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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
10 Results for "
GPR139
" in MedChemExpress (MCE) Product Catalog:
Products (10)
10 Results for "GPR139" in MCE Product Catalog:
1
1 Cited Publications
Cat. No.: HY-19838
CAS No.: 1802326-66-4
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JNJ-63533054 is a potent, selective and orally active GPR139 agonist with an EC50 of 16 nM for human GPR139 (hGPR139). JNJ-63533054 shows selective for GPR139 over other GPCRs, ion channels, and transporters. JNJ-63533054 can cross the blood-brain barrier (BBB) .
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1 Cited Publications
Synonyms: TAK-041; NBI-1065846
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Zelatriazin (TAK-041; NBI-1065846) is a potent and selective GPR139 agonist with an EC50 of 22 nM. Zelatriazin has the potential for the research of negative symptoms associated with schizophrenia .
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NCRW0005-F05 is a GPR139 antagonist with an IC50 of 147.9 nM against zebrafish GPR139. NCRW0005-F05 blocks agonist-induced GPR139 activity and inhibits intracellular calcium mobilization. NCRW0005-F05 suppresses fear memory consolidation, increases and decreases the peak amplitude of calcium transients, reduces KCl-induced calcium transients, induces thigmotaxis, and decreases locomotor speed after conditioning. NCRW0005-F05 can be used in research related to Parkinson's disease, diabetes, and obesity .
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GPR139 agonist-2 (compound 20a) is a potent GPR139 agonist with an EC50 of 24.7 nM. GPR139 agonist-2 rescues the social interaction deficits and alleviates cognitive deficits in murine schizophrenia models. GPR139 agonist-2 has the potential for antischizophrenia drug research .
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LP-471756 is a potent GPR139 antagonist with an IC50 value of 640 nM. LP-471756 inhibits LP-360924-stimulated cAMP production .
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TC-O 9311 is a potent orphan G protein-coupled receptor 139 (GPR139) agonist with an EC50 of 39 nM .
Cat. No.: HY-RS05660
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GPR139 Human Pre-designed siRNA Set A contains three designed siRNAs for GPR139 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS05661
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Gpr139 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Gpr139 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS05662
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Gpr139 Rat Pre-designed siRNA Set A contains three designed siRNAs for Gpr139 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-101777R
CAS No.: 444932-31-4
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TC-O 9311 (Standard) is the analytical standard of TC-O 9311 (HY-101777). This product is intended for research and analytical applications. TC-O 9311 is a potent orphan G protein-coupled receptor 139 (GPR139) agonist with an EC50 of 39 nM .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
