Isoglobotriaose  (Synonyms: Gala-3Galb-4Glc)

Isoglobotriaose (Gala-3Galb-4Glc) is a glycosphingolipid found in mammalian tissues. Isoglobotriaose is an analogue of Globotriaose, the ganglioside derivatives of them locate in difference position of small intestine, isoglobotriaosylceramide is restricted to the nonepithelial residue, while globotriaosylceramide is in both compartments^[1][2].

Isoglobotriaose is synthesized from lactose, glucose-1-phophate (Glc-1-P), and uridine 5’-triphosphate (UTP) by a one-pot three-enzyme system containing UDP-glucose pyrophosphorylase (GlaU), UDP-Gal 4-epimerase (GalE), and an α1-3galactosytransferase (α1-3GalT)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

504.44

C₁₈H₃₂O₁₆

41744-59-6

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• [1]. Li W, et al. Strategies for chemoenzymatic synthesis of carbohydrates. Carbohydr Res. 2019 Jan 15;472:86-97.   [Content Brief]

  [2]. Breimer ME, et al. Glycosphingolipids of rat tissues. Different composition of epithelial and nonepithelial cells of small intestine. J Biol Chem. 1982 Jan 10;257(1):557-68.  [Content Brief]