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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
3 Results for "
IAPP aggregation
" in MedChemExpress (MCE) Product Catalog:
Products (3)
3 Results for "IAPP aggregation" in MCE Product Catalog:
Cat. No.: HY-P2392
CAS No.: 252554-79-3
Target:
Research Areas:
Cat. No.: HY-182304
CAS No.: 1338489-62-5
Research Areas:
CLR01 sodium is a blood-brain barrier-permeable anti-aggregation agent. CLR01 sodium inhibits the de novo aggregation of Amyloid-β 40/42, α-synuclein, IAPP, tau protein and SOD1. CLR01 sodium reduces amyloid plaque burden in the cortex of triple-transgenic mice and improves the memory and motor abilities of these mice. CLR01 sodium can be used in research related to Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS) .
Cat. No.: HY-P11899
Synonyms: Cyclo(VVIaWG)
Research Areas:
Cyclo (Val-Val-Ile-d-Ala-Trp-Gly) (Cyclo(VVIaWG)) is a six-membered cyclic peptide designed based on the C-terminal region of Aβ1-42. Cyclo (Val-Val-Ile-d-Ala-Trp-Gly) binds selectively to Aβ15-36 (Kd = 0.6 μM), regulates the aggregation of Aβ1-42 at high concentrations, weakly inhibits fibrillation at a 10-fold excess, and inhibits oligomerization at equimolar concentrations. Cyclo (Val-Val-Ile-d-Ala-Trp-Gly) does not interfere with the aggregation of IAPP. Cyclo (Val-Val-Ile-d-Ala-Trp-Gly) can serve as a targeting ligand for fluorescent probes of Aβ prefibrillar aggregates, and is applicable to research related to Alzheimer's disease .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
