18 Results for "

GALA

" in MedChemExpress (MCE) Product Catalog:
Products (18)

18 Results for "GALA" in MCE Product Catalog:

Cat. No.: HY-P5423
CAS No.: 107658-43-5
Target:  

Exosomes Liposome

Research Areas:  

Cancer

GALA is a pH-responsive amphipathic peptide consisting of 30 amino acids, which acts as a lung endothelium-targeting ligand. GALA undergoes a conformational transition from random coil to α-helix in an acidic environment at pH 5.0, thereby inducing endosomal membrane destabilization and fusion. GALA-modified liposomes traverse lung endothelial cells via clathrin-dependent endocytosis and transcytosis, and specifically accumulate in the lungs after intravenous injection. GALA significantly promotes the cytosolic release of cargos carried by exosomes, plasmids and liposomes, effectively enhances gene transfection efficiency, and drives gene knockdown of functional macromolecules (such as siRNA) in alveolar epithelial cells (with no significant cytotoxicity at effective concentrations). GALA serves as a critical tool for studies on lung cancer metastasis (e.g., melanoma lung metastasis) and lung-targeted drug delivery systems .
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Cat. No.: HY-P5423A
Target:  

Peptides

Research Areas:  

Others

GALA (TFA) is a biological active peptide (GALA, a pH-sensitive fusogenic peptide, is a promising method to accelerate this step in order to enhance the expression of the desired proteins.) .
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Cat. No.: HY-N10526
CAS No.: 41744-59-6
Synonyms: GALA-3Galb-4Glc
Target:  

Others

Isoglobotriaose (Gala-3Galb-4Glc) is a glycosphingolipid found in mammalian tissues. Isoglobotriaose is an analogue of Globotriaose, the ganglioside derivatives of them locate in difference position of small intestine, isoglobotriaosylceramide is restricted to the nonepithelial residue, while globotriaosylceramide is in both compartments .
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Cat. No.: HY-E70036
Target:  

Endogenous Metabolite

Research Areas:  

Metabolic Disease

Galcuronokinase (AtGalAK) is a member of the GHMP kinase family. Galcuronokinase (AtGalAK) catalyzes the ATP-dependent conversion of alpha-d-galacturonic acid (d-GalA) to alpha-d-galacturonic acid-1-phosphate (GalA-1-P) .
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Cat. No.: HY-RS05463
Research Areas:  

Others

GLA Human Pre-designed siRNA Set A contains three designed siRNAs for GLA gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-179514
CAS No.: 3092129-97-7
Synonyms: GALA-SR1078
Target:  

ROR

Research Areas:  

Inflammation/Immunology

Gala-SR (Gala-SR1078) is an RORα agonist. Gala-SR ameliorates rhythm disorders by enhancing the amplitude of the circadian rhythm. Gala-SR can be used for the study of periodontitis .
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Cat. No.: HY-P11766
Synonyms: GALA-cholesterol
Research Areas:  

Cancer

GALA-chol is a cholesterol-conjugated pH-responsive fusion peptide that can serve as a delivery adjuvant. GALA-chol enhances the endocytosis of siRNA RET/PTC1-SQ nanoparticles, inhibits cell viability, and undergoes pH-responsive charge conversion in the acidic lysosomal environment, thereby promoting lysosomal escape of small extracellular vesicle (sEV) cargo. GALA-chol anchors to the sEV membrane and maintains the structural integrity and intrinsic homing activity of sEVs. GALA-chol can be used in studies related to adjuvant delivery .
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Cat. No.: HY-P5423C
Target:  

Peptides

Research Areas:  

