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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
5 Results for "
E545K
" in MedChemExpress (MCE) Product Catalog:
Products (5)
5 Results for "E545K" in MCE Product Catalog:
1
1 Cited Publications
PKI-179 is a potent and orally active dual PI3K/mTOR inhibitor, with IC50s of 8 nM, 24 nM, 74 nM, 77 nM, and 0.42 nM for PI3K-α, PI3K-β, PI3K-γ, PI3K-δ and mTOR, respectively. PKI-179 also exhibits activity over E545K and H1047R, with IC50s of 14 nM and 11 nM, respectively. PKI-179 shows anti-tumor activity in vivo .
1
1 Cited Publications
PKI-179 hydrochloride is a potent and orally active dual PI3K/mTOR inhibitor, with IC50s of 8 nM, 24 nM, 74 nM, 77 nM, and 0.42 nM for PI3K-α, PI3K-β, PI3K-γ, PI3K-δ and mTOR, respectively. PKI-179 hydrochloride also exhibits activity over E545K and H1047R, with IC50s of 14 nM and 11 nM, respectively. PKI-179 hydrochloride shows anti-tumor activity in vivo .
Cat. No.: HY-11080AR
CAS No.: 1463510-35-1
Target:
Research Areas:
PKi-179 hydrochloride (Standard) is the analytical standard of PKi-179 (hydrochloride) (HY-11080A). This product is intended for research and analytical applications. PKi-179 hydrochloride is a potent and orally active dual PI3K/mTOR inhibitor, with IC50s of 8 nM, 24 nM, 74 nM, 77 nM, and 0.42 nM for PI3K-α, PI3K-β, PI3K-γ, PI3K-δ and mTOR, respectively. PKi-179 hydrochloride also exhibits activity over E545K and H1047R, with IC50s of 14 nM and 11 nM, respectively. PKi-179 hydrochloride shows anti-tumor activity in vivo .
Cat. No.: HY-11080R
CAS No.: 1197160-28-3
Target:
Research Areas:
PKi-179 (Standard) is the analytical standard of PKi-179 (HY-11080). This product is intended for research and analytical applications. PKi-179 is a potent and orally active dual PI3K/mTOR inhibitor, with IC50s of 8 nM, 24 nM, 74 nM, 77 nM, and 0.42 nM for PI3K-α, PI3K-β, PI3K-γ, PI3K-δ and mTOR, respectively. PKi-179 also exhibits activity over E545K and H1047R, with IC50s of 14 nM and 11 nM, respectively. PKi-179 shows anti-tumor activity in vivo .
Cat. No.: HY-P703469
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: PIK3R1; PI3-Kinase Subunit P85-Alpha; Phosphoinositide-3-Kinase Regulatory Subunit 1; PI3 Kinase-Associated P85; GRB1; CDNA FLJ44373 Fis, Clone TRACH3009455, Highly Similar To Phosphatidylinositol 3-Kinase Regulatory Subunit Alpha; Phosphatidylinositol 3-Kinase 85 KDa Regulatory Subunit Alpha; Phosphatidylinositol 3-Kinase, Regulatory Subunit, Polypeptide 1 (P85 Alpha); Phosphatidylinositol 3-Kinase Regulatory Subunit Alpha; Phosphatidylinositol 3-Kinase-Associated P-85 Alpha; P85-ALPHA; PtdIns-3-Kinase Regulatory Subunit P85-Alpha; P85alpha; Phosphoinositide-3-Kinase Regulatory Subunit; P85; PI3-Kinase Regulatory Subunit Alpha; Phosphoinositide-3-Kinase, Regulatory Subunit 1 (Alpha); PIK3R1/NR4A3 Fusion Protein; Phosphoinositide-3-Kinase Regulatory Subunit Alpha; NR4A3 Fusion; PtdIns-3-Kinase Regulatory Subunit Alpha; IMD36; Growth Factor Receptor Bound 1; AGM7; PI3K Regulatory Subunit Alpha; MHC class I antigen; MHC class I protein; Mamu-A1; Mamu-A
Species:
Human
Source:
Sf9 insect cells
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
