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Cat. No.: HY-146680

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FLT3/ITD-IN-4

FLT3/ITD-IN-4 (Compound 16) is a selective FMS-like tyrosine kinase 3 internal tandem duplications (FLT3-ITD) inhibitor with an IC₅₀ of 2.3 nM. FLT3/ITD-IN-4 can be used for acute myeloid leukemia research.

For research use only. We do not sell to patients.

CAS No.: 2278278-04-7
Formula: C₂₅H₂₂N₄O₅
Molecular Weight:458.47

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

FLT3/ITD-IN-4 Chemical Structure

CAS No.: 2278278-04-7

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

IC₅₀ & Target

FLT3-ITD

2.3 nM (IC₅₀)

FLT3 D835Y

4.84 nM (IC₅₀)

RET

277 nM (EC₅₀)

FLT3

443 nM (EC₅₀)

ZAK/MLTK

1069 nM (EC₅₀)

CDK16/Cyclin Y

1768 nM (EC₅₀)

DDR2

2494 nM (EC₅₀)

EPHA7

3255 nM (EC₅₀)

NTRK1

3857 nM (EC₅₀)

MAP4K4

5737 nM (EC₅₀)

All CDK Isoforms :

All MAP4K Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
EJM	IC₅₀	2.152 μM Compound: 16	Cytotoxicity against human EJM cells assessed as reduction in cell viability after 4 days by CellTiter-Blue assay Cytotoxicity against human EJM cells assessed as reduction in cell viability after 4 days by CellTiter-Blue assay	[PMID: 32199135]
EOL1	IC₅₀	<0.001 μM Compound: 16	Cytotoxicity against human EOL1 cells assessed as reduction in cell viability after 4 days by CellTiter-Blue assay Cytotoxicity against human EOL1 cells assessed as reduction in cell viability after 4 days by CellTiter-Blue assay	[PMID: 32199135]
HL-60	IC₅₀	2.985 μM Compound: 16	Cytotoxicity against human HL-60 cells assessed as reduction in cell viability after 4 days by CellTiter-Blue assay Cytotoxicity against human HL-60 cells assessed as reduction in cell viability after 4 days by CellTiter-Blue assay	[PMID: 32199135]
IM-9	IC₅₀	1.382 μM Compound: 16	Cytotoxicity against human IM-9 cells assessed as reduction in cell viability after 4 days by CellTiter-Blue assay Cytotoxicity against human IM-9 cells assessed as reduction in cell viability after 4 days by CellTiter-Blue assay	[PMID: 32199135]
KG-1	IC₅₀	0.383 μM Compound: 16	Cytotoxicity against human KG-1 cells assessed as reduction in cell viability after 4 days by CellTiter-Blue assay Cytotoxicity against human KG-1 cells assessed as reduction in cell viability after 4 days by CellTiter-Blue assay	[PMID: 32199135]
KG-1a	IC₅₀	0.403 μM Compound: 16	Cytotoxicity against human KG-1a cells assessed as reduction in cell viability after 4 days by CellTiter-Blue assay Cytotoxicity against human KG-1a cells assessed as reduction in cell viability after 4 days by CellTiter-Blue assay	[PMID: 32199135]
L-363	IC₅₀	0.339 μM Compound: 16	Cytotoxicity against human L-363 cells assessed as reduction in cell viability after 4 days by CellTiter-Blue assay Cytotoxicity against human L-363 cells assessed as reduction in cell viability after 4 days by CellTiter-Blue assay	[PMID: 32199135]
LP-1	IC₅₀	0.22 μM Compound: 16	Cytotoxicity against human LP-1 cells assessed as reduction in cell viability after 4 days by CellTiter-Blue assay Cytotoxicity against human LP-1 cells assessed as reduction in cell viability after 4 days by CellTiter-Blue assay	[PMID: 32199135]
