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Pathways Recommended: Metabolic Enzyme/Protease
Results for "

Homo sapiens caseinolytic protease P

" in MedChemExpress (MCE) Product Catalog:
Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-163319
    NCA029

    		ClpP Apoptosis Cancer
    NCA029 is a potent and selective homo sapiens caseinolytic protease P (HsClpP) activator with an EC50 of 0.15 μM. NCA029 acts on HsClpP to activate an ATF3-dependent integrative stress response, leading to colon cancer cell death .
    NCA029
  • HY-152096
    (R)-ZG197

    		ClpP Bacterial Infection
    (R)-ZG197 is a highly selective Staphylococcus aureus Caseinolytic protease P (SaClpP) activator with an EC50 of 1.5 μM. (R)-ZG197 also activates Homo sapiens ClpP (HsClpP) with an EC50 of 31.4 μM .
    (R)-ZG197
  • HY-181934
    ClpP activator-2

    		ClpP Reactive Oxygen Species (ROS) Mitochondrial Metabolism Cancer
    ClpP activator-2 (Compound GU18) is a ClpP activator with a Kd of 5.01 μM for HsClpP. ClpP activator-2 enhances the proteolytic activity of HsClpP and promotes the degradation of α-casein by HsClpP, with an EC50 of 1.09 μM. ClpP activator-2 induces the accumulation of mitochondrial reactive oxygen species (ROS), leading to damage to mitochondrial structure and function. ClpP activator-2 exhibits significant in vivo anti-multiple myeloma activity .
    ClpP activator-2

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