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Results for "

HOX

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Androgen Receptor (3) Apoptosis (6) Drug Isomer (1) Endogenous Metabolite (1) Epigenetic Reader Domain (3) FLT3 (2) Histone Methyltransferase (2) NF-κB (1) Orexin Receptor (OX Receptor) (1) Reference Standards (2) WDR5 (2)
By Research Areas:	Cancer (9) Cardiovascular Disease (3) Inflammation/Immunology (1) Neurological Disease (1)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-122611A

CSRM617 hydrochloride 1 Publications Verification	Androgen Receptor Apoptosis	Cancer
CSRM617 hydrochloride is a selective small-molecule inhibitor of the transcription factor ONECUT2 (OC2, a master regulator of androgen receptor) with a K_d of 7.43 uM in SPR assays, binding to OC2-HOX domain directly. CSRM617 hydrochloride induces apoptosis by appearance of cleaved Caspase-3 and PARP. CSRM617 hydrochloride is well tolerated in the prostate cancer mouse model

HY-156794

Enzomenib DSP-5336	Epigenetic Reader Domain FLT3	Cancer
Enzomenib (DSP-5336) is an orally active Menin inhibitor (IC₅₀=1.4 nM, K_d=6.0 nM). Enzomenib disrupts the interaction between Menin and KMT2A/MLL fusion proteins, specifically inhibits the expression of leukemia driver genes such as *HOX/MEIS1, and upregulates ITGAM. Enzomenib effectively induces cell differentiation, inhibits tumor cell proliferation, and suppresses primitive cell colony formation. Enzomenib reduces disease burden and prolongs survival, but causes adverse reactions including differentiation syndrome and QTc* interval prolongation. Enzomenib is used for research on relapsed/refractory acute myeloid leukemia, acute lymphoblastic leukemia, and other hematologic malignancies with mixed lineage leukemia (MLL) rearrangements or NPM1 mutations .

HY-172416

Balomenib ZE63-0302	Epigenetic Reader Domain	Cancer
Balomenib (ZE63-0302) is an orally bioavailable menin-KMT2A interaction inhibitor. Balomenib disrupts menin-KMT2A binding, reverses aberrant *HOX* gene expression. Balomenib inhibits *Meis1* mRNA expression in KMT2A-rearranged acute myeloid leukemia cells. Balomenib can be used for the research of leukemia .

HY-P3245A

HXR9 hydrochloride	Apoptosis	Cancer
HXR9 hydrochloride is a cell-permeable peptide and a competitive antagonist of HOX/PBX interaction. HXR9 hydrochloride antagonizes the interaction between HOX and a second transcrip-tion factor (PBX), which binds to HOX proteins in paralogue groups1 to 8. HXR9 hydrochloride selectively decreases cell proliferation and promotes apoptosis in cells with a high level of expression of the HOXA/PBX3 genes, such as MLL-rearranged leukemic cells .

HY-P10948A

CS-VIP 8 hydrochloride	WDR5 Histone Methyltransferase	Cardiovascular Disease
CS-VIP 8 hydrochloride is a selective allosteric WDR5 protein inhibitor (K_i= 0.008 μM). CS-VIP 8 hydrochloride induces conformational changes in the MLL1 complex, leading to the dissociation of MLL1 from the complex, inhibiting MLL1 histone methyltransferase activity and regulating HOX gene expression. CS-VIP 8 hydrochloride is promising for research of hematological diseases such as leukemia .

HY-134188

JNJ-54717793	Orexin Receptor (OX Receptor)	Neurological Disease
JNJ-54717793, as a brain penetrant, is an orally active, selective and high affinity orexin-1 receptor (OX1R) antagonist (plasma EC₅₀=85 ng/mL). The K_i values of JNJ-54717793 for hOX1R (human OX1R) and hOX2R are 16 nM and 700 nM, respectively. JNJ-54717793 is a potent compound of anxiety disorders .

