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Results for "

IA

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Payload (1) Adrenergic Receptor (1) Akt (1) Aminoacyl-tRNA Synthetase (1) Amyloid-β (1) Antibiotic (5) AP-1 (1) Apoptosis (3) Autophagy (1) Bacterial (14) Biochemical Assay Reagents (6) Casein Kinase (1) CDK (1) Cholinesterase (ChE) (2) COX (1) Cytochrome P450 (2) Drug Derivative (5) Drug Metabolite (2) EGFR (2) Endogenous Metabolite (2) ERK (1) Estrogen Receptor/ERR (1) Fungal (1) GABA Receptor (2) Glucocorticoid Receptor (2) Glucose-6-Phosphate Isomerase (GPI) (1) Histamine Receptor (1) HIV Protease (4) Interleukin Related (5) IRE1 (1) Isotope-Labeled Compounds (3) Kinesin (1) Lipase (1) MAP4K (1) MHC (2) Microtubule/Tubulin (1) Mitosis (1) Monoamine Oxidase (1) mRNA (1) NF-κB (2) NO Synthase (3) PCSK9 (1) PGE synthase (1) Phosphatase (1) Phosphomannose Isomerase (PMI) (2) PI3K (1) Potassium Channel (9) Reactive Oxygen Species (ROS) (1) Reference Standards (9) Sodium Channel (5) TNF Receptor (4) TREM receptor (2) TRP Channel (1)
By Research Areas:	Cancer (23) Cardiovascular Disease (11) Endocrinology (3) Infection (21) Inflammation/Immunology (18) Metabolic Disease (15) Neurological Disease (3)
Click Chemistry:	Alkynes (1)
Oligonucleotides:	Pegylated Lipids (1) mRNA (1)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-107204

Furafylline 2 Publications Verification	Cytochrome P450	Cancer
Furafylline is a potent and selective inhibitor of human cytochrome P450IA2 with an IC₅₀ of 0.07 μM.

HY-P10136

IA9 2 Publications Verification human TREM-2 182-190	TREM receptor	Inflammation/Immunology
IA9 (human TREM-2 182-190) is a potent, CNS-penetrant TREM-2 inhibitor. IA9 can diminish the release of proinflammatory cytokines and suppress joint inflammation and damage in a Collagen (HY-P5003)-induced arthritis (CIA) mouse model. IA9 can be used for neuroinflammation PET imaging. IA9 can be used for Rheumatoid arthritis (RA) and neuroinflammation research .

HY-136205

IA-Alkyne 4 Publications Verification Iodoacetamide-alkyne; N-Hex-5-ynyl-2-iodo-acetamide	TRP Channel	Infection Inflammation/Immunology
IA-Alkyne (Iodoacetamide-alkyne; N-Hex-5-ynyl-2-iodo-acetamide) is a TRP channel (TRPC) agonist and has the potential for the study of respiratory infection . IA-Alkyne can be used to develop an isotopically tagged probe for quantitative cysteine-reactivity profiling . IA-Alkyne is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-N0554

Escin IA 1 Publications Verification	HIV Protease Monoamine Oxidase	Infection Inflammation/Immunology Cancer
Escin IA is an oral LOXL2 inhibitor and EMT inhibitor, with selectivity for LOXL2-expressing cells. Escin IA suppresses invasion, migration, and metastasis of breast cancer cells, and acts as the primary anti-TNBC metastasis constituent of Aesculus chinensis Bunge fruit saponin fraction. Escin IA can be used for the research of triple-negative breast cancer, acute inflammation, and ethanol-induced gastric mucosal lesions .

HY-12533

Disopyramide 2 Publications Verification Dicorantil; SC-7031	Sodium Channel Potassium Channel	Cardiovascular Disease
Disopyramide (Dicorantil) is a class IA antiarrhythmic agent with efficacy in ventricular and atrial arrhythmias. Disopyramide blocks the fast inward sodium current of cardiac muscle and prolongs the duration of cardiac action potentials. Disopyramide inhibits HERG encoded potassium channels. Disopyramide also exhibits complex protein binding, and has a potent negative inotropic action .

HY-163102

IA-14069	TNF Receptor NF-κB	Inflammation/Immunology
IA-14069 is an orally active tumor necrosis factor-α (TNF-α) inhibitor. IA-14069 binds directly to TNF-α and TNF-α-triggered signaling (p-IκBα and NF-κB p65) activities. Additionally, IA-14069 exerts a suppressive effect on Dextran sodium sulfate (HY-116282C) (DSS)-induced colitis. IA-14069 can be used for the research of Rheumatoid arthritis (RA) and inflammatory bowel disease (IBD) .

HY-108738

Daclizumab Ro 24-7375	Interleukin Related Apoptosis	Inflammation/Immunology Cancer
Daclizumab (Ro 24-7375) is a humanized, monoclonal antibody that blocks CD25 (α-subunit of the high-affinity interleukin-2 receptor (IL-2R-HA)). Daclizumab inhibits effector T cell activation, regulatory T cell (Treg) expansion and survival, and activation-induced T-cell apoptosis. Daclizumab increases IL-2 bioavailability to bind to the intermediate-affinity IL-2R (IL-2R-IA), driving the expansion of anti-inflammatory CD56bright natural killer (NK) cells. Daclizumab can be used for multiple sclerosis and cancer research .

HY-A0279A

Pristinamycin IA 1 Publications Verification Mikamycin B; Mikamycin IA	Bacterial Antibiotic	Infection
Pristinamycin IA (Mikamycin B) is a cycle-peptidic macrolactone antibiotic. Pristinamycin IA is a substrate of P-glycoprotein and inhibits its function. Pristinamycin IA is active against StaphyloEoccus and Srreptococcus .

HY-12533A

Disopyramide phosphate 2 Publications Verification Dicorantil phosphate; SC-7031 phosphate	Potassium Channel Sodium Channel	Cardiovascular Disease
Disopyramide phosphate is a class IA antiarrhythmic agent with efficacy in ventricular and atrial arrhythmias. Disopyramide phosphate blocks the fast inward sodium current of cardiac muscle and prolongs the duration of cardiac action potentials. Disopyramide phosphate inhibits HERG encoded potassium channels. Disopyramide phosphate also exhibits complex protein binding, and has a potent negative inotropic action .

HY-P10136A

IA9 TFA 2 Publications Verification human TREM-2 182-190 TFA	TREM receptor	Inflammation/Immunology
IA9 TFA (human TREM-2 182-190 TFA) is a potent, CNS-penetrant TREM-2 inhibitor. IA9 TFA can diminish the release of proinflammatory cytokines and suppress joint inflammation and damage in a Collagen (HY-P5003)-induced arthritis (CIA) mouse model. IA9 TFA can be used for neuroinflammation PET imaging. IA9 TFA can be used for Rheumatoid arthritis (RA) and neuroinflammation research .

HY-116622

α5IA L-822179	GABA Receptor	Neurological Disease
α5IA (L-822179) is a selective α5 GABAA receptor inverse agonist with neuroprotective potential .

HY-B1197

Amcinonide CL-34699	Glucocorticoid Receptor NO Synthase Interleukin Related TNF Receptor	Inflammation/Immunology Endocrinology
Amcinonide is an inhibitor of NO release (IC₅₀ = 3.38 nM). Amcinonide inhibits NNC-induced expression of the proinflammatory genes iNOS, TNF-α, and IL-1β in glial cells. Amcinonide reduces the numbers of T6+/Ia+ cells with a concomitant increase in T6+/Ia- cells. Amcinonide induces a selective reduction in expression of Ia antigens. Amcinonide can also be studied in research for eczematous dermatitis .

HY-NP005

Avidin, chiken egg white	Biochemical Assay Reagents	Inflammation/Immunology
Avidin, chicken egg white is a glycoprotein derived from egg protein. Avidin, chicken egg white has excellent affinity with biotin and is often used in combination with biotin for immunoassays to detect the location of antigens in tissues .

HY-143205

Desthiobiotin polyethyleneoxide iodoacetamide 1 Publications Verification IA-DTB	Biochemical Assay Reagents	Cancer
Desthiobiotin polyethyleneoxide iodoacetamide is useful for cysteine labeling in chemoproteomic experiments .

HY-N1474

Picfeltarraenin IA	Cholinesterase (ChE)	Infection Inflammation/Immunology Cancer
Picfeltarraenin IA, a triterpenoid obtained from Picriafel-terrae Lour (P.fel-terrae), is an acetylcholinesterase (AChE) inhibitor. Picfeltarraenin IA can be used for the treatment of herpes infections, cancer and inflammation .

