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ICAD

" in MedChemExpress (MCE) Product Catalog:

By Targets:	NF-κB (1) Small Interfering RNA (siRNA) (2) Syk (1) TGF-beta/Smad (1)
By Research Areas:	Cardiovascular Disease (1) Metabolic Disease (1) Neurological Disease (1)
Oligonucleotides:	Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (2)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N7675

Flavanomarein	NF-κB TGF-beta/Smad Syk	Cardiovascular Disease Neurological Disease Metabolic Disease
Flavanomarein is a substance with cytoprotective, anti-inflammatory and antioxidant activities, with a K_a of 3.064e-5 M against human Syk. Flavanomarein enhances the phosphorylation level of AKT, regulates the expression of PKC-δ, P85α, PKC-β1, Sirt1, Bcl-2 and ICAD, and inhibits the nuclear translocation of NF-κB p65. Flavanomarein regulates EMT marker proteins, promotes the proliferation of HK-2 cells, and protects neuronal cells from 6-OHDA-induced neurotoxic damage. Flavanomarein can be used in studies related to Parkinson's disease and diabetic nephropathy.

HY-RS03708

DFFA Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
DFFA Human Pre-designed siRNA Set A contains three designed siRNAs for DFFA gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

DFFA Human Pre-designed siRNA Set A DFFA Human Pre-designed siRNA Set A

HY-RS18032

Dffa Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Dffa Mouse Pre-designed siRNA Set A contains three designed siRNAs for Dffa gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Dffa Mouse Pre-designed siRNA Set A Dffa Mouse Pre-designed siRNA Set A

Flavanomarein	Cardiovascular Disease Structural Classification Classification of Application Fields Cercis chinensis Bunge Metabolic Disease Plants Compositae Flavonoids other families Flavonones Phenols Polyphenols Disease Research Fields Source Classification	NF-κB TGF-beta/Smad Syk
Flavanomarein is a substance with cytoprotective, anti-inflammatory and antioxidant activities, with a K_a of 3.064e-5 M against human Syk. Flavanomarein enhances the phosphorylation level of AKT, regulates the expression of PKC-δ, P85α, PKC-β1, Sirt1, Bcl-2 and ICAD, and inhibits the nuclear translocation of NF-κB p65. Flavanomarein regulates EMT marker proteins, promotes the proliferation of HK-2 cells, and protects neuronal cells from 6-OHDA-induced neurotoxic damage. Flavanomarein can be used in studies related to Parkinson's disease and diabetic nephropathy.

Species:	Human (2)
Tag:	His (1) GST (1)
Source:	E. coli (2)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P7814

	*DFF45/ICAD* Protein, Human (His)** rHuDNA fragmentation factor subunit alpha/ DFF45, His; DNA Fragmentation Factor Subunit Alpha; DNA Fragmentation Factor 45 kDa Subunit; DFF-45; Inhibitor of CAD; ICAD; DFFA; DFF1; DFF45; H13	Human	E. coli
	DFF45/ICAD Protein, Human (His) is the recombinant human-derived DFF45/ICAD protein, expressed by E. coli, with N-6*His labeled tag.

HY-P700499

	DFFA Protein, Human (GST) DNA fragmentation factor, 45kDa, alpha polypeptide; DNA fragmentation factor, 45 kD, alpha polypeptide; DNA fragmentation factor subunit alpha; DFF 45; DFF1; DFF45; DNA fragmentation factor; 45 kD; alpha subunit; ICAD;	Human	E. coli
	DFFA Protein is a heterodimeric complex of nuclease CAD and its specific inhibitor ICAD. DFFA Protein, Human (GST) is a substrate for caspase-3 that triggers DNA breakage during apoptosis. DFFA Protein, Human (GST) is the recombinant human-derived DFFA protein, expressed by E. coli , with N-GST labeled tag.

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HY-P82517

	ICAD Antibody (YA2262) DFFA; DFF1; DFF45; H13; DNA fragmentation factor subunit alpha; DNA fragmentation factor 45 kDa subunit; DFF-45; Inhibitor of CAD; ICAD	WB, IHC-P, ICC/IF, IP, FC	Human
	ICAD Antibody (YA2262) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ICAD.

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Cat. No.	Product Name		Classification

HY-RS03708

DFFA Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
DFFA Human Pre-designed siRNA Set A contains three designed siRNAs for DFFA gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS18032

Dffa Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Dffa Mouse Pre-designed siRNA Set A contains three designed siRNAs for Dffa gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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