HY-122611

CSRM617	Androgen Receptor Apoptosis	Cancer
CSRM617 is a selective small-molecule inhibitor of the transcription factor ONECUT2 (OC2, a master regulator of androgen receptor) with a K_d of 7.43 uM in SPR assays, binding to OC2-HOX domain directly. CSRM617 induces apoptosis by appearance of cleaved Caspase-3 and PARP. CSRM617 is well tolerated in the prostate cancer mouse model

HY-P10948

CS-VIP 8	WDR5 Histone Methyltransferase	Cardiovascular Disease
CS-VIP 8 is a selective allosteric WDR5 protein inhibitor (K_i= 0.008 μM). CS-VIP 8 induces conformational changes in the MLL1 complex, leading to the dissociation of MLL1 from the complex, inhibiting MLL1 histone methyltransferase activity and regulating HOX gene expression. CS-VIP 8 is promising for research of hematological diseases such as leukemia .

HY-P3245

HXR9	Apoptosis	Cancer
HXR9 is a cell-permeable peptide and a competitive antagonist of HOX/PBX interaction. HXR9 antagonizes the interaction between HOX and a second transcrip-tion factor (PBX), which binds to HOX proteins in paralogue groups1 to 8. HXR9 selectively decreases cell proliferation and promotes apoptosis in cells with a high level of expression of the HOXA/PBX3 genes, such as MLL-rearranged leukemic cells .

HY-122611R

CSRM617 (Standard)	Reference Standards Androgen Receptor Apoptosis	Cancer
CSRM617 (Standard) is the analytical standard of CSRM617. This product is intended for research and analytical applications. CSRM617 is a selective small-molecule inhibitor of the transcription factor ONECUT2 (OC2, a master regulator of androgen receptor) with a Kd of 7.43 uM in SPR assays, binding to OC2-HOX domain directly. CSRM617 induces apoptosis by appearance of cleaved Caspase-3 and PARP. CSRM617 is well tolerated in the prostate cancer mouse model

HY-N1486R

Ursonic acid (Standard) 3-Ketoursolic acid (Standard)	Reference Standards Apoptosis Endogenous Metabolite NF-κB	Inflammation/Immunology Cancer
CSRM617 (Standard) is the analytical standard of CSRM617. This product is intended for research and analytical applications. CSRM617 is a selective small-molecule inhibitor of the transcription factor ONECUT2 (OC2, a master regulator of androgen receptor) with a Kd of 7.43 uM in SPR assays, binding to OC2-HOX domain directly. CSRM617 induces apoptosis by appearance of cleaved Caspase-3 and PARP. CSRM617 is well tolerated in the prostate cancer mouse model

HY-156794A

Enzomenib enantiomer DSP-5336 enantiomer	Drug Isomer FLT3 Epigenetic Reader Domain	Cardiovascular Disease Cancer
Enzomenib enantiomer (DSP-5336 enantiomer) is an enantiomer of Enzomenib (HY-156794). Enzomenib (DSP-5336) is an orally active Menin inhibitor (IC₅₀=1.4 nM, K_d=6.0 nM). Enzomenib disrupts the interaction between Menin and KMT2A/MLL fusion proteins, specifically inhibits the expression of leukemia driver genes such as *HOX/MEIS1, and upregulates ITGAM. Enzomenib effectively induces cell differentiation, inhibits tumor cell proliferation, and suppresses primitive cell colony formation. Enzomenib reduces disease burden and prolongs survival, but causes adverse reactions including differentiation syndrome and QTc* interval prolongation. Enzomenib is used for research on relapsed/refractory acute myeloid leukemia, acute lymphoblastic leukemia, and other hematologic malignancies with mixed lineage leukemia (MLL) rearrangements or NPM1 mutations .

Cat. No.	Product Name	Target	Research Area

HY-P3245A

HXR9 hydrochloride	Apoptosis	Cancer
HXR9 hydrochloride is a cell-permeable peptide and a competitive antagonist of HOX/PBX interaction. HXR9 hydrochloride antagonizes the interaction between HOX and a second transcrip-tion factor (PBX), which binds to HOX proteins in paralogue groups1 to 8. HXR9 hydrochloride selectively decreases cell proliferation and promotes apoptosis in cells with a high level of expression of the HOXA/PBX3 genes, such as MLL-rearranged leukemic cells .

