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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
17 Results for "
ILT4
" in MedChemExpress (MCE) Product Catalog:
Products (17)
17 Results for "ILT4" in MCE Product Catalog:
Cat. No.: HY-P991230
MK-4830 is a fully humanized monoclonal antibody of the immunoglobulin G4 subclass that specifically binds to ILT4 and blocks its interaction with HLA-G and other ligands. MK-4830 inhibits tumor growth in humanized mouse cancer models .
Cat. No.: HY-P991306
Target:
Research Areas:
Cat. No.: HY-P991093
Target:
Research Areas:
Cat. No.: HY-P990061
CAS No.: 2640981-19-5
Synonyms: JTX-8064
Target:
Research Areas:
Polzastobart (JTX-8064) is a humanized IgG4 monoclonal antibody and LILRB2 (ILT4) antagonist. Polzastobart specifically binds to and antagonizes LILRB2, relieves ILT4-mediated myeloid immunosuppression