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Hericium erinaceum

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (1) Bacterial (1) Bcl-2 Family (1) Caspase (1) Drug Derivative (1) Glycosidase (1) Histone Acetyltransferase (1) JNK (1) NF-κB (1) NO Synthase (1) p38 MAPK (1)
By Research Areas:	Cancer (2) Infection (1) Inflammation/Immunology (1) Neurological Disease (2)

Inhibitors & Agonists

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-111954

(+)-Erinacin A Erinacine A	Apoptosis JNK NF-κB Histone Acetyltransferase NO Synthase Bcl-2 Family p38 MAPK Caspase	Neurological Disease Inflammation/Immunology Cancer
(+)-Erinacin A (Erinacine A) is a cyanoditerpenoid isolated from Hericium erinaceus with anticancer, anti-inflammatory and neuroprotective activities. (+)-Erinacin A can induce cancer cell death by activating extrinsic and intrinsic apoptosis pathways. (+)-Erinacin A can also inhibit the expression of NO synthase (iNOS) and the production of nitrotyrosine to exert inflammatory and neuroprotective effects, thereby reducing ischemic brain damage .

HY-N11019

Erinacine P 1 Publications Verification	Bacterial	Infection
Erinacine P is a cyathane-type diterpenoid antibacterial agent. Erinacine P is isolated from the biosynthesis of mycelia and submerged cultures of Hericium erinaceum. Erinacine P serves as a precursor for the production of important active components such as Erinacine C, A and B. Erinacine P exhibits significant antibacterial activity against Aliivibrio fischeri .

HY-N12566

Erinacin B	Others	Neurological Disease
Erinacin B is a active product that can be extracts from the mycelia of Hericium erinaceum. Erinacin B shows potent stimulating activity of nerve growth factor (NGF)-synthesis .

HY-N15387

Hericenone J	Drug Derivative	Cancer
Hericenone J (Compound 6) is an aromatic compound with anticancer activity, which is found in Hericium erinaceum. Hericenone J is cytotoxic and can significantly reduce the viability of HL-60 human acute promyelocytic leukemia cells with an IC₅₀ value of 4.13 μM. Hericenone J is promising for research of leukemia .

HY-N8409

FD-838	Others	Others
FD-838 is a Alkaloids product that can be isolated from the mycelia of the basidiomycete Hericium erinaceum. .

HY-W754452

Hericenone E	Others	Others
Hericenone E is an aromatic compound that can be found in Hericium erinaceum. Hericenone E exhibits moderate cytotoxicity .

HY-N3104

Paxiphylline E Daphnilongeranine A N-oxide	Others	Others
Paxiphylline E (Daphnilongeranine A N-oxide) is a Alkaloids product that can be isolated from the mycelia of the basidiomycete Hericium erinaceum. .

HY-N18381

Deacylhericene	Glycosidase	Others
Deacylhericene is an α-glucosidase inhibitor with an IC₅₀ of 12.5 μM. Deacylhericene functionally inhibits the activity of α-glucosidase .

(+)-Erinacin A Erinacine A	Microorganisms Terpenoids Diterpenoids	Apoptosis JNK NF-κB Histone Acetyltransferase NO Synthase Bcl-2 Family p38 MAPK Caspase
(+)-Erinacin A (Erinacine A) is a cyanoditerpenoid isolated from Hericium erinaceus with anticancer, anti-inflammatory and neuroprotective activities. (+)-Erinacin A can induce cancer cell death by activating extrinsic and intrinsic apoptosis pathways. (+)-Erinacin A can also inhibit the expression of NO synthase (iNOS) and the production of nitrotyrosine to exert inflammatory and neuroprotective effects, thereby reducing ischemic brain damage .

Erinacine P 1 Publications Verification	Structural Classification Hericium erinaceus (Bull.) Pers. Human Gut Microbiota Metabolites Microorganisms Terpenoids Diterpenoids Endogenous metabolite Source Classification	Bacterial
Erinacine P is a cyathane-type diterpenoid antibacterial agent. Erinacine P is isolated from the biosynthesis of mycelia and submerged cultures of Hericium erinaceum. Erinacine P serves as a precursor for the production of important active components such as Erinacine C, A and B. Erinacine P exhibits significant antibacterial activity against Aliivibrio fischeri .

Erinacin B	Microorganisms Terpenoids Diterpenoids Source Classification	Others
Erinacin B is a active product that can be extracts from the mycelia of Hericium erinaceum. Erinacin B shows potent stimulating activity of nerve growth factor (NGF)-synthesis .

Hericenone J	Monophenols Microorganisms Phenols Source Classification	Drug Derivative
Hericenone J (Compound 6) is an aromatic compound with anticancer activity, which is found in Hericium erinaceum. Hericenone J is cytotoxic and can significantly reduce the viability of HL-60 human acute promyelocytic leukemia cells with an IC₅₀ value of 4.13 μM. Hericenone J is promising for research of leukemia .

FD-838	Alkaloids Microorganisms Other Alkaloids Source Classification	Others
FD-838 is a Alkaloids product that can be isolated from the mycelia of the basidiomycete Hericium erinaceum. .

Hericenone E	Structural Classification Microorganisms Simple Phenylpropanols Phenylpropanoids Source Classification	Others
Hericenone E is an aromatic compound that can be found in Hericium erinaceum. Hericenone E exhibits moderate cytotoxicity .

Paxiphylline E Daphnilongeranine A N-oxide	Daphniphyllum paxianum K. Rosenth. Alkaloids Pyrrole Alkaloids Plants Source Classification	Others
Paxiphylline E (Daphnilongeranine A N-oxide) is a Alkaloids product that can be isolated from the mycelia of the basidiomycete Hericium erinaceum. .

Deacylhericene	Structural Classification Microorganisms Simple Phenylpropanols Phenylpropanoids Source Classification	Glycosidase
Deacylhericene is an α-glucosidase inhibitor with an IC₅₀ of 12.5 μM. Deacylhericene functionally inhibits the activity of α-glucosidase .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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Hericium erinaceum

Inhibitors & Agonists

NaturalProducts

Natural
Products