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FXIIIa

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Biochemical Assay Reagents (2) Elastase (1) Factor VIII (2) Factor Xa (1) Factor XI (1) Thrombin (1)
By Research Areas:	Cardiovascular Disease (1) Inflammation/Immunology (1)

Inhibitors & Agonists

Peptides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W783421

FXIIIa-IN-1 sodium Reactive Black 5	Biochemical Assay Reagents	Others
C.I.Reactive Black 5 (Technical Grade) is a biological molecule.

HY-162654

FXIIIa-IN-1	Factor VIII	Cardiovascular Disease
FXIIIa-IN-1 (Compound 16) is a potent and selective *FXIIIa* (Factor XIIIa) inhibitor with an IC₅₀ value of 2.4 μM. FXIIIa-IN-1 inhibits *FXIIIa* by competing with the Gln-donor protein substrate (dimethylcasein). FXIIIa-IN-1 holds promise for the development of effective and safe novel anticoagulants .

HY-P11349

TG-Gln	Biochemical Assay Reagents	Others
TG-Gln (a glutamine donor peptide with the sequence H-NQEQVSPLERCG-NH₂) is a substrate-type crosslinker targeting activated coagulation transglutaminase XIII (FXIIIa). TG-Gln is promising for research of angiogenesis induction, cartilage repair, and wound healing .

HY-160824

Neutrophil elastase-IN-7	Elastase Thrombin Factor Xa Factor XI Factor VIII	Inflammation/Immunology
Neutrophil elastase-IN-7 (Compound 12) is an effective inhibitor of neutrophil elastase (HNE), with an IC₅₀ value of 0.54 μM. Neutrophil elastase-IN-7 also exhibits significant inhibitory activity against various coagulation proteins, with the IC₅₀ values for thrombin, FXa, FXIa, and *FXIIIa* being 8.2, 12.7, 1.2, and 5.7 μM, respectively. Neutrophil elastase-IN-7 can be used for research on inflammation, innate immune responses, and tissue remodeling .

Cat. No.	Product Name	Target	Research Area

HY-P11349

TG-Gln	Biochemical Assay Reagents	Others
TG-Gln (a glutamine donor peptide with the sequence H-NQEQVSPLERCG-NH₂) is a substrate-type crosslinker targeting activated coagulation transglutaminase XIII (FXIIIa). TG-Gln is promising for research of angiogenesis induction, cartilage repair, and wound healing .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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