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Results for "

GPR39

" in MedChemExpress (MCE) Product Catalog:

14

Inhibitors & Agonists

2

Biochemical Assay Reagents

3

Peptides

3

Oligonucleotides

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-103007
    TC-G-1008
    4 Publications Verification

    GPR39-C3

    		 GPR39 Metabolic Disease Endocrinology
    TC-G-1008 (GPR39-C3) is a potent and orally available GPR39 agonist with EC50 values of 0.4 and 0.8 nM for rat and human receptors respectively.
    TC-G-1008
  • HY-137255
    Taurolithocholic acid 3-sulfate disodium

    3-Sulfotaurolithocholic acid disodium

    		 GPR39 Inflammation/Immunology
    Taurolithocholic acid 3-sulfate disodium is a GPR39 agonist with EC50s of 71.6  and 69.4 (absence of Zn 2+) and 9 and 9.6 μM (presence of Zn 2+) in M39-20 and hGPR39-2 cells, respectively. Taurolithocholic acid 3-sulfate disodium stimulates GPR39 receptors to initiate intracellular calcium signaling, independent of Zn 2+ binding sites H17 and H19. Taurolithocholic acid 3-sulfate disodium can be used for the research of gallbladder disease .
    Taurolithocholic acid 3-sulfate disodium
  • HY-113238A
    Lithocholic acid 3-sulfate disodium

    Sulfolithocholic acid disodium; LCAS disodium

    		 GPR39 ROR Metabolic Disease Inflammation/Immunology
    Lithocholic acid 3-sulfate disodium is a GPR39 agonist, with EC50 values of 41 μM and 42.4 μM in M39-20 and hGPR39-2 cells, respectively, in the absence of Zn 2+, and 0.88 μM and 0.97 μM in the presence of Zn 2+. Lithocholic acid 3-sulfate disodium acts as a RORγt ligand. Lithocholic acid 3-sulfate disodium stimulates the GPR39 receptor to initiate intracellular calcium signaling, independent of the Zn 2+-binding sites H17 and H19. LCA-3-S selectively inhibits Th17 cell differentiation by targeting RORγt. Lithocholic acid 3-sulfate disodium can be used in the research of cholestatic liver diseases .
    Lithocholic acid 3-sulfate disodium
  • HY-108699
    TM-N1324

    		GPR39 Neurological Disease Endocrinology
    TM-N1324 is an agonist of G-Protein-Coupled Receptor 39 (GPR39) with EC50s of 9 nM/5 nM in the presence of Zn 2+, and 280 nM/180 nM in the absence of Zn 2+ for human/murine GPR39.
    TM-N1324
  • HY-W587430
    Glycolithocholic acid 3-sulfate disodium

    Glycolithocholate sulfate disodium; Sulfolithocholylglycine disodium; SLCG disodium

    		 HIV GPR39 Infection Inflammation/Immunology
    Glycolithocholic acid 3-sulfate disodium is a GPR39 agonist with EC50s of 47.9  and 66.8 μM (absence of Zn 2+) and 8 and 8.7 μM (presence of Zn 2+) in M39-20 and hGPR39-2 cells, respectively. Glycolithocholic acid 3-sulfate disodium stimulates GPR39 receptors to initiate intracellular calcium signaling, independent of Zn 2+ binding sites H17 and H19. Glycolithocholic acid 3-sulfate disodium also inhibits replication of HIV-1 in vitro. Glycolithocholic acid 3-sulfate disodium can be used for the research of HIV infection and gallbladder disease .
    Glycolithocholic acid 3-sulfate disodium
  • HY-P1421
    Obestatin(human)

    		PERK GHSR Apoptosis Metabolic Disease
    Obestatin(human) is a 23-amino acid amidated peptide that regulates appetite and gastrointestinal motility via its interaction with GPR39. Obestatin(human) can be used for weight loss. Obestatin(human) cannot penetrate the cell membrane .
    Obestatin(human)
  • HY-RS17549
    Gpr39 Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Gpr39 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Gpr39 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Gpr39 Mouse Pre-designed siRNA Set A
    Gpr39 Mouse Pre-designed siRNA Set A
  • HY-RS05711
    GPR39 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    GPR39 Human Pre-designed siRNA Set A contains three designed siRNAs for GPR39 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    GPR39 Human Pre-designed siRNA Set A
    GPR39 Human Pre-designed siRNA Set A
  • HY-RS24008
    Gpr39 Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Gpr39 Rat Pre-designed siRNA Set A contains three designed siRNAs for Gpr39 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Gpr39 Rat Pre-designed siRNA Set A
    Gpr39 Rat Pre-designed siRNA Set A
  • HY-P1306
    Obestatin(rat)

    		GHSR Cardiovascular Disease Inflammation/Immunology
    Obestatin(rat), encoded by the Ghrelin gene, is a cpeptide, comprised of 23 amino acids. Obestatin(rat) suppresses food intake, inhibits jejunal contraction, and decreases body-weight gain. Obestatin is an endogenous ligand of G-protein coupled receptor 39 (GPR39). Obestatin(rat) has anti-inflammatory, anti-myocardial infarction and antioxidant activities .
    Obestatin(rat)
  • HY-P1306A
    Obestatin(rat) TFA

    		GHSR Cardiovascular Disease Inflammation/Immunology
    Obestatin(rat) TFA, encoded by the Ghrelin gene, is a cpeptide, comprised of 23 amino acids. Obestatin(rat) TFA suppresses food intake, inhibits jejunal contraction, and decreases body-weight gain. Obestatin is an endogenous ligand of G-protein coupled receptor 39 (GPR39). Obestatin(rat) TFA has anti-inflammatory, anti-myocardial infarction and antioxidant activities .
    Obestatin(rat) TFA
  • HY-182367
    TMN-OMe

    		GPR39 Neurological Disease
    TMN-OMe is a blood-brain barrier-permeable GPR39 agonist and a radiotracer for positron emission tomography (PET). TMN-OMe activates GPR39 by recruiting β-arrestin, exhibits highly selective binding ability in the mouse brain, and enables quantitative analysis of GPR39 at the in vivo level. TMN-OMe shows specific uptake in GPR39 knockout mice, Alzheimer's disease model (APP/PS1) mice, and blocking experiments. TMN-OMe facilitates in-depth exploration of changes in GPR39-related mechanisms in neurological diseases and is widely used in Alzheimer's disease research .
    TMN-OMe
  • HY-103007R
    TC-G-1008 (Standard)

    GPR39-C3 (Standard)

    		 Reference Standards GPR39 Metabolic Disease Endocrinology
    TC-G-1008 (Standard) is the analytical standard of TC-G-1008 (HY-103007). This product is intended for research and analytical applications. TC-G-1008 (GPR39-C3) is a potent and orally available GPR39 agonist with EC50 values of 0.4 and 0.8 nM for rat and human receptors respectively.
    TC-G-1008 (Standard)
  • HY-108699R
    TM-N1324 (Standard)

    		Reference Standards GPR39 Neurological Disease Endocrinology
    TM-N1324 (Standard) is the analytical standard of TM-N1324 (HY-108699). This product is intended for research and analytical applications. TM-N1324 is an agonist of G-Protein-Coupled Receptor 39 (GPR39) with EC50s of 9 nM/5 nM in the presence of Zn2+, and 280 nM/180 nM in the absence of Zn2+ for human/murine GPR39.
    TM-N1324 (Standard)

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