1. Protein Tyrosine Kinase/RTK
    Cell Cycle/DNA Damage
    MAPK/ERK Pathway
  2. FLT3
    RET
    CDK
    MAP4K
  3. FLT3/ITD-IN-4

FLT3/ITD-IN-4 

Cat. No.: HY-146680
Handling Instructions

FLT3/ITD-IN-4 (Compound 16) is a selective FMS-like tyrosine kinase 3 internal tandem duplications (FLT3-ITD) inhibitor with an IC50 of 2.3 nM. FLT3/ITD-IN-4 can be used for acute myeloid leukemia research.

For research use only. We do not sell to patients.

FLT3/ITD-IN-4 Chemical Structure

FLT3/ITD-IN-4 Chemical Structure

CAS No. : 2278278-04-7

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Description

FLT3/ITD-IN-4 (Compound 16) is a selective FMS-like tyrosine kinase 3 internal tandem duplications (FLT3-ITD) inhibitor with an IC50 of 2.3 nM. FLT3/ITD-IN-4 can be used for acute myeloid leukemia research[1].

IC50 & Target

FLT3-ITD

2.3 nM (IC50)

FLT3 D835Y

4.84 nM (IC50)

RET

277 nM (EC50)

FLT3

443 nM (EC50)

ZAK/MLTK

1069 nM (EC50)

CDK16/Cyclin Y

1768 nM (EC50)

DDR2

2494 nM (EC50)

EPHA7

3255 nM (EC50)

NTRK1

3857 nM (EC50)

MAP4K4

5737 nM (EC50)

Molecular Weight

458.47

Formula

C25H22N4O5

CAS No.
SMILES

CC(C)(C1=CC(NC(NC2=CC=C3OC(C(C4=CC5=C(N4)C=CC(O)=C5)=O)=CC3=C2)=O)=NO1)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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FLT3/ITD-IN-4
Cat. No.:
HY-146680
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