HY-P1047

β-Sheet Breaker Peptide iAβ5 [Pro18, Asp21] β-Amyloid (17-21)	Amyloid-β	Neurological Disease
β-Sheet Breaker Peptide iAβ5 is an effective brain amyloid-β (Abeta) degrader. Abeta deposits are associated with Alzheimer's disease (AD), and the related toxicity arises from its β-sheet conformation and aggregation. β-Sheet Breaker Peptide iAβ5 can repeatedly induce the degradation of fibrillary amyloid deposits in vivo. Therefore, β-Sheet Breaker Peptide iAβ5 can prevent and/or reverse neuronal contraction caused by Abeta and reduce the range of interleukin IL-1beta positive microglial-like cells around Abeta deposits. β-Sheet Breaker Peptide iAβ5 can reduce the size and/or number of brain amyloid plaques in AD. β-Sheet Breaker Peptide iAβ5 is labeled with a hydrophobic benzyl alcohol (HBA) tag and shows a bright blue color under acidic conditions, which can be used for quantitative determination.

HY-171036

GAPDH-IN-1	Endogenous Metabolite	Metabolic Disease
GAPDH-IN-1 (Compound F8) is a GAPDH inhibitor (IC₅₀ of 39.31 μM for GAPDH enzymatic activity). GAPDH-IN-1 forms a covalent adduct with an aspartic acid in the active site to displace NAD ⁺, a cofactor of the enzyme, with concomitant enhancement of the cysteine-reactive probe reaction with the catalytic cysteine .

HY-138802

ML089 1 Publications Verification	Phosphomannose Isomerase (PMI)	Metabolic Disease
ML089 is a potent, selective, and orally available phosphomannose isomerase (PMI) inhibitor with an IC₅₀ of 1.3 µM. ML089 can be used for the research of congenital disorder of glycosylation Ia .

HY-106577

Cibenzoline Cifenline; Ro 22-7796	Potassium Channel	Cardiovascular Disease Metabolic Disease
Cibenzoline is a class Ia antiarrhythmic active molecule with low anticholinergic activity. Cibenzoline is a K_ATP channel inhibitor, acting through the pore forming subunit Kir6.2, with an IC₅₀ of 22.2 μM. Cibenzoline inhibits I_Kr and I_Ks currents with IC₅₀ values of 8.8 μM and 12.3 μM, respectively. Cibenzoline is used in the study of cardiac diseases. In addition, Cibenzoline can induce hypoglycemia .

HY-N0556

Isoescin IA	HIV Protease	Infection
Isoescin IA is a triterpenoid saponin isolated from the seeds of Aesculus chinensis. Isoescin IA has anti-HIV-1 protease activity .

HY-P990188

*Anti-Mouse MHC class II (I-A) Antibody (Y-3P)*	MHC	Inflammation/Immunology
Anti-Mouse MHC class II (I-A) Antibody (Y-3P) is a mouse-derived IgG2a κ type antibody inhibitor, targeting to mouse MHC class II. Anti-Mouse MHC class II (I-A) Antibody (Y-3P) reacts with mouse MHC Class II haplotypes I-Ab, I-Af, I-Ap, I-Aq, I-Ar, I-As, I-Au, I-Av, and weakly with I-Ak. Anti-Mouse MHC class II (I-A) Antibody (Y-3P) blocks MHC class II and inhibits expansion of regulate T cells. Anti-Mouse MHC class II (I-A) Antibody (Y-3P) can be used for the immunology research .

HY-112861A

Gln-AMS TFA 3 Publications Verification	Aminoacyl-tRNA Synthetase Bacterial	Infection
Gln-AMS (TFA) is a type Ia aminoacyl-tRNA synthetase (AARS) inhibitor. Gln-AMS inhibits glutaminyl-tRNA synthetase (GlnRS) with a K_i of 1.32 µM.

HY-124890

Thr101	Phosphomannose Isomerase (PMI) Glucose-6-Phosphate Isomerase (GPI)	Metabolic Disease
Thr101 is an inhibitor (IC₅₀=2.9 μM) of phosphomannose isomerase (PMI).PMI can compete with phosphomannose mutase 2 (PMM2) for the binding site of Man-6-P and convert mannose-6-phosphate (Man-6-P) into fructose-6-phosphate (Fru-6-P) .Thr101 only specifically inhibits PMI and not PMM2. Thr101 can be used for research of congenital disorder of glycosylation type Ia (CDG-Ia) .

HY-178946

IA107	IRE1	Cancer
IA107 is a potent, selective, and allosteric IRE1α RNase (IC₅₀ = 16 nM (non phosphorylated), IC₅₀ = 9 nM (phosphorylated)) inhibitor. IA107 can inhibit endoplasmic reticulum stress-induced XBP1 mRNA splicing and protein expression, and has no cytotoxicity .

HY-111560

IQM-266	Potassium Channel	Neurological Disease
IQM-266 is a Downstream Regulatory Element Antagonist Modulator (DREAM) ligand with a K_D of 4.63 μM. IQM-266 inhibits the K_V4.3/DREAM current in a concentration-, voltage-, and time-dependent-manner. IQM-266 also modulates A-type outward potassium currents (IA) from rat dorsal root ganglia (DRG) neurons. IQM-266 can be used for neurological disease research, such as Alzheimer’s disease and Huntington's disease (HD) .

HY-N11070

23-Epi-26-deoxycimicifugoside	Others	Others
23-Epi-26-deoxycimicifugoside ia a triterpene xyloside that can be isolated from Cimicifuga racemosa .

HY-111378

Casein Kinase II Inhibitor IV	Casein Kinase	Metabolic Disease
Casein Kinase II Inhibitor IV is a potent, ATP-competitive of casein kinase II inhibitor with an IC₅₀ of 9 nM. Casein Kinase II Inhibitor IV ia also a human keratinocytes (NHEK) differentiation inducer .

HY-19829

Sandramycin	ADC Payload Bacterial Antibiotic	Infection Cancer
Sandramycin ia a cyclic depsipeptide antibiotic isolated from cultured broth of a Nocardioides sp. Sandramycin is also a DNA intercalator that potently binds DNA and is an ADC cytotoxin. Sandramycin is active against Gram-positive bacteria and has potent antitumor activity .

HY-N0556R

Isoescin IA (Standard)	Reference Standards HIV Protease	Infection
Isoescin IA (Standard) is the analytical standard of Isoescin IA. This product is intended for research and analytical applications. Isoescin IA is a triterpenoid saponin isolated from the seeds of Aesculus chinensis. Isoescin IA has anti-HIV-1 protease activity .

HY-124790

KSP-IA	Kinesin Mitosis	Cancer
KSP-IA (compound 17) is a potent kinesin spindle protein (KSP) inhibitor with an IC₅₀ value of 3.6 nM. KSP-IA inhibits cell mitosis .

HY-N0554R

Escin IA (Standard)	Reference Standards HIV Protease	Infection Cancer
Escin IA (Standard) is the analytical standard of Escin IA. This product is intended for research and analytical applications. Escin IA is a triterpene saponin isolated from Aesculus hippocastanum, which inhibits HIV-1 protease with IC50 values of 35 μM. Escin IA has anti-TNBC metastasis activity, and its action mechanisms involved inhibition of epithelial-mesenchymal transition process by down-regulating LOXL2 expression .

HY-121076

Berteroin	Bacterial	Infection Inflammation/Immunology Cancer
Berteroin, a naturally occurring Sulforaphane analog, ia an antimetastatic agent. Berteroin has anti-inflammatory, antitumor and bactericidal effects .

HY-P10159

DJK-5	Bacterial	Infection
Diplacol ia a natural compound from from Mimulus clevelandi and shows potent inhibitory activities against lipopolysaccharide (LPS)-induced nitric oxide production .

HY-A0279AR

Pristinamycin IA (Standard) Mikamycin B (Standard); Mikamycin IA (Standard)	Reference Standards Bacterial Antibiotic	Infection
Pristinamycin IA (Standard) is the analytical standard of Pristinamycin IA. This product is intended for research and analytical applications. Pristinamycin IA (Mikamycin B) is a cycle-peptidic macrolactone antibiotic. Pristinamycin IA is a substrate of P-glycoprotein and inhibits its function. Pristinamycin IA is active against StaphyloEoccus and Srreptococcus[1].

HY-N1474R

Picfeltarraenin IA (Standard)	Reference Standards Cholinesterase (ChE) Interleukin Related PGE synthase NF-κB COX	Inflammation/Immunology
Picfeltarraenin IA (Standard) is the analytical standard of Picfeltarraenin IA (HY-N1474). This product is intended for research and analytical applications. Picfeltarraenin IA is an Acetylcholinesterase inhibitor. Picfeltarraenin IA can be extracted from the plant Picria fel-terrae Lour. Picfeltarraenin IA reduces the production of IL-8 and PGE2. Picfeltarraenin IA inhibits COX2 via the NF-κB pathway. Picfeltarraenin IA can be used in the research of respiratory system diseases .