HY-P10948A

CS-VIP 8 hydrochloride	WDR5 Histone Methyltransferase	Cardiovascular Disease
CS-VIP 8 hydrochloride is a selective allosteric WDR5 protein inhibitor (K_i= 0.008 μM). CS-VIP 8 hydrochloride induces conformational changes in the MLL1 complex, leading to the dissociation of MLL1 from the complex, inhibiting MLL1 histone methyltransferase activity and regulating HOX gene expression. CS-VIP 8 hydrochloride is promising for research of hematological diseases such as leukemia .

HY-P10948

CS-VIP 8	WDR5 Histone Methyltransferase	Cardiovascular Disease
CS-VIP 8 is a selective allosteric WDR5 protein inhibitor (K_i= 0.008 μM). CS-VIP 8 induces conformational changes in the MLL1 complex, leading to the dissociation of MLL1 from the complex, inhibiting MLL1 histone methyltransferase activity and regulating HOX gene expression. CS-VIP 8 is promising for research of hematological diseases such as leukemia .

HY-P3245

HXR9	Apoptosis	Cancer
HXR9 is a cell-permeable peptide and a competitive antagonist of HOX/PBX interaction. HXR9 antagonizes the interaction between HOX and a second transcrip-tion factor (PBX), which binds to HOX proteins in paralogue groups1 to 8. HXR9 selectively decreases cell proliferation and promotes apoptosis in cells with a high level of expression of the HOXA/PBX3 genes, such as MLL-rearranged leukemic cells .

Ursonic acid (Standard) 3-Ketoursolic acid (Standard)	Triterpenes Structural Classification Terpenoids Plants Actaea simplex (DC.) Wormsk. ex Fisch. & C. A. Mey. Endogenous metabolite Rhamnaceae Source Classification	Reference Standards Apoptosis Endogenous Metabolite NF-κB
CSRM617 (Standard) is the analytical standard of CSRM617. This product is intended for research and analytical applications. CSRM617 is a selective small-molecule inhibitor of the transcription factor ONECUT2 (OC2, a master regulator of androgen receptor) with a Kd of 7.43 uM in SPR assays, binding to OC2-HOX domain directly. CSRM617 induces apoptosis by appearance of cleaved Caspase-3 and PARP. CSRM617 is well tolerated in the prostate cancer mouse model

Species:	Human (2)
Tag:	His (2)
Source:	E. coli (2)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P74879

	HOXA1 Protein, Human (His) Homeobox protein HOX-A1; HOXA1; HOX1F	Human	E. coli
	The HOXA1 protein is a sequence-specific transcription factor that complexly regulates multiple developmental processes in the brainstem, inner and outer ears, abducens nerves, and cardiovascular development. It also plays a key role in cognitive and behavioral processes. HOXA1 Protein, Human (His) is the recombinant human-derived HOXA1 protein, expressed by E. coli , with N-His labeled tag.

HY-P70308

	HOXB4 Protein, Human (His) rHuHomeobox protein B4-L175D, E176K, E178K, His; Homeobox Protein B4; Homeobox protein HOX-B4; Homeobox protein HOX-2.6; Homeobox protein HOX-2F; HOXB4; HOX2F	Human	E. coli
	HOXB4 protein, a sequence-specific transcription factor, critically participates in a developmental regulatory system, assigning specific positional identities to cells along the anterior-posterior axis. HOXB4 Protein, Human (His) is the recombinant human-derived HOXB4 protein, expressed by E. coli , with N-6*His labeled tag.

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Cat. No.
Species
Source
Tag
Accession
Gene ID
Molecular Weight
Purity
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Free Sample	Yes No
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Host:	Mouse (20) Rabbit (11)
Reactivity:	Human (31) Rat (18) Mouse (18)
Application:	IHC-P (19) ICC/IF (5) IF-Tissue (1) IP (3) WB (15) FC (3) ELISA (3)
Isotype:	IgG (11) IgG1 (10) IgG2a (4) IgG2b (6)
Conjugation:	Non-conjugated (31)
Clonality:	polyclonal (1) Monoclonal (19) Recombinant (9)
Modification:	Unmodified (21)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P88125

	HOXD10 Antibody (YA7809) HOX-4.4; HOX4; HOX4D; HOX4E	IHC-P	Human, Mouse, Rat
	HOXD10 Antibody (YA7809) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to HOXD10.