MOLM-13	IC₅₀	<0.001 μM Compound: 16	Cytotoxicity against human MOLM-13 cells assessed as reduction in cell viability after 4 days by CellTiter-Blue assay Cytotoxicity against human MOLM-13 cells assessed as reduction in cell viability after 4 days by CellTiter-Blue assay	[PMID: 32199135]
MV4-11	IC₅₀	<0.001 μM Compound: 16	Cytotoxicity against human MV4-11 cells assessed as reduction in cell viability after 4 days by CellTiter-Blue assay Cytotoxicity against human MV4-11 cells assessed as reduction in cell viability after 4 days by CellTiter-Blue assay	[PMID: 32199135]
MV4-11	IC₅₀	0.64 nM Compound: 16	Cytotoxicity against human MV4-11 cells assessed as reduction in cell viability after 72 hrs by trypan blue dye exclusion method Cytotoxicity against human MV4-11 cells assessed as reduction in cell viability after 72 hrs by trypan blue dye exclusion method	[PMID: 32199135]
NOMO-1	IC₅₀	1.638 μM Compound: 16	Cytotoxicity against human NOMO-1 cells assessed as reduction in cell viability after 4 days by CellTiter-Blue assay Cytotoxicity against human NOMO-1 cells assessed as reduction in cell viability after 4 days by CellTiter-Blue assay	[PMID: 32199135]
OCI-AML2	IC₅₀	1.192 μM Compound: 16	Cytotoxicity against human OCI-AML2 cells assessed as reduction in cell viability after 4 days by CellTiter-Blue assay Cytotoxicity against human OCI-AML2 cells assessed as reduction in cell viability after 4 days by CellTiter-Blue assay	[PMID: 32199135]
OCI-AML-3	IC₅₀	3.424 μM Compound: 16	Cytotoxicity against human OCI-AML-3 cells assessed as reduction in cell viability after 4 days by CellTiter-Blue assay Cytotoxicity against human OCI-AML-3 cells assessed as reduction in cell viability after 4 days by CellTiter-Blue assay	[PMID: 32199135]
OPM-2	IC₅₀	0.343 μM Compound: 16	Cytotoxicity against human OPM-2 cells assessed as reduction in cell viability after 4 days by CellTiter-Blue assay Cytotoxicity against human OPM-2 cells assessed as reduction in cell viability after 4 days by CellTiter-Blue assay	[PMID: 32199135]
RPMI-8226	IC₅₀	1.679 μM Compound: 16	Cytotoxicity against human RPMI-8226 cells assessed as reduction in cell viability after 4 days by CellTiter-Blue assay Cytotoxicity against human RPMI-8226 cells assessed as reduction in cell viability after 4 days by CellTiter-Blue assay	[PMID: 32199135]
THP-1	IC₅₀	1.686 μM Compound: 16	Cytotoxicity against human THP-1 cells assessed as reduction in cell viability after 4 days by CellTiter-Blue assay Cytotoxicity against human THP-1 cells assessed as reduction in cell viability after 4 days by CellTiter-Blue assay	[PMID: 32199135]
U-266	IC₅₀	2.163 μM Compound: 16	Cytotoxicity against human U-266 cells assessed as reduction in cell viability after 4 days by CellTiter-Blue assay Cytotoxicity against human U-266 cells assessed as reduction in cell viability after 4 days by CellTiter-Blue assay	[PMID: 32199135]

Chemical Information

CAS No. 2278278-04-7
Molecular Weight 458.47
Formula C₂₅H₂₂N₄O₅
SMILES

CC(C)(C1=CC(NC(NC2=CC=C3OC(C(C4=CC5=C(N4)C=CC(O)=C5)=O)=CC3=C2)=O)=NO1)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Sellmer A, et al. A series of novel aryl-methanone derivatives as inhibitors of FMS-like tyrosine kinase 3 (FLT3) in FLT3-ITD-positive acute myeloid leukemia. Eur J Med Chem. 2020 May 1;193:112232. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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FLT3/ITD-IN-4

All CDK Isoforms

All MAP4K Isoforms