HY-N7576

Anemarrhenasaponin Ia	Others	Cardiovascular Disease
Anemarrhenasaponin Ia is a steroidal saponin that can be isolated from the rhizomes of Anemarrhena asphodeloides Bunge. Anemarrhenasaponin Ia inhibits platelet aggregation. Anemarrhenasaponin Ia induces mild concentration-dependent hemolysis. Anemarrhenasaponin Ia inhibits fMLP- and AA-induced superoxide anion production, while enhancing PMA-induced superoxide anion production. Anemarrhenasaponin Ia can be used in studies related to thrombosis .

HY-N14877

Enactin Ia	Fungal	Infection
Enactin Ia is found in the strain of Streptomyces roseoviridis. Enactin Ia has only weak antifungal activity.

HY-N15226

Butyrolactone Ia	NO Synthase Interleukin Related Autophagy	Inflammation/Immunology
Butyrolactone Ia is the inhibitor for the NO production with an IC₅₀ of 18 μM. Butyrolactone Ia inhibits LPS (HY-D1056)-induced mRNA expression of iNOS and the inflammatory cytokine IL-1β. Butyrolactone Ia modulates autophagy in HeLa cells, and exhibits immune suppressive activity .

HY-156029

IA1-8H2	Phosphatase	Cancer
IA1-8H2 is a non-covalent, non-competitive inhibitor of PHPT1 (IC₅₀: 3.4 μM). IA1-8H2 can be used for research of lung cancer, hepatocarcinoma, and renal cancer .

HY-N13692

Cinchonain Ia	Others	Others
Cinchonain Ia is a natural product .

HY-P5721

Apidaecin IA	Bacterial	Infection
Apidaecin IA is an antibacterial peptide that can be found in honeybees .

HY-N13082

Deacetylescin Ia	Others	Metabolic Disease
Deacetylescin Ia (compound 12) is a deacetylated compound with anti-hyperglycemic effects that can be extracted from the debittered Aesculus and deacetylated at the C-22 position. Deacetylescin Ia (100 mg/kg) can inhibit blood glucose elevation in mouse glucose tolerance tests .

HY-N8500

Aristolochic acid Ia	Drug Metabolite	Others
Aristolochic acid Ia is an oxidative metabolite of aristolochic acid I, which can be used to study the detoxification pathway of aristolochic acid metabolism .

HY-N6854A

3α-Hydroxymogroside IA1	Drug Derivative	Metabolic Disease Cancer
3α-Hydroxymogroside IA1 is a mogroside derivative.

HY-W441003

DSPE-PEG2000-IA	Biochemical Assay Reagents	Others
DSPE-PEG2000-IA is a thiol reactive phospholipid polyPEG. The iodoacetyll group is reactive with thiol to produce a thioether linkage. The polymer can self-assemble in water to form lipid bilayer and can be used to encapsulate drugs in targeted delivery application, such as liposomal doxorubicin as an anti cancer drug or mRNA vaccine.

HY-W440902

DSPE-PEG3400-IA	Biochemical Assay Reagents	Others
DSPE-PEG3400-IA is an iodoacetyll PEG lipid. The polymer can form lipid bilayer or micelles spontaneoulsy in water. The lipophilic tails can be used to encapsulate hydrophobic therapeutic agents while the hydrophilic head can be used to encapuslate hydrophilic drugs/nutrient, such as antibody, mRNA/DNA. The iodoacetyl group is reactive with thiol to produce a thioether linkage.

HY-W440903

DSPE-PEG5000-IA	Biochemical Assay Reagents	Others
DSPE-PEG5000-IA is a cyclooctyne containing phospholipid PEG polymer. The polymer can self-assemble spontaneously in water to form micelles/lipid bilayer. It can be used to prepare nanoparticles or liposomes as drug carrier in targeted drug delivery system. The DBCO can react with azide molecule via copper free click chemistry to form a stable triazole bond.

HY-163970

*Heparin disaccharide I-A* sodium**	Biochemical Assay Reagents	Others
Heparin disaccharide I-A (sodium)is a class of biochemical reagents used in glycobiology research. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It involves carbohydrate chemistry, enzymology of glycan formation and degradation, protein-glycan recognition, and the role of glycans in biological systems. This field is closely related to basic research, biomedicine, and biotechnology .

HY-E70304

Mannosyl-oligosaccharide 1,2-α-mannosidase IA MAN1A1	Endogenous Metabolite	Others
Mannosyl-oligosaccharide 1,2-α-mannosidase IA (MAN1A1) is a glycosidase that catalyzes the hydrolysis of α-1,2-linked mannose residues in Man(9)GlcNAc(2) to produce Man(9)GlcNAc(2) .

HY-174779

Human AREG mRNA	mRNA	Cancer
Human AREG mRNA encodes the human amphiregulin (AREG) protein, a member of the epidermal growth factor family. AREG interacts with the EGF/TGF-alpha receptor to promote the growth of normal epithelial cells, and inhibits the growth of certain aggressive carcinoma cell lines. It also functions in mammary gland, oocyte and bone tissue development.

Cat. No.	Product Name	Type

HY-NP005

Avidin, chiken egg white	Biochemical Assay Reagents
Avidin, chicken egg white is a glycoprotein derived from egg protein. Avidin, chicken egg white has excellent affinity with biotin and is often used in combination with biotin for immunoassays to detect the location of antigens in tissues .

HY-W441003

DSPE-PEG2000-IA	Biochemical Assay Reagents
DSPE-PEG2000-IA is a thiol reactive phospholipid polyPEG. The iodoacetyll group is reactive with thiol to produce a thioether linkage. The polymer can self-assemble in water to form lipid bilayer and can be used to encapsulate drugs in targeted delivery application, such as liposomal doxorubicin as an anti cancer drug or mRNA vaccine.

HY-W440902

DSPE-PEG3400-IA	Biochemical Assay Reagents
DSPE-PEG3400-IA is an iodoacetyll PEG lipid. The polymer can form lipid bilayer or micelles spontaneoulsy in water. The lipophilic tails can be used to encapsulate hydrophobic therapeutic agents while the hydrophilic head can be used to encapuslate hydrophilic drugs/nutrient, such as antibody, mRNA/DNA. The iodoacetyl group is reactive with thiol to produce a thioether linkage.

HY-W440903

DSPE-PEG5000-IA	Biochemical Assay Reagents
DSPE-PEG5000-IA is a cyclooctyne containing phospholipid PEG polymer. The polymer can self-assemble spontaneously in water to form micelles/lipid bilayer. It can be used to prepare nanoparticles or liposomes as drug carrier in targeted drug delivery system. The DBCO can react with azide molecule via copper free click chemistry to form a stable triazole bond.

HY-163970

Heparin disaccharide I-A sodium

Biochemical Assay Reagents

Heparin disaccharide I-A (sodium)is a class of biochemical reagents used in glycobiology research. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It involves carbohydrate chemistry, enzymology of glycan formation and degradation, protein-glycan recognition, and the role of glycans in biological systems. This field is closely related to basic research, biomedicine, and biotechnology .

Cat. No.	Product Name	Target	Research Area

HY-P10136

IA9 2 Publications Verification human TREM-2 182-190	TREM receptor	Inflammation/Immunology
IA9 (human TREM-2 182-190) is a potent, CNS-penetrant TREM-2 inhibitor. IA9 can diminish the release of proinflammatory cytokines and suppress joint inflammation and damage in a Collagen (HY-P5003)-induced arthritis (CIA) mouse model. IA9 can be used for neuroinflammation PET imaging. IA9 can be used for Rheumatoid arthritis (RA) and neuroinflammation research .

HY-P10136A

IA9 TFA 2 Publications Verification human TREM-2 182-190 TFA	TREM receptor	Inflammation/Immunology
IA9 TFA (human TREM-2 182-190 TFA) is a potent, CNS-penetrant TREM-2 inhibitor. IA9 TFA can diminish the release of proinflammatory cytokines and suppress joint inflammation and damage in a Collagen (HY-P5003)-induced arthritis (CIA) mouse model. IA9 TFA can be used for neuroinflammation PET imaging. IA9 TFA can be used for Rheumatoid arthritis (RA) and neuroinflammation research .

