342779-66-2
Chemical Structure
NCRW0005-F05
- CAS No.: 342779-66-2
- Formula:C16H13F2NO2
- Molecular Weight:289.28
IUPAC Name: 3,3-difluoro-4-(4-methoxyphenyl)-1-phenylazetidin-2-one
InChIKey: AIIIYUSGINMZMS-UHFFFAOYSA-N
SMILES: O=C1N(C2=CC=CC=C2)C(C3=CC=C(OC)C=C3)C1(F)F
Biological Activity: NCRW0005-F05 is a GPR139 antagonist with an IC50 of 147.9 nM against zebrafish GPR139. NCRW0005-F05 blocks agonist-induced GPR139 activity and inhibits intracellular calcium mobilization. NCRW0005-F05 suppresses fear memory consolidation, increases and decreases the peak amplitude of calcium transients, reduces KCl-induced calcium transients, induces thigmotaxis, and decreases locomotor speed after conditioning. NCRW0005-F05 can be used in research related to Parkinson's disease, diabetes, and obesity[1][2].
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NCRW0005-F05 | 99.94% | NCRW0005-F05 is a GPR139 antagonist with an IC50 of 147.9 nM against zebrafish GPR139. NCRW0005-F05 blocks agonist-induced GPR139 activity and inhibits intracellular calcium mobilization. NCRW0005-F05 suppresses fear memory consolidation, increases and decreases the peak amplitude of calcium transients, reduces KCl-induced calcium transients, induces thigmotaxis, and decreases locomotor speed after conditioning. NCRW0005-F05 can be used in research related to Parkinson's disease, diabetes, and obesity. | ||||||||||||||||||||
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References
- [1]. Wang J, et al. High-throughput screening of antagonists for the orphan G-protein coupled receptor GPR139. Acta pharmacologica Sinica. 2015 Jul;36(7):874-8. [Content Brief]
- [2]. Roy N, et al. GPR139 agonist and antagonist differentially regulate retrieval and consolidation of fear memory in the zebrafish. Frontiers in neuroscience. 2024;18:1461148. [Content Brief]
