 1.8418 mL | |
| 25 mM | 0.0589 mL | 0.2947 mL | 0.5894 mL | 1.4734 mL | |
| 30 mM | 0.0491 mL | 0.2456 mL | 0.4911 mL | 1.2278 mL | |
| 40 mM | 0.0368 mL | 0.1842 mL | 0.3684 mL | 0.9209 mL |
JJC8-088 dioxalate Related Classifications
HY-158013A Related Classifications
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