HY-P1047

β-Sheet Breaker Peptide iAβ5 [Pro18, Asp21] β-Amyloid (17-21)	Amyloid-β	Neurological Disease
β-Sheet Breaker Peptide iAβ5 is an effective brain amyloid-β (Abeta) degrader. Abeta deposits are associated with Alzheimer's disease (AD), and the related toxicity arises from its β-sheet conformation and aggregation. β-Sheet Breaker Peptide iAβ5 can repeatedly induce the degradation of fibrillary amyloid deposits in vivo. Therefore, β-Sheet Breaker Peptide iAβ5 can prevent and/or reverse neuronal contraction caused by Abeta and reduce the range of interleukin IL-1beta positive microglial-like cells around Abeta deposits. β-Sheet Breaker Peptide iAβ5 can reduce the size and/or number of brain amyloid plaques in AD. β-Sheet Breaker Peptide iAβ5 is labeled with a hydrophobic benzyl alcohol (HBA) tag and shows a bright blue color under acidic conditions, which can be used for quantitative determination.

HY-P10159

DJK-5	Bacterial	Infection
Diplacol ia a natural compound from from Mimulus clevelandi and shows potent inhibitory activities against lipopolysaccharide (LPS)-induced nitric oxide production .

HY-P5721

Apidaecin IA	Bacterial	Infection
Apidaecin IA is an antibacterial peptide that can be found in honeybees .

HY-P5305A

GAD65(247-266) epitope TFA	GABA Receptor	Metabolic Disease
GAD65(247-266) epitope TFA is the T cell epitopes of islet antigens，binding to I-A ^g7 (type I diabetes-associated molecule) competitively with poor affinity. GAD65 refers to Glutamic Acid Decarboxylase 65，involved in the conversion of glutamate to gamma-aminobutyric acid (GABA) .

HY-P11825

APH-IN-1	Bacterial	Infection
APH-IN-1 is an Aminoglycoside phosphotransferase (APH) inhibitor with a K_d values of 63 nM against Escherichia coli *APH(3′)-Ia*. APH-IN-1 binds primarily to the ATP-binding pocket of APH in an ATP-competitive manner, with binding affinity enhanced by divalent metal ions (Mg ²⁺ and Ca ²⁺). APH-IN-1 can be used for the research of aminoglycoside-resistant bacterial infections .

Cat. No.	Product Name	Target	Research Area	Image

HY-108738

Daclizumab Ro 24-7375	Interleukin Related Apoptosis	Inflammation/Immunology Cancer
Daclizumab (Ro 24-7375) is a humanized, monoclonal antibody that blocks CD25 (α-subunit of the high-affinity interleukin-2 receptor (IL-2R-HA)). Daclizumab inhibits effector T cell activation, regulatory T cell (Treg) expansion and survival, and activation-induced T-cell apoptosis. Daclizumab increases IL-2 bioavailability to bind to the intermediate-affinity IL-2R (IL-2R-IA), driving the expansion of anti-inflammatory CD56bright natural killer (NK) cells. Daclizumab can be used for multiple sclerosis and cancer research .

HY-P990188

*Anti-Mouse MHC class II (I-A) Antibody (Y-3P)*	MHC	Inflammation/Immunology
Anti-Mouse MHC class II (I-A) Antibody (Y-3P) is a mouse-derived IgG2a κ type antibody inhibitor, targeting to mouse MHC class II. Anti-Mouse MHC class II (I-A) Antibody (Y-3P) reacts with mouse MHC Class II haplotypes I-Ab, I-Af, I-Ap, I-Aq, I-Ar, I-As, I-Au, I-Av, and weakly with I-Ak. Anti-Mouse MHC class II (I-A) Antibody (Y-3P) blocks MHC class II and inhibits expansion of regulate T cells. Anti-Mouse MHC class II (I-A) Antibody (Y-3P) can be used for the immunology research .

HY-P991966

Anti-Human/Mouse EGFR Antibody (7A7)	EGFR	Cancer
Anti-Human/Mouse EGFR Antibody (7A7) ia an anti-mouse EGFR monoclonal antibody proposed to be the mouse equivalent of cetuximab. Anti-Human/Mouse EGFR Antibody (7A7) fails to induce tumor regression in the HPV38 tumor model where EGFR is not expressed in mice. Anti-Human/Mouse EGFR Antibody (7A7) can be used in EGFR-expressing HPV38 tumor-related studies .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0554

Escin IA 1 Publications Verification	Infection Triterpenes Structural Classification other families Classification of Application Fields Terpenoids Hippocastanaceae Aesculus hippocastanum Plants Disease Research Fields Source Classification Cancer	HIV Protease Monoamine Oxidase
Escin IA is an oral LOXL2 inhibitor and EMT inhibitor, with selectivity for LOXL2-expressing cells. Escin IA suppresses invasion, migration, and metastasis of breast cancer cells, and acts as the primary anti-TNBC metastasis constituent of Aesculus chinensis Bunge fruit saponin fraction. Escin IA can be used for the research of triple-negative breast cancer, acute inflammation, and ethanol-induced gastric mucosal lesions .

HY-A0279A

Pristinamycin IA 1 Publications Verification Mikamycin B; Mikamycin IA	Microorganisms Macrolide Antibiotics Classification of Application Fields Antibiotics Cyclopeptides Other Diseases Antibacterial Disease Research Disease Research Fields Source Classification	Bacterial Antibiotic
Pristinamycin IA (Mikamycin B) is a cycle-peptidic macrolactone antibiotic. Pristinamycin IA is a substrate of P-glycoprotein and inhibits its function. Pristinamycin IA is active against StaphyloEoccus and Srreptococcus .

HY-N1474

Picfeltarraenin IA	Picria felterrae Lour. Infection Triterpenes Classification of Application Fields Terpenoids Scrophulariaceae Plants Inflammation/Immunology Disease Research Fields Source Classification	Cholinesterase (ChE)
Picfeltarraenin IA, a triterpenoid obtained from Picriafel-terrae Lour (P.fel-terrae), is an acetylcholinesterase (AChE) inhibitor. Picfeltarraenin IA can be used for the treatment of herpes infections, cancer and inflammation .

HY-N0556

Isoescin IA	Other Terpenoids Infection Aesculus chinensis Bunge Classification of Application Fields Terpenoids Hippocastanaceae Plants Disease Research Fields Source Classification	HIV Protease
Isoescin IA is a triterpenoid saponin isolated from the seeds of Aesculus chinensis. Isoescin IA has anti-HIV-1 protease activity .

HY-N11070

23-Epi-26-deoxycimicifugoside	Triterpenes Terpenoids Ranunculaceae Plants Cimicifuga racemosa (L.) Nutt. Source Classification	Others
23-Epi-26-deoxycimicifugoside ia a triterpene xyloside that can be isolated from Cimicifuga racemosa .

HY-19829

Sandramycin	Infection Microorganisms Classification of Application Fields Antibiotics Antibacterial Disease Research Anticancer Disease Research Fields Other Antibiotics Source Classification	ADC Payload Bacterial Antibiotic
Sandramycin ia a cyclic depsipeptide antibiotic isolated from cultured broth of a Nocardioides sp. Sandramycin is also a DNA intercalator that potently binds DNA and is an ADC cytotoxin. Sandramycin is active against Gram-positive bacteria and has potent antitumor activity .

HY-N0556R

Isoescin IA (Standard)	Other Terpenoids Aesculus chinensis Bunge Structural Classification Terpenoids Hippocastanaceae Plants Source Classification	Reference Standards HIV Protease
Isoescin IA (Standard) is the analytical standard of Isoescin IA. This product is intended for research and analytical applications. Isoescin IA is a triterpenoid saponin isolated from the seeds of Aesculus chinensis. Isoescin IA has anti-HIV-1 protease activity .

HY-N0554R

Escin IA (Standard)	Triterpenes Structural Classification other families Terpenoids Hippocastanaceae Aesculus hippocastanum Plants Source Classification	Reference Standards HIV Protease
Escin IA (Standard) is the analytical standard of Escin IA. This product is intended for research and analytical applications. Escin IA is a triterpene saponin isolated from Aesculus hippocastanum, which inhibits HIV-1 protease with IC50 values of 35 μM. Escin IA has anti-TNBC metastasis activity, and its action mechanisms involved inhibition of epithelial-mesenchymal transition process by down-regulating LOXL2 expression .

HY-A0279AR

Pristinamycin IA (Standard) Mikamycin B (Standard); Mikamycin IA (Standard)	Structural Classification Microorganisms Macrolide Antibiotics Antibiotics Cyclopeptides Antibacterial Disease Research Source Classification	Reference Standards Bacterial Antibiotic
Pristinamycin IA (Standard) is the analytical standard of Pristinamycin IA. This product is intended for research and analytical applications. Pristinamycin IA (Mikamycin B) is a cycle-peptidic macrolactone antibiotic. Pristinamycin IA is a substrate of P-glycoprotein and inhibits its function. Pristinamycin IA is active against StaphyloEoccus and Srreptococcus[1].

