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Cat. No.: HY-11080R

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PK_i-179 (Standard)

PK_i-179 (Standard) is the analytical standard of PK_i-179 (HY-11080). This product is intended for research and analytical applications. PK_i-179 is a potent and orally active dual PI3K/mTOR inhibitor, with IC₅₀s of 8 nM, 24 nM, 74 nM, 77 nM, and 0.42 nM for PI3K-α, PI3K-β, PI3K-γ, PI3K-δ and mTOR, respectively. PK_i-179 also exhibits activity over E545K and H1047R, with IC₅₀s of 14 nM and 11 nM, respectively. PK_i-179 shows anti-tumor activity in vivo.

For research use only. We do not sell to patients.

CAS No.: 1197160-28-3
Formula: C₂₅H₂₈N₈O₃
Molecular Weight:488.54

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Please store the product under the recommended conditions in the Certificate of Analysis.

PK_i-179 (Standard) Chemical Structure

CAS No.: 1197160-28-3

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Application

The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.

Chemical Information

CAS No. 1197160-28-3
Molecular Weight 488.54
Formula C₂₅H₂₈N₈O₃
SMILES

O=C(NC1=CC=NC=C1)NC2=CC=C(C3=NC(N4C5CCC4COC5)=NC(N6CCOCC6)=N3)C=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Venkatesan AM, et, al. PKI-179: an orally efficacious dual phosphatidylinositol-3-kinase (PI3K)/mammalian target of rapamycin (mTOR) inhibitor. Bioorg Med Chem Lett. 2010 Oct 1;20(19):5869-73. [Content Brief]

[2]. Rehan M. A structural insight into the inhibitory mechanism of an orally active PI3K/mTOR dual inhibitor, PKI-179 using computational approaches. J Mol Graph Model. 2015 Nov;62:226-234. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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PKi-179 (Standard)

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PKi-179 (Standard) Related Classifications

HY-11080R Related Classifications

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PK_i-179 (Standard)

PK_i-179 (Standard) Related Classifications