Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
5 Results for "
HRASLS
" in MedChemExpress (MCE) Product Catalog:
Products (5)
5 Results for "HRASLS" in MCE Product Catalog:
1
1 Cited Publications
Target:
Research Areas:
LEI110 is a pan-inhibitor of the HRASLS family and an inhibitor of AP-2α, with a Ki of 20 nM against PLA2G16. LEI110 exhibits inhibitory activity against PLA2G16, HRASLS2, RARRES3 and iNAT, with pIC50 values of 7.0, 6.8, 6.8 and 7.6, respectively. LEI110 binds to the active site of PLA2G16, reduces intracellular arachidonic acid levels, and attenuates oleic acid-induced lipolysis. LEI110 stabilizes AP-2α, impairs its DNA-binding ability, inhibits the transcription of DNA damage repair genes, induces the accumulation of oxidative DNA damage, suppresses cell proliferation and clonogenicity, and sensitizes HCC cells to DNA-damaging agents. LEI110 can be used in research related to obesity, fatty liver disease, the common cold and hepatocellular carcinoma .
Cat. No.: HY-RS10637
Target:
Research Areas:
PLAAT1 Human Pre-designed siRNA Set A contains three designed siRNAs for PLAAT1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P88430A
Synonyms: AdPLA; H-REV107-1; HRASLS3; HREV107; HREV107-1; HREV107-3; HRSL3
Cat. No.: HY-P71211
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PLAAT3; H-Rev 107 Protein Homolog; Prev. HRASLS3; Adipose-Specific PLA2; Prev. PLA2G16; MGC118754.; HREV107-3; HREV107-1; HREV107; H-REV107; AdPLA; HRSL3; HRAS-Like Suppressor 3; Phospholipase A/Acyltransferase‐3; H-REV107-1; Ca-Independent Phospholipase
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