HY-N1474R

Picfeltarraenin IA (Standard)	Picria felterrae Lour. Triterpenes Structural Classification Terpenoids Scrophulariaceae Plants Source Classification	Reference Standards Cholinesterase (ChE) Interleukin Related PGE synthase NF-κB COX
Picfeltarraenin IA (Standard) is the analytical standard of Picfeltarraenin IA (HY-N1474). This product is intended for research and analytical applications. Picfeltarraenin IA is an Acetylcholinesterase inhibitor. Picfeltarraenin IA can be extracted from the plant Picria fel-terrae Lour. Picfeltarraenin IA reduces the production of IL-8 and PGE2. Picfeltarraenin IA inhibits COX2 via the NF-κB pathway. Picfeltarraenin IA can be used in the research of respiratory system diseases .

HY-N7576

Anemarrhenasaponin Ia	Structural Classification Liliaceae Classification of Application Fields Anemarrhena asphodeloides Bunge Plants Inflammation/Immunology Disease Research Fields Steroids Source Classification	Others
Anemarrhenasaponin Ia is a steroidal saponin that can be isolated from the rhizomes of Anemarrhena asphodeloides Bunge. Anemarrhenasaponin Ia inhibits platelet aggregation. Anemarrhenasaponin Ia induces mild concentration-dependent hemolysis. Anemarrhenasaponin Ia inhibits fMLP- and AA-induced superoxide anion production, while enhancing PMA-induced superoxide anion production. Anemarrhenasaponin Ia can be used in studies related to thrombosis .

HY-N14877

Enactin Ia	Natural Products Microorganisms Source Classification	Fungal
Enactin Ia is found in the strain of Streptomyces roseoviridis. Enactin Ia has only weak antifungal activity.

HY-N15226

Butyrolactone Ia	Microorganisms Phenols Source Classification	NO Synthase Interleukin Related Autophagy
Butyrolactone Ia is the inhibitor for the NO production with an IC₅₀ of 18 μM. Butyrolactone Ia inhibits LPS (HY-D1056)-induced mRNA expression of iNOS and the inflammatory cytokine IL-1β. Butyrolactone Ia modulates autophagy in HeLa cells, and exhibits immune suppressive activity .

HY-N13692

Cinchonain Ia	Cinchona succirubra Pav. ex Klotzsch Flavonoids Rubiaceae Plants Other Flavonoids Source Classification	Others
Cinchonain Ia is a natural product .

HY-P5721

Apidaecin IA	Structural Classification Animals Ketones, Aldehydes, Acids Source Classification	Bacterial
Apidaecin IA is an antibacterial peptide that can be found in honeybees .

HY-N13082

Deacetylescin Ia	Aesculus chinensis Bunge Triterpenes Terpenoids Hippocastanaceae Plants Source Classification	Others
Deacetylescin Ia (compound 12) is a deacetylated compound with anti-hyperglycemic effects that can be extracted from the debittered Aesculus and deacetylated at the C-22 position. Deacetylescin Ia (100 mg/kg) can inhibit blood glucose elevation in mouse glucose tolerance tests .

HY-N8500

Aristolochic acid Ia	Natural Products Aristolochia debilis Sieb. et Zucc. Plants Aristolochiaceae Source Classification	Drug Metabolite
Aristolochic acid Ia is an oxidative metabolite of aristolochic acid I, which can be used to study the detoxification pathway of aristolochic acid metabolism .

HY-N12493

Eucomoside B	Eucommia ulmoides Oliver Iridoids Terpenoids Eucommiaceae Plants Source Classification	Others
Eucomoside B (compound b) ia a natural product isolated from Green Leaves of Eucommia ulmoides .

HY-B1167A

Ajmaline hydrochloride Cardiorythmine hydrochloride; (+)-Ajmaline hydrochloride	Rauvolfia verticillata (Lour.) Baill. Apocynaceae Natural Products Plants Source Classification	Others
Ajmaline hydrochloride is a Class Ia antiarrhythmic agent. It inhibits HERG potassium channels with IC50s of 1.0 μmol/l and 42.3 μmol/l in HEK cells and moth spider oocytes respectively. The inhibitory effect of Ajmaline hydrochloride is rapid, reversible, and positive frequency dependent. It acts primarily on the open state of the HERG channel and may also be combined with the inactivated state. The inhibitory effect of ajmaline hydrochloride is dependent on aromatic residues in the S6 domain, and the sensitivity is significantly reduced in the inactivation-deficient HERG S620T channel. It can also slightly affect the activation voltage of HERG channels. Ajmaline hydrochloride's inhibitory effect on HERG channels may contribute to both its potent antiarrhythmic effects and its potential proarrhythmic risk.

HY-N19874

Mukurozioside Ia	Structural Classification Terpenoids Sesquiterpenes Sapindaceae Sapindus rarak DC. Plants Source Classification
Mukurozioside Ia is an acyclic sesquiterpene oligoglycoside found in the pericarps of Sapindus rarak. Mukurozioside Ia can be used in the study of metabolic diseases .

HY-N13766

Euglobal Ia2	Other Terpenoids Structural Classification Eucalyptus loxophleba Benth. Terpenoids Myrtaceae Plants Source Classification	Drug Derivative
Euglobal Ia2 is a natural terpenoid.

HY-N9718

Euglobal Ia1	Triterpenes Structural Classification Terpenoids Myrtaceae Plants Eucalyptus globulus Labill. Source Classification	Drug Derivative
Euglobal Ia1 is a natural terpenoid.

Species:	Human (13) Mouse (5) E.coli (1) Canine (1)
Tag:	His (14) Tag Free (3) Myc (1) Fc (5)
Source:	HEK293 (9) P. pastoris (1) E. coli (10)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P78262

	CD74 Protein, Mouse (224a.a, HEK293, His) CD74; Ii; DHLAG; HLADG; IA-GAMMA; p33; CLIP; INVG34; IA-GAMMA ; II	Mouse	HEK293
	The CD74 protein is significantly expressed in the thymus and lymph nodes, suggesting that it plays a key role in regulating immune system function. Its presence in the thymus, a key site for T cell development, underscores its important role in overseeing key cellular processes required for immune maturation. CD74 Protein, Mouse (224a.a, HEK293, His) is the recombinant mouse-derived CD74 protein, expressed by HEK293 , with N-His labeled tag.

HY-P7070

	IGF-I/IGF-1 Protein, Mouse 10+ Cited Publications rMuIGF-1; IGF-IA; Somatamedin C; MGF; IGF-I	Mouse	E. coli
	IGF-I/IGF-1 Protein is an insulin-like growth factor that possesses both growth-promoting and metabolic-regulating functions. IGF-I/IGF-1 Protein is also a neurotrophic factor with neuroprotective and neuroplasticity-regulating activities. IGF-I/IGF-1 Protein plays a key role in growth and development, cell proliferation, metabolic regulation and other aspects. IGF-I/IGF-1 Protein, Mouse is a recombinant IGF-I/IGF-1 protein expressed by E. coli without a tag.

HY-P70848

	IA2 Protein, Human (His) Receptor-type tyrosine-protein phosphatase-like N; R-PTP-N; Islet cell antigen 512; ICA 512; Islet cell autoantigen 3; PTP IA-2; PTPRN; ICA3; ICA512	Human	E. coli
	The IA2 protein is critical in the vesicle-mediated secretion process and is essential for the accumulation of secretory vesicles in the hippocampus, pituitary gland, and pancreatic islets. IA2 is critical for insulin-related functions, ensuring normal levels of insulin-containing vesicles, preventing degradation and promoting glucose-stimulated insulin secretion. IA2 Protein, Human (His) is the recombinant human-derived IA2 protein, expressed by E. coli , with N-6*His labeled tag.

HY-P7018

	IGF-I/IGF-1 Protein, Human (70a.a) Maximum Cited Publications 24 Publications Verification rHuIGF-1; IGF-IA; Somatamedin C; MGF; IGF-I	Human	E. coli
	IGF-I/IGF-1 Protein is an insulin-like growth factor that possesses both growth-promoting and metabolic-regulating functions. IGF-I/IGF-1 Protein is also a neurotrophic factor with neuroprotective and neuroplasticity-regulating activities. IGF-I/IGF-1 Protein plays a key role in growth and development, cell proliferation, metabolic regulation and other aspects. IGF-I/IGF-1 protein, Human (70a.a) is a recombinant IGF-I/IGF-1 protein expressed by E. coli without a tag.

