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Results for "

HGPS

" in MedChemExpress (MCE) Product Catalog:

9

Inhibitors & Agonists

2

Peptides

3

Antibodies

3

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-16706A
    Remodelin hydrobromide
    Maximum Cited Publications
    17 Publications Verification

    		 Histone Acetyltransferase Cancer
    Remodelin hydrobromide is an orally active and selective inhibitor of acetyltransferase NAT10. Remodelin hydrobromide inhibits NAT10 activitity and slows DNA replication and suppresses growth of prostate cancer cells. Remodelin hydrobromide inhibits the growth of prostate cancer and hepatocellular carcinoma in xenograft model. Remodelin hydrobromide enhances the healthspan in hutchinson-gilford progeria syndrome (HGPS) mouse model .
    Remodelin hydrobromide
  • HY-16706
    Remodelin
    Maximum Cited Publications
    17 Publications Verification

    		 Histone Acetyltransferase Cancer
    Remodelin is an orally active and selective inhibitor of acetyltransferase NAT10. Remodelin inhibits NAT10 activitity and slows DNA replication and suppresses growth of prostate cancer cells. Remodelin inhibits the growth of prostate cancer and hepatocellular carcinoma in xenograft model. Remodelin enhances the healthspan in hutchinson-gilford progeria syndrome (HGPS) mouse model .
    Remodelin
  • HY-159834
    Progerinin

    SLC-D011

    		 DNA/RNA Synthesis Others
    Progerinin (SLC-D011) is an orally active progerin-lamin A binding inhibitor. Progerinin selectively binds to the C-terminal region of progerin, disrupting its interaction with lamin A and promoting progerin degradation while sparing wild-type lamin A, B, and C. Progerinin ameliorates nuclear deformation, increases H3K9me3 levels, and reduces progerin expression in HGPS patient-derived fibroblasts. Progerinin extends lifespan in Lmna G609G/G609G mice and Lmna G609G/+ mice, improves body weight, hair morphology, cardiac function, and histological phenotypes. Progerinin can be used for the study of Hutchinson-Gilford progeria syndrome (HGPS) .
    Progerinin
  • HY-P1585
    Gp100 (25-33), human
    1 Publications Verification

    Hgp100 (25-33)

    		 MHC Cancer
    Gp100 (25-33), human (Hgp100 (25-33)) is the amino acids 25-33 fragment of the human melanoma antigen. Gp100 (25-33), human is a 9-amino acid (AA) epitope restricted by MHC class I H-2D b and recognized by the T cells. Gp100 (25-33), human has immunogenicity and induces specific T cells. Gp100 (25-33), human can be used for the cancer research, such as melanoma .
    Gp100 (25-33), human
  • HY-P1585A
    Gp100 (25-33), human TFA
    1 Publications Verification

    Hgp100 (25-33) TFA

    		 MHC Cancer
    Gp100 (25-33), human TFA (Hgp100 (25-33) (TFA)) is the amino acids 25-33 fragment of the human melanoma antigen. Gp100 (25-33), human TFA is a 9-amino acid (AA) epitope restricted by MHC class I H-2D b and recognized by the T cells. Gp100 (25-33), human TFA has immunogenicity and induces specific T cells. Gp100 (25-33), human TFA can be used for the cancer research, such as melanoma .
    Gp100 (25-33), human TFA
  • HY-RS07714
    LMNA Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    LMNA Human Pre-designed siRNA Set A contains three designed siRNAs for LMNA gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    LMNA Human Pre-designed siRNA Set A
    LMNA Human Pre-designed siRNA Set A
  • HY-149708
    UCM-13207

    		ICMT Others
    UCM-13207 is a selective isoprenylcysteine carboxylmethyltransferase (ICMT) inhibitor with a human IC50 of 1.4 μM and human Ka of 7.2 μM. UCM-13207 modulates progerin localization, stability, and levels, reduces DNA damage, increases cellular viability, and decreases tissue senescence. UCM-13207 can be used for the research of Hutchinson−Gilford progeria syndrome .
    UCM-13207
  • HY-RS12112
    ROBO3 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    ROBO3 Human Pre-designed siRNA Set A contains three designed siRNAs for ROBO3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    ROBO3 Human Pre-designed siRNA Set A
    ROBO3 Human Pre-designed siRNA Set A
  • HY-RS16088
    ZMPSTE24 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    ZMPSTE24 Human Pre-designed siRNA Set A contains three designed siRNAs for ZMPSTE24 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    ZMPSTE24 Human Pre-designed siRNA Set A
    ZMPSTE24 Human Pre-designed siRNA Set A

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