HY-P89095

	HOXD9 Antibody (YA8779) HOX-4.3; HOX-5.2; HOX4; HOX4C	IHC-P	Human
	HOXD9 Antibody (YA8779) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to HOXD9.

HY-P88125A

	HOXD10 Antibody (YA7809)(PBS only) HOX-4.4; HOX4; HOX4D; HOX4E	IHC-P	Human, Mouse, Rat
	HOXD10 Antibody (YA7809) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to HOXD10.

HY-P89095A

	HOXD9 Antibody (YA8779)(PBS only) HOX-4.3; HOX-5.2; HOX4; HOX4C	IHC-P	Human
	HOXD9 Antibody (YA8779) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to HOXD9.

HY-P88331

	HOXD8 Antibody (YA8015) HOX4; HOX4E; HOX5.4	IHC-P	Human, Mouse
	HOXD8 Antibody (YA8015) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to HOXD8.

HY-P89088

	HOXD4 Antibody (YA8772) HHO.C13; HOX-4.2; HOX-5.1; HOX4; HOX4B	IHC-P	Human, Mouse, Rat
	HOXD4 Antibody (YA8772) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to HOXD4.

HY-P83272

	HOXB9 Antibody (YA3017) Homeobox protein HOX-B9; HOX-2E; HOX-2.5; HOXB9; HOX2E	WB, ICC/IF, IP	Human
	HOXB9 Antibody (YA3017) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to HOXB9.

HY-P89088A

	HOXD4 Antibody (YA8772)(PBS only) HHO.C13; HOX-4.2; HOX-5.1; HOX4; HOX4B	IHC-P	Human, Mouse, Rat
	HOXD4 Antibody (YA8772) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to HOXD4.

HY-P83162

	HOXA5 Antibody (YA2907) HOX1; HOX1.3; HOX1C; HOXA5	WB	Human, Mouse, Rat
	HOXA5 Antibody (YA2907) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to HOXA5.

HY-P83164

	HOXA9 Antibody (YA2909) HOX1; ABD-B; HOX1G; HOX1.7	WB	Human
	HOXA9 Antibody (YA2909) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to HOXA9.

HY-P88331A

	HOXD8 Antibody (YA8015)(PBS only) HOX4; HOX4E; HOX5.4	IHC-P	Human, Mouse
	HOXD8 Antibody (YA8015) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to HOXD8.

HY-P82816

	HOXA13 Antibody (YA2561) Homeobox1J; HomeoboxA13; HOX 1; HOX 1J; HOX A13; HOX1; HOX1J; HOXA 13; HOXA13; Transcription factor HOXA13	WB	Human, Mouse, Rat
	HOXA13 Antibody (YA2561) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to HOXA13.

HY-P88180

	HOXA3 Antibody (YA7864) HOX1; HOX1E	WB	Human, Mouse, Rat
	HOXA3 Antibody (YA7864) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to HOXA3.

HY-P82942

	HOXB4 Antibody (YA2687) HOXB4; HOX2F; Homeobox protein HOX-B4; Homeobox protein HOX-2.6; Homeobox protein HOX-2F	WB, ICC/IF, IP	Human, Mouse, Rat
	HOXB4 Antibody (YA2687) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to HOXB4.

HY-P810449

	HOXA5 Antibody Homeobox protein HOX-A5, HOXA5, HOX1C, Homeobox protein HOX-1C	WB, IHC-P	Human, Rat
	HOXA5 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to HOXA5.

HY-P89096

	HOXC4 Antibody (YA8780) cp19; HOX3; HOX3E	IHC-P	Human, Mouse, Rat
	HOXC4 Antibody (YA8780) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to HOXC4.

HY-P88180A

	HOXA3 Antibody (YA7864)(PBS only) HOX1; HOX1E	WB	Human, Mouse, Rat
	HOXA3 Antibody (YA7864) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to HOXA3.

HY-P89096A

	HOXC4 Antibody (YA8780)(PBS only) cp19; HOX3; HOX3E	IHC-P	Human, Mouse, Rat
	HOXC4 Antibody (YA8780) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to HOXC4.