HY-P72279

	Outer membrane porin F/OmpF Protein, E.coli (His, Myc) Outer membrane protein B; Outer membrane protein IA	E.coli	E. coli
	Outer membrane protein F (OmpF) facilitates the formation of pores, enabling the passive diffusion of small molecules across the bacterial outer membrane. Beyond its role in membrane permeability, OmpF serves as a crucial receptor for the bacteriophage T2 and is considered the primary receptor for colicin E5, playing a probable role in the mechanisms associated with these interactions. Outer membrane porin F/OmpF Protein, E.coli (His, Myc) is the recombinant E. coli-derived Outer membrane protein F/OmpF protein, expressed by E. coli , with C-Myc, N-10*His labeled tag.

HY-P70698AF

	Animal-Free IGF-I/IGF-1 Protein, Mouse (His) rMuIGF-1; IGF-IA; Somatamedin C; MGF; IGF-I	Mouse	E. coli
	The IGF-I/IGF-1 protein is structurally similar to insulin and has potent growth-promoting activity. As a physiological regulator, it stimulates glucose transport and glycogen synthesis in osteoblasts, exceeding the efficacy of insulin at lower concentrations. Animal-Free IGF-I/IGF-1 Protein, Mouse (His) is the recombinant mouse-derived animal-FreeIGF-I/IGF-1 protein, expressed by E. coli , with C-His labeled tag.This product is for cell culture use only.

HY-P7018A

	DES1-3 IGF-I/IGF-1 Protein, Human rHuIGF-1; IGF-IA; Somatamedin C; MGF; IGF-I	Human	E. coli

HY-P704375

	IGF-I/IGF-1 Protein, Mouse (HEK293, hFc) rMuIGF-1; IGF-IA; Somatamedin C; MGF; IGF-I	Mouse	HEK293
	The IGF-I/IGF-1 protein is structurally similar to insulin and has potent growth-promoting activity. As a physiological regulator, it stimulates glucose transport and glycogen synthesis in osteoblasts, exceeding the efficacy of insulin at lower concentrations. IGF-I/IGF-1 Protein, Mouse (HEK293, hFc) is the recombinant mouse-derived IGF-I/IGF-1 protein, expressed by HEK293, with N-hFc labeled tag.

HY-P70847A

	IA2 Protein, Human (293a.a, N-His) Receptor-type tyrosine-protein phosphatase-like N; R-PTP-N; Islet cell antigen 512; ICA 512; Islet cell autoantigen 3; PTP IA-2; PTPRN; ICA3; ICA512	Human	E. coli
	The IA2 protein is critical in the vesicle-mediated secretion process and is essential for the accumulation of secretory vesicles in the hippocampus, pituitary gland, and pancreatic islets. IA2 is critical for insulin-related functions, ensuring normal levels of insulin-containing vesicles, preventing degradation and promoting glucose-stimulated insulin secretion. IA2 Protein, Human (293a.a, N-His) is the recombinant human-derived IA2 protein, expressed by E. coli , with N-6*His labeled tag.

HY-P70847

	IA2 Protein, Human (293a.a, His, solution) Receptor-type tyrosine-protein phosphatase-like N; R-PTP-N; Islet cell antigen 512; ICA 512; Islet cell autoantigen 3; PTP IA-2; PTPRN; ICA3; ICA512	Human	E. coli
	The IA2 protein is critical in the vesicle-mediated secretion process and is essential for the accumulation of secretory vesicles in the hippocampus, pituitary gland, and pancreatic islets. IA2 is critical for insulin-related functions, ensuring normal levels of insulin-containing vesicles, preventing degradation and promoting glucose-stimulated insulin secretion. IA2 Protein, Human (293a.a, His, solution) is the recombinant human-derived IA2 protein, expressed by E. coli , with N-6*His labeled tag.

HY-P75594

	BMPR1A/ALK-3 Protein, Human (HEK293, His) ALK-3; BMPRIA; Bone morphogenetic protein receptor type-1A; SKR5; CD292	Human	HEK293
	BMPR1A/ALK-3 protein (ACVRLK3) is the receptor bone morphogenetic protein (BMP) type I receptors, widely expressed in tissues. BMPR1A/ALK-3 protein mediates iron metabolism factor hepcidin expression, interacts with GDF5/6 to regulate chondrocyte differentiation and adipogenesis. BMPR1A-ID2/ZEB1-TGFBR2 signaling axis could serve as a potentia target for pulmonary arterial hypertension (PAH) and other endothelial-mesenchymal transition (EndoMT)-related vascular disorders. Human BMPR1A/ALK-3 has a full length of 532 a.a., with a motif (107-109 a.a.) mediating specificity for BMP ligand. BMPR1A/ALK-3 Protein, Human (HEK293, His) is produced in HEK293 cells, with a C-terminal His-tags.

HY-P703876

	BMPR1A/ALK-3 Protein, Human (HEK293, hFc) ALK-3; BMPRIA; Bone morphogenetic protein receptor type-1A; SKR5; CD292	Human	HEK293
	BMPR1A/ALK-3 Protein, Human (HEK293, hFc) is the recombinant human-derived BMPR1A/ALK-3 protein, expressed by HEK293, with C-hFc tag.

HY-P76173

	BMPR1A/ALK-3 Protein, Canine (HEK293, Fc) Bone morphogenetic protein receptor type-1A; ALK-3; SKR5; CD292; ACVRLK3; BMPR-IA	Canine	HEK293
	BMPR1A/ALK-3 protein (ACVRLK3) is the receptor bone morphogenetic protein (BMP) type I receptors, widely expressed in tissues. BMPR1A/ALK-3 protein mediates iron metabolism factor hepcidin expression, interacts with GDF5/6 to regulate chondrocyte differentiation and adipogenesis. BMPR1A-ID2/ZEB1-TGFBR2 signaling axis could serve as a potentia target for pulmonary arterial hypertension (PAH) and other endothelial-mesenchymal transition (EndoMT)-related vascular disorders. BMPR1A/ALK-3 Protein, Canine (HEK293, Fc) is a recombinant protein produced in the HEK293 cells with C-terminal hFc-tag.

HY-P7483

	BMPR1A/ALK-3 Protein, Mouse (HEK293, His-Fc) Bone morphogenetic protein receptor type-1A; ALK-3; SKR5; CD292; ACVRLK3; BMPR-IA	Mouse	HEK293
	BMPR1A/ALK-3 protein (ACVRLK3) is the receptor bone morphogenetic protein (BMP) type I receptors, widely expressed in tissues. BMPR1A/ALK-3 protein mediates iron metabolism factor hepcidin expression, interacts with GDF5/6 to regulate chondrocyte differentiation and adipogenesis. BMPR1A-ID2/ZEB1-TGFBR2 signaling axis could serve as a potentia target for pulmonary arterial hypertension (PAH) and other endothelial-mesenchymal transition (EndoMT)-related vascular disorders. Mouse BMPR1A/ALK-3 has a full length of 532 a.a., with a motif (107-109 a.a.) mediating specificity for BMP ligand. BMPR1A/ALK-3 Protein, Mouse (HEK293, His-Fc) is produced in HEK293 cells and has 129 amino acids (Q24-R152), with C-terminal Fc and His-tags.

HY-P7484

	BMPR1A/ALK-3 Protein, Human (HEK293, Fc-His) Bone morphogenetic protein receptor type-1A; ALK-3; SKR5; CD292; ACVRLK3; BMPR-IA	Human	HEK293
	BMPR1A/ALK-3 protein (ACVRLK3) is the receptor bone morphogenetic protein (BMP) type I receptors, widely expressed in tissues. BMPR1A/ALK-3 protein mediates iron metabolism factor hepcidin expression, interacts with GDF5/6 to regulate chondrocyte differentiation and adipogenesis. BMPR1A-ID2/ZEB1-TGFBR2 signaling axis could serve as a potentia target for pulmonary arterial hypertension (PAH) and other endothelial-mesenchymal transition (EndoMT)-related vascular disorders. Human BMPR1A/ALK-3 has a full length of 532 a.a., with a motif (107-109 a.a.) mediating specificity for BMP ligand. BMPR1A/ALK-3 Protein, Human (HEK293, Fc-His) is produced in HEK293 cells and has 129 amino acids (Q24-R152), with C-terminal Fc and His-tags.

HY-P71227

	PPM1A Protein, Human (His) Protein Phosphatase 1A; Protein Phosphatase 2C Isoform Alpha; PP2C-Alpha; Protein Phosphatase IA; PPM1A; PPPM1A	Human	E. coli
	PPM1A is a multifunctional enzyme that negatively regulates multiple signaling pathways. It significantly attenuates TGF-β signaling by dephosphorylating SMAD2 and SMAD3, leading to their dissociation from SMAD4, nuclear export, and signal termination. PPM1A Protein, Human (His) is the recombinant human-derived PPM1A protein, expressed by E. coli , with C-6*His labeled tag.