Others

GALA-Cys is a chemically modified GALA peptide (HY-P5423) that retains GALA functions while acquiring strong covalent conjugation capability. GALA-Cys undergoes pH-driven reversible secondary structure transition, rearranges into an amphipathic α-helix, self-oligomerizes, penetrates lipid membranes to form pores, and disrupts lipid bilayers, thereby enabling endosomal escape and cytosolic cargo delivery. GALA-Cys can be conjugated with lipid DPTE for integration into liposomes, self-assembles into a tilted monolayer on gold surfaces, and serves as a pH-responsive coating for particle surface functionalization. GALA-Cys is applicable to studies related to targeted cargo delivery .
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Cat. No.: HY-182098
DSPE-PEG1000-GALA is a PEG compound which composed of DSPE and a lung endothelium-targeting peptide GALA (HY-P5423). GALA is a pH-responsive amphipathic peptide consisting of 30 amino acids, which acts as a lung endothelium-targeting ligand. GALA undergoes a conformational transition from random coil to α-helix in an acidic environment at pH 5.0, thereby inducing endosomal membrane destabilization and fusion. GALA-modified liposomes traverse lung endothelial cells via clathrin-dependent endocytosis and transcytosis, and specifically accumulate in the lungs after intravenous injection. DSPE-PEG1000-GALA can be used for drug delivery .
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Cat. No.: HY-182098A
DSPE-PEG2000-GALA is a PEG compound which composed of DSPE and a lung endothelium-targeting peptide GALA (HY-P5423). GALA is a pH-responsive amphipathic peptide consisting of 30 amino acids, which acts as a lung endothelium-targeting ligand. GALA undergoes a conformational transition from random coil to α-helix in an acidic environment at pH 5.0, thereby inducing endosomal membrane destabilization and fusion. GALA-modified liposomes traverse lung endothelial cells via clathrin-dependent endocytosis and transcytosis, and specifically accumulate in the lungs after intravenous injection. DSPE-PEG2000-GALA can be used for drug delivery .
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Cat. No.: HY-182098B
DSPE-PEG3400-GALA is a PEG compound which composed of DSPE and a lung endothelium-targeting peptide GALA (HY-P5423). GALA is a pH-responsive amphipathic peptide consisting of 30 amino acids, which acts as a lung endothelium-targeting ligand. GALA undergoes a conformational transition from random coil to α-helix in an acidic environment at pH 5.0, thereby inducing endosomal membrane destabilization and fusion. GALA-modified liposomes traverse lung endothelial cells via clathrin-dependent endocytosis and transcytosis, and specifically accumulate in the lungs after intravenous injection. DSPE-PEG3400-GALA can be used for drug delivery .
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Cat. No.: HY-182098C
DSPE-PEG5000-GALA is a PEG compound which composed of DSPE and a lung endothelium-targeting peptide GALA (HY-P5423). GALA is a pH-responsive amphipathic peptide consisting of 30 amino acids, which acts as a lung endothelium-targeting ligand. GALA undergoes a conformational transition from random coil to α-helix in an acidic environment at pH 5.0, thereby inducing endosomal membrane destabilization and fusion. GALA-modified liposomes traverse lung endothelial cells via clathrin-dependent endocytosis and transcytosis, and specifically accumulate in the lungs after intravenous injection. DSPE-PEG5000-GALA can be used for drug delivery .
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Cat. No.: HY-P5423D
Target:  

Exosomes

Research Areas:  

Others

Ahx-GALA-Cys is a GALA peptide (HY-P5423) derivative with an N-terminal 6-aminohexanoic acid (Ahx) linker and a C-terminal cysteine residue. Ahx-GALA-Cys possesses strong covalent coupling capacity, which can be used to conjugate fluorophores and targeting ligands for investigating the surface functionalization of small extracellular vesicles (sEV) and lysosomal escape .
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Cat. No.: HY-P73077
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Alpha-GALActosidase A; GALA; GLA; Melibiase
Species:  
Source:  
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Cat. No.: HY-P82333
Synonyms: Alpha gal A; GALA; GALActosidase; alpha; GLA; Melibiase

Host:  

Rabbit

Application:  

WB, IHC-P, ICC/IF, IP, FC

Reactivity:  

Human

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Cat. No.: HY-P76955
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: Glycosyltransferase 8 domain-containing protein 2; GALA4A
Species:  
Source:  
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Cat. No.: HY-W714238
CAS No.: 1172134-12-1
Target:  

Drug Metabolite

Research Areas:  

Others

Spirotetramat-mono-hydroxy is a metabolite of Spirotetramat (HY-120253). Spirotetramat is an insecticide .
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Cat. No.: HY-P77849
Purity:  ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: Sialyltransferase 4C; SIAT4; SIAT4C; SIAT4-C; ST3Gal IV; ST3GAL4; ST3GALA.2; ST-4; STZSIAT4; Alpha 2,3-ST 4; CGS23; CGS23FLJ46764; FLJ11867; Gal-NAc 6S; NANTA3; SAT3; SAT-3
Species:  
Source:  
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