HY-P810365

	HOXA9 Antibody (YA9687) ABD-B, Abd-B, drosophila, homolog of, D6a9, Homeobox 1G, Homeobox A9, Homeobox protein HOX-1.7, Homeobox protein HOX-1G, Homeobox protein HOX-A9, Homeodomain protein HOXA9, HOX-1.7	WB, IHC-P	Human
	HOXA9 Antibody (YA9687) is a Rabbit-derived and non-conjugated IgG Recombinant,Monoclonal antibody, targeting to HOXA9.

HY-P88076

	HOXC10 Antibody (YA7760) HOX3I	IHC-P	Human, Mouse, Rat
	HOXC10 Antibody (YA7760) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to HOXC10.

HY-P88641

	HOXC11 Antibody (YA8325) HOX3H	IHC-P, ICC/IF, FC	Human, Mouse, Rat
	HOXC11 Antibody (YA8325) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to HOXC11.

HY-P85285

	MSX1 Antibody (YA4977) MSX1; HOX7; Homeobox protein MSX-1; Homeobox protein HOX-7; Msh homeobox 1-like protein	WB	Human
	MSX1 Antibody (YA4977) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to MSX1.

HY-P88076A

	HOXC10 Antibody (YA7760)(PBS only) HOX3I	IHC-P	Human, Mouse, Rat
	HOXC10 Antibody (YA7760) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to HOXC10.

HY-P88641A

	HOXC11 Antibody (YA8325)(PBS only) HOX3H	IHC-P, ICC/IF, FC	Human, Mouse, Rat
	HOXC11 Antibody (YA8325) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to HOXC11.

HY-P81453

	HOXB13 Antibody (YA1198) HOXB13; Homeobox protein HOX-B13	IHC-P	Human
	HOXB13 Antibody (YA1198) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to HOXB13.

HY-P810340

	HOXB13 Antibody (YA9662) Homeobox protein HOX-B13, HOXB13	WB, ICC/IF, IF-Tissue, IHC-P, IP, ELISA	Human
	HOXB13 Antibody (YA9662) is a Mouse-derived and non-conjugated IgG1 Monoclonal antibody, targeting to HOXB13.

HY-P84234

	MSX1 Antibody (YA3931) HOX7; HYD1; STHAG1; MSX1	WB, ELISA	Human
	MSX1 Antibody (YA3931) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to MSX1.

HY-P81453A

	HOXB13 Antibody (YA1198)(PBS only) HOXB13; Homeobox protein HOX-B13	IHC-P	Human
	HOXB13 Antibody (YA1198) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to HOXB13.

HY-P84234A

	MSX1 Antibody (YA3931)(PBS only) HOX7; HYD1; STHAG1; MSX1	WB, ELISA	Human
	MSX1 Antibody (YA3931) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to MSX1.

HY-P86905

	HOXC6 Antibody (YA6598) CP25 antibody; HHO.C8 antibody; Homeo box 3C antibody; Homeo box C6 antibody; Homeo box C8 protein antibody; Homeobox C6 antibody; Homeobox protein CP25 antibody; Homeobox protein HHO.C8 antibody; Homeobox protein HOX-3C antibody; Homeobox protein HOX-C6 antibody; CP25 antibody; HHO.C8 antibody; Homeo box 3C antibody; Homeo box C6 antibody; Homeo box C8 protein antibody; Homeobox C6 antibody; Homeobox protein CP25 antibody; Homeobox protein HHO.C8 antibody; Homeobox protein HOX-3C antibody; Homeobox protein HOX-C6 antibody; HOX3 antibody; HOX3C antibody; HOXc6 antibody; HXC6_HUMAN antibody;	WB	Human, Rat
	HOXC6 Antibody (YA6598) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to HOXC6.

HY-P83045

	CHX10 Antibody (YA2790) CHX 10; HOX10; MCOP2; MCOPCB3; RET1; Vsx2	WB, FC	Human, Mouse, Rat
	CHX10 Antibody (YA2790) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CHX10.

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HOX

Inhibitors & Agonists

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