HY-P700093AF

	Animal-Free IGF-I/IGF-1 Protein, Human (His) 1 Publications Verification Somatamedin C; IGF-IA; Insulin-Like Growth Factor I; IGF-I; Mechano Growth Factor; MGF; Somatomedin-C; IGF1; IBP1	Human	E. coli
	The LR3 IGF-I/IGF-1 protein is similar to insulin and has potent growth-promoting activity that exceeds the efficacy of insulin. As a potential physiological regulator, it stimulates glucose transport and glycogen synthesis in osteoblasts even at significantly lower concentrations than insulin. Animal-Free IGF-I/IGF-1 Protein, Human (His) is the recombinant human-derived animal-FreeIGF-I/IGF-1 protein, expressed by E. coli , with C-His labeled tag.This product is for cell culture use only.

HY-P704374

	IGF-I/IGF-1 Protein, Human (HEK293, N-His) 1 Publications Verification Somatamedin C; IGF-IA; Insulin-Like Growth Factor I; IGF-I; Mechano Growth Factor; MGF; Somatomedin-C; IGF1; IBP1	Human	HEK293
	The LR3 IGF-I/IGF-1 protein is similar to insulin and has potent growth-promoting activity that exceeds the efficacy of insulin. As a potential physiological regulator, it stimulates glucose transport and glycogen synthesis in osteoblasts even at significantly lower concentrations than insulin. IGF-I/IGF-1 Protein, Human (HEK293, N-His) is the recombinant human-derived IGF-I/IGF-1 protein, expressed by HEK293, with N-His labeled tag.

HY-P71792

	TYR Protein, Human (P.pastoris, His) 2 Publications Verification ATN; CMM8; LB24 AB; LB24-AB; OCA1; OCA1A; OCAIA; Oculocutaneous albinism IA; SHEP3; SK29 AB; SK29-AB; Tumor rejection antigen AB; TYR; Tyrosinase	Human	P. pastoris
	TYR protein, a copper-containing oxidase, initiates melanin production by catalyzing the hydroxylation of tyrosine to DOPA. This essential step is rate-limiting in the synthesis of melanins and polyphenolic compounds. TYR further enables the oxidation of DOPA to DOPA-quinone and potentially mediates the conversion of DHI to indole-5,6 quinone, playing a crucial role in the intricate cascade of reactions involved in melanin biosynthesis. TYR Protein, Human (P.pastoris, His) is the recombinant human-derived TYR protein, expressed by P. pastoris , with N-His, N-6*His labeled tag.

HY-P79018

	TYR Protein, Human (HEK293, His) ATN; CMM8; LB24 AB; LB24-AB; OCA1; OCA1A; OCAIA; Oculocutaneous albinism IA; SHEP3; SK29 AB; SK29-AB; Tumor rejection antigen AB; TYR; Tyrosinase	Human	HEK293
	TYR protein, a copper-containing oxidase, initiates melanin production by catalyzing the hydroxylation of tyrosine to DOPA. This essential step is rate-limiting in the synthesis of melanins and polyphenolic compounds. TYR further enables the oxidation of DOPA to DOPA-quinone and potentially mediates the conversion of DHI to indole-5,6 quinone, playing a crucial role in the intricate cascade of reactions involved in melanin biosynthesis. TYR Protein, Human (HEK293, His) is the recombinant human-derived TYR protein, expressed by HEK293 , with N-6*His labeled tag.

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Cat. No.	Product Name	Chemical Structure

HY-B0971S

Pheniramine-d6 maleate
Pheniramine-d₆ (maleate) is the deuterium labeled Pheniramine maleate. Pheniramine Maleate ia an antihistamine and vasoconstrictor.

HY-106577S

Cibenzoline-d4

Cibenzoline-d₄ (Cifenline-d₄) is deuterium labeled Cibenzoline. Cibenzoline is a class Ia antiarrhythmic active molecule with low anticholinergic activity. Cibenzoline is a K_ATP channel inhibitor, acting through the pore forming subunit Kir6.2, with an IC₅₀ of 22.2 μM. Cibenzoline inhibits I_Kr and I_Ks currents with IC₅₀ values of 8.8 μM and 12.3 μM, respectively. Cibenzoline is used in the study of cardiac diseases. In addition, Cibenzoline can induce hypoglycemia .

HY-106577S1

Cibenzoline-d5

Cibenzoline-d₅ (Cifenline-d₅) is deuterium labeled Cibenzoline. Cibenzoline is a class Ia antiarrhythmic active molecule with low anticholinergic activity. Cibenzoline is a K_ATP channel inhibitor, acting through the pore forming subunit Kir6.2, with an IC₅₀ of 22.2 μM. Cibenzoline inhibits I_Kr and I_Ks currents with IC₅₀ values of 8.8 μM and 12.3 μM, respectively. Cibenzoline is used in the study of cardiac diseases. In addition, Cibenzoline can induce hypoglycemia .

Host:	Mouse (14) Rabbit (9)
Reactivity:	Human (22) Rat (2) Mouse (7) Dog (1) human (1)
Application:	IHC-P (14) ICC/IF (7) IF-Tissue (1) IP (4) IHC-F (2) WB (14) FC (11) ELISA (15)
Isotype:	IgA (1) IgG2a,IgG/Kappa (1) IgG (9) IgG1 (6) IgG2a (4)
Conjugation:	Non-conjugated (23)
Clonality:	Polyclonal (1) Monoclonal (13) Monoclonal Antibody (1) Recombinant (4)
Modification:	Unmodified (16)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P89605

	PTP IA-2 Antibody (YA8949)	WB, IP, ELISA	human
	PTP IA-2 Antibody (YA8949) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to PTP IA-2.

HY-P83941

	CD74 Antibody (YA3638) II; DHLAG; HLADG; IA-GAMMA	WB, ICC/IF, FC, ELISA	Human
	CD74 Antibody (YA3638) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CD74.

HY-P83941A

	CD74 Antibody (YA3638)(PBS only) II; DHLAG; HLADG; IA-GAMMA	WB, ICC/IF, FC, ELISA	Human
	CD74 Antibody (YA3638) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CD74.

HY-P84085

	Integrin alpha 4/CD49D Antibody (YA3782) ITGA4; IA4	WB, FC, ELISA	Human
	Integrin alpha 4/CD49D Antibody (YA3782) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to Integrin alpha 4/CD49D.

HY-P84085A

	Integrin alpha 4/CD49D Antibody (YA3782)(PBS only) ITGA4; IA4	WB, FC, ELISA	Human
	Integrin alpha 4/CD49D Antibody (YA3782) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to Integrin alpha 4/CD49D.

HY-P86053

	Tyrosinase Antibody (YA5745) ATN; CMM8; LB24 AB; LB24-AB; Monophenol monooxygenase; OCA1; OCA1A; OCAIA; Oculocutaneous albinism IA; SHEP3; SK29 AB; SK29-AB; Tumor rejection antigen AB; TYR; TYRO_HUMAN; tyrosinase; oculocutaneous albinism IA; Tyrosinase	IHC-P, ICC/IF, ELISA	Human
	Tyrosinase Antibody (YA5745) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Tyrosinase.

HY-P85966

	Tyrosinase Antibody (YA5658) ATN; CMM8; LB24 AB; LB24-AB; Monophenol monooxygenase; OCA1; OCA1A; OCAIA; Oculocutaneous albinism IA; SHEP3; SK29 AB; SK29-AB; Tumor rejection antigen AB; TYR; TYRO_HUMAN; tyrosinase; oculocutaneous albinism IA; Tyrosinase	IHC-P, WB, ICC/IF, ELISA	Human, Mouse
	Tyrosinase Antibody (YA5658) is a Mouse-derived and non-conjugated IgA monoclonal antibody, targeting to Tyrosinase.

HY-P82249

	Activin Receptor Type IA Antibody (YA1994) ACTRI; Acvr1; ACVR1A; ACVRLK2; ALK2; FOP; SKR1; TSRI	WB, IP	Human, Mouse
	Activin Receptor Type IA Antibody (YA1994) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Activin Receptor Type IA.

HY-P82249A

	Activin Receptor Type IA Antibody (YA1994)(PBS only) ACTRI; Acvr1; ACVR1A; ACVRLK2; ALK2; FOP; SKR1; TSRI	WB, IP	Human, Mouse
	Activin Receptor Type IA Antibody (YA1994) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Activin Receptor Type IA.

HY-P84227

	CD82 Antibody (YA3924) R2; 4F9; C33; IA4; ST6; GR15; KAI1; SAR2; TSPAN27	IHC-P, FC, ELISA	Human, Mouse
	CD82 Antibody (YA3924) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to CD82.

