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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
9 Results for "
HVA
" in MedChemExpress (MCE) Product Catalog:
Products (9)
9 Results for "HVA" in MCE Product Catalog:
Research Areas:
MRGPRX1 agonist 1 is a highly potent MRGPRX1 agonist (EC50=50 nM) with greater than 50-fold selectivity for δ, μ, and κ opioid receptors. MRGPRX1 agonist 1 is inactive against MRGPRC11. MRGPRC11 inhibits high voltage-activated (HVA) Ca 2+ currents, reduces neurotransmitter release, and mitigates nociceptive transmission in the spinal cord. MRGPRX1 agonist 1 is useful for the study of chronic pain, especially neuropathic pain .
Cat. No.: HY-16677A
CAS No.: 120635-25-8
Synonyms: MDL72974A
Target:
Research Areas:
Mofegiline hydrochloride (MDL-72974A) is an orally active and blood-brain barrier-penetrant MAO-B/SSAO selective inhibitor, with an IC50 of 3.6 nM for MAO-B and 10 nM for SSAO. Mofegiline hydrochloride is a cationic amphiphilic compound that can induce indirect sympathomimetic effects, lysosomal accumulation, hERG channel interactions, phospholipidosis, and cell death. Mofegiline hydrochloride protects mice from MPTP-induced depletion of striatal dopamine, DOPAC, and HVA. Mofegiline hydrochloride can be used in research related to Parkinson's disease .
Research Areas:
Ro 41-0960 is a CNS-penetrant, orally active catechol-O-methyl transferase (COMT) inhibitor. Ro 41-0960 reduces dopamine catabolism, increases striatal dopamine and DOPAC levels, decreases striatal HVA levels, induces apoptosis, inhibits proliferation and extracellular matrix formation in uterine fibroid cells. Ro 41-0960 arrests or shrinks uterine fibroid lesions in rats. Ro 41-0960 can be used for the research of Parkinson’s disease, uterine leiomyomas, and breast cancer .
Cat. No.: HY-W002110
CAS No.: 1131-94-8
Synonyms: 3-Hydroxy-4-methoxyphenylacetic acid; iso-HVA; Homoisovanillic acid
Category:
Monophenols Ketones, Aldehydes, Acids Phenols Endogenous metabolite Disease Research Fields Cancer
Target:
Target:
Cat. No.: HY-W002110R
CAS No.: 1131-94-8
Synonyms: 3-Hydroxy-4-methoxyphenylacetic acid (Standard); iso-HVA (Standard); Homoisovanillic acid (Standard)
Target:
Cat. No.: HY-19061
CAS No.: 111757-17-6
Target:
Research Areas:
CGP 28014 is a catechol-O-methyltransferase inhibitor. CGP 28014 can lower HVA levels and increase DOPAC levels in the striatum of rats, making it useful for research on Parkinson's disease .
Synonyms: (-)-Linalool (Standard)
Cat. No.: HY-16677
CAS No.: 119386-96-8
Synonyms: MDL-72974
Target:
Research Areas:
Mofegiline (MDL-72974) is an orally active and blood-brain barrier-penetrant MAO-B/SSAO selective inhibitor, with an IC50 of 3.6 nM for MAO-B and 10 nM for SSAO. Mofegiline is a cationic amphiphilic compound that can induce indirect sympathomimetic effects, lysosomal accumulation, hERG channel interactions, phospholipidosis, and cell death. Mofegiline protects mice from MPTP-induced depletion of striatal dopamine, DOPAC, and HVA. Mofegiline can be used in research related to Parkinson's disease .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
