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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
27 Results for "
Fms like tyrosine kinase 3
" in MedChemExpress (MCE) Product Catalog:
Products (27)
27 Results for "Fms like tyrosine kinase 3" in MCE Product Catalog:
2
2 Cited Publications
Cat. No.: HY-P70178
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: FLT3; CD135 Antigen; Fms Related Receptor tyrosine kinase 3; FLK-2; CD135; Growth Factor Receptor tyrosine kinase Type III; STK1; Receptor Protein-tyrosine kinase; FLK2; Fms-Related tyrosine kinase 3; Fms-like tyrosine kinase 3; Fetal Liver kinase 2; Rece
Species:
Human
Source:
HEK293
Cat. No.: HY-172581
CAS No.: 1862226-99-0
Clifutinib is an orally active and selective internal tandem duplication mutation of FMS-like tyrosine kinase 3 (FLT3-ITD) inhibitor with an IC50 value of 15.1 nM. Clifutinib exerts strong antiproliferative effects on FLT3-ITD acute myeloid leukemia (AML) cell lines (MV-4-11: IC50 = 1.5 nM; MOLM-13: IC50 = 1.4 nM). Clifutinib inhibits the activity of FLT3-ITD kinase and blocks the downstream RAS/MAPK, PI3K/AKT, and JAK/STAT5 signaling pathways of FLT3. Clifutinib induces apoptosis of acute myeloid leukemia (AML) cells with FLT3-ITD mutations. Clifutinib demonstrates significant antitumor efficacy in mice bearing MV-4-11 or MOLM-13 xenografts. Clifutinib is promising for research of relapsed/refractory FLT3-ITD-positive acute myeloid leukemia .
Synonyms: CGP52421
3-Hydroxy Midostaurin (CGP 52421), a metabolite of PKC412, effectively inhibits FMS-like tyrosine kinase-3 (FLT3) autophosphorylation with IC50s of approximately 132 nM and 9.8 μM in culture medium and plasma, respectively. 3-Hydroxy Midostaurin is less selective but more cytotoxic than PKC412 .
Cat. No.: HY-118304B
Purity: 99.95%
AKN-028 acetate, a novel tyrosine kinase (TK) inhibitor, is a potent, orally active FMS-like receptor tyrosine kinase 3 (FLT3) inhibitor with an IC50 value of 6 nM. AKN-028 acetate inhibits FLT3 autophosphorylation. AKN-028 acetate induces dose-dependent cytotoxic response (mean IC50=1 μM). AKN-028 acetate induces apoptosisby activation of caspase 3. AKN-028 acetate can be used in research of acute myeloid leukemia (AML).
Cat. No.: HY-P991114
CAS No.: 2921564-55-6
Target:
Research Areas:
FLT3-IN-10 (compound 7c) is a potent inhibitor of FMS-like tyrosine kinase 3 (FLT3). FLT3-IN-10 has the potential for the research of FLT3-mutated acute myeloid leukemia (AML) .
Cat. No.: HY-118304
CAS No.: 1175017-90-9
AKN-028, a novel tyrosine kinase (TK) inhibitor, is a potent, orally active FMS-like receptor tyrosine kinase 3 (FLT3) inhibitor with an IC50 value of 6 nM. AKN-028 inhibits FLT3 autophosphorylation. AKN-028 induces dose-dependent cytotoxic response (mean IC50=1 μM). AKN-028 induces apoptosisby activation of caspase 3. AKN-028 can be used in research of acute myeloid leukemia (AML) .
Cat. No.: HY-175274
CAS No.: 304480-98-6
MolPort-002-705-878 is a highly selective FMS-like tyrosine kinase 3 (FLT3) inhibitor with a binding affinity of −11.33 kcal/mol. MolPort-002-705-878 inhibits the proliferation of FLT3-mutated acute myeloid leukemia (AML) cells. MolPort-002-705-878 is promising for research of FLT3-mutated AML .
Cat. No.: HY-108263S
Synonyms: CGP52421-d5
Cat. No.: HY-W751180
Synonyms: CGP52421-13C6
Cat. No.: HY-E70723
FLT3 (FMS-like tyrosine kinase 3, CD135) is a type 3 receptor tyrosine kinase that plays important roles in cell survival, proliferation, and differentiation during normal hematopoiesis. FLT3 is one of the most frequently mutated genes in acute myeloid leukemia (AML). FLT3 D835Y is the most frequent kinase domain mutation, converting aspartic acid to tyrosine. FLT3 D835Y Recombinant Human Active Protein Kinase is a recombinant FLT3 D835Y protein that can be used to study FLT3 D835Y-related functions .
Cat. No.: HY-E70724
FLT3 (FMS-like tyrosine kinase 3, CD135) is a type 3 receptor tyrosine kinase that plays important roles in cell survival, proliferation, and differentiation during normal hematopoiesis. FLT3 is one of the most frequently mutated genes in acute myeloid leukemia (AML). FLT3 ITD is a internal tandem duplication (ITD) mutation of FLT3 that may be present in AML cells. FLT3 ITD Recombinant Human Active Protein Kinase is a recombinant FLT3 ITD protein that can be used to study FLT3 ITD-related functions .
Cat. No.: HY-118304A
CAS No.: 1175017-91-0
AKN-028 TFA, a novel tyrosine kinase (TK) inhibitor, is a potent, orally active FMS-like receptor tyrosine kinase 3 (FLT3) inhibitor with an IC50 value of 6 nM. AKN-028 TFA inhibits FLT3 autophosphorylation. AKN-028 TFA induces dose-dependent cytotoxic response (mean IC50=1 μM). AKN-028 TFA induces apoptosisby activation of caspase 3. AKN-028 TFA can be used in research of acute myeloid leukemia (AML) .
Cat. No.: HY-161709
CAS No.: 2452019-67-7
Research Areas:
FLT3/CDKs ligand-1 (Compound 14) is a ligand for target protein, which promotes the degradation of cyclin-dependent kinase (CDK) and the FMS-like tyrosine kinase 3 (FLT3), inhibits FLT3/CDK related proliferations and survivals of leukemia cells. LT3/CDKs ligand-1 can be used for synthesis of PROTAC FLT3/CDKs degrader-1 (HY-161708) .
Cat. No.: HY-P74151
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: FLT3; CD135 Antigen; Fms Related Receptor tyrosine kinase 3; FLK-2; CD135; Growth Factor Receptor tyrosine kinase Type III; STK1; Receptor Protein-tyrosine kinase; FLK2; Fms-Related tyrosine kinase 3; Fms-like tyrosine kinase 3; Fetal Liver kinase 2; Rece
Species:
Mouse
Source:
HEK293
Cat. No.: HY-P75183
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: FLT3; CD135 Antigen; Fms Related Receptor tyrosine kinase 3; FLK-2; CD135; Growth Factor Receptor tyrosine kinase Type III; STK1; Receptor Protein-tyrosine kinase; FLK2; Fms-Related tyrosine kinase 3; Fms-like tyrosine kinase 3; Fetal Liver kinase 2; Rece
Species:
Human
Source:
HEK293
Cat. No.: HY-P75184
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: FLT3; CD135 Antigen; Fms Related Receptor tyrosine kinase 3; FLK-2; CD135; Growth Factor Receptor tyrosine kinase Type III; STK1; Receptor Protein-tyrosine kinase; FLK2; Fms-Related tyrosine kinase 3; Fms-like tyrosine kinase 3; Fetal Liver kinase 2; Rece
Species:
Human
Source:
HEK293
Cat. No.: HY-P700722
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: FLT3; CD135 Antigen; Fms Related Receptor tyrosine kinase 3; FLK-2; CD135; Growth Factor Receptor tyrosine kinase Type III; STK1; Receptor Protein-tyrosine kinase; FLK2; Fms-Related tyrosine kinase 3; Fms-like tyrosine kinase 3; Fetal Liver kinase 2; Rece
Species:
Cynomolgus
Source:
HEK293
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