HY-P84228

	CD82 Antibody (YA3925) R2; 4F9; C33; IA4; ST6; GR15; KAI1; SAR2; TSPAN27	WB, IHC-P, FC, ELISA	Human
	CD82 Antibody (YA3925) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CD82.

HY-P84227A

	CD82 Antibody (YA3924)(PBS only) R2; 4F9; C33; IA4; ST6; GR15; KAI1; SAR2; TSPAN27	IHC-P, FC, ELISA	Human, Mouse
	CD82 Antibody (YA3924) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to CD82.

HY-P84228A

	CD82 Antibody (YA3925)(PBS only) R2; 4F9; C33; IA4; ST6; GR15; KAI1; SAR2; TSPAN27	WB, IHC-P, FC, ELISA	Human
	CD82 Antibody (YA3925) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CD82.

HY-P81388

	CD82 Antibody (YA1133) C33; CD82; IA4; Inducible membrane protein; KAI1; Kangai1; SAR2; ST6; Tetraspanin 27; Tspan27	IHC-P	Human
	CD82 Antibody (YA1133) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CD82.

HY-P81388A

	CD82 Antibody (YA1133)(PBS only) C33; CD82; IA4; Inducible membrane protein; KAI1; Kangai1; SAR2; ST6; Tetraspanin 27; Tspan27	IHC-P	Human
	CD82 Antibody (YA1133) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CD82.

HY-P81537

	CD74 Antibody (YA1282) CD74; DHLAG; HLA class II histocompatibility antigen gamma chain; HLA-DR antigens-assocIAted invarIAnt chain; IA antigen-assocIAted invarIAnt chain; Ii; p33; CD74	IHC-P	Human
	CD74 Antibody (YA1282) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CD74.

HY-P81112

	IGF1 Antibody IBP1; IGF 1; IGF I; IGF-1; IGF IA; IGF IB; IGF1; IGFI; IGFIA; Insulin like growth factor 1 (somatomedin C); Full=Insulin-like growth factor I; Insulin Like Growth Factor 1; Insulin like growth factor IA; Insulin like growth factor IB; Mechano growth factor; MGF; Mechano growth factor; MGF; SomatomedIA C; Somatomedin C; IGF1_HUMAN. IGF-I;	WB, IHC-P, IHC-F, ICC/IF, ELISA	Human, Mouse, Rat, Dog
	IGF1 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to IGF1.

HY-P85007

	CD74 Antibody (YA4699) HLA class II histocompatibility antigen gamma chain; HLA-DR antigens-assocIAted invarIAnt chain; IA antigen-assocIAted invarIAnt chain; Ii; p33; CD antigen CD74; CD74 nanobody;	ELISA, FC	Human
	CD74 Antibody (YA4699) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to CD74.

HY-P81537A

	CD74 Antibody (YA1282)(PBS only) CD74; DHLAG; HLA class II histocompatibility antigen gamma chain; HLA-DR antigens-assocIAted invarIAnt chain; IA antigen-assocIAted invarIAnt chain; Ii; p33; CD74	IHC-P	Human
	CD74 Antibody (YA1282) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CD74.

HY-P85898

	CD74 Antibody (YA5590) CD 74 antibody; CD74 antibody; CD74 antigen; invarIAnt polypeptide of major histocompatibility complex; class II antigen-assocIAted; antibody; CD74 antigen antibody; CD74 molecule antibody; CD74 molecule; major histocompatibility complex; class II invarIAnt chain antibody; CLIP antibody; DHLAG antibody; Gamma chain of class II antigens antibody; HG2A_HUMAN antibody; HLA class II histocompatibility antigen gamma chain antibody; HLA DR antigens assocIAted invarIAnt chain antibody; HLA DR gamma antibody; HLA-DR antigens-assocIAted invarIAnt chain antibody; HLA-DR-gamma antibody; HLADG antibody; HLADR antigens assocIAted invarIAnt chain antibody; IA antigen assocIAted invarIAnt chain antibody; IA antigen-assocIAted invarIAnt chain antibody; IA assocIAted invarIAnt chain antibody; IA gamma antibody; Ii antibody; InvarIAnt polypeptide of major histocompatibility complex class II antigen assocIAted antibody; la-gamma antibody; Major histocompatibility complex class II invarIAnt chain antibody; MHC HLA DR gamma chain antibody; MHC HLA-DR gamma chain antibody; p33 antibody; p35 antibody; Protein 41 antibody;	IHC-P, WB, ICC/IF, ELISA	Human
	CD74 Antibody (YA5590) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to CD74.

HY-P83362

	Integrin alpha 2 Antibody (YA3107) ITGA2; CD49B; Integrin alpha-2; CD49 antigen-like family member B; Collagen receptor; Platelet membrane glycoprotein IA; GPIA; VLA-2 subunit alpha; CD49b	WB, IHC-P, ICC/IF, IP, FC	Human, Mouse, Rat
	Integrin alpha 2 Antibody (YA3107) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Integrin alpha 2.

HY-P85009

	CD82 Antibody (YA4701) 4F9 antibody; Antigen detected by monoclonal and antibody IA4 antibody; C33 antibody; C33 antigen antibody; CD 82 antibody; CD82 antibody; CD82 antigen antibody; CD82 molecule antibody; CD82_HUMAN antibody; GR 15 antibody; GR15 antibody; IA 4 antibody; IA4 antibody; Inducible membrane protein antibody; Inducible membrane protein R2 antibody; KAI 1 antibody; KAI1 antibody; Kangai 1; suppression of tumorigenicity 6; prostate; CD82 antigen; R2 leukocyte antigen; antigen detected by monoclonal and antibody IA4; antibody; Kangai 1 antibody; Kangai1 antibody; Leukocyte surface antigen R2 antibody; Metastasis suppressor Kangai 1 antibody; Metastasis suppressor Kangai-1 antibody; Metastasis suppressor Kangai1 antibody; Prostate cancer antimetastasis gene KAI1 antibody; R2 antibody; R2 leukocyte antigen antibody; SAR 2 antibody; SAR2 antibody; ST 6 antibody; ST6 antibody; Suppression of tumorigenicity 6 antibody; Suppression of tumorigenicity 6 prostate antibody; Suppressor of tumorigenicity 6 antibody; Suppressor of tumorigenicity 6 protein antibody; Tetraspanin 27 antibody; Tetraspanin-27 antibody; Tetraspanin27 antibody; Tspan 27 antibody; Tspan-27 antibody; Tspan27 antibody; CD82 nanobody;	ELISA, FC	Human
	CD82 Antibody (YA4701) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to CD82.

HY-P86669

	IL-4 Antibody (YA6361) Interleukin-4; IL4; IL 4; B cell growth factor 1; B cell IgG differentIAtion factor; B Cell Stimulatory Factor 1; BCGF 1; BCGF1; Binetrakin; BSF 1; BSF1; HCGF; Hodgkin’s Cell Growth Factor; IA Inducing Factor; IGG1 induction factor; Il4e12; Interleukin 4; Interleukin 4, isoform 1; Interleukin4; Lymphocyte stimulatory factor 1; Macrophage fusion factor; Mast cell growth factor 2; MCGF2; MFF; MGC79402; Pitrakinra; T cell growth factor 2; TCGF2; IL4_HUMAN; B-cell stimulatory factor 1; BSF-1.	WB, IHC-P, IHC-F, IF-Tissue	Human
	IL-4 Antibody (YA6361) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to IL-4.

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Cat. No.	Product Name		Classification

HY-136205

IA-Alkyne 4 Publications Verification Iodoacetamide-alkyne; N-Hex-5-ynyl-2-iodo-acetamide		Alkynes
IA-Alkyne (Iodoacetamide-alkyne; N-Hex-5-ynyl-2-iodo-acetamide) is a TRP channel (TRPC) agonist and has the potential for the study of respiratory infection . IA-Alkyne can be used to develop an isotopically tagged probe for quantitative cysteine-reactivity profiling . IA-Alkyne is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Cat. No.	Product Name		Classification

HY-W440903

DSPE-PEG5000-IA		Pegylated Lipids
DSPE-PEG5000-IA is a cyclooctyne containing phospholipid PEG polymer. The polymer can self-assemble spontaneously in water to form micelles/lipid bilayer. It can be used to prepare nanoparticles or liposomes as drug carrier in targeted drug delivery system. The DBCO can react with azide molecule via copper free click chemistry to form a stable triazole bond.

HY-174779

Human AREG mRNA		mRNA
Human AREG mRNA encodes the human amphiregulin (AREG) protein, a member of the epidermal growth factor family. AREG interacts with the EGF/TGF-alpha receptor to promote the growth of normal epithelial cells, and inhibits the growth of certain aggressive carcinoma cell lines. It also functions in mammary gland, oocyte and bone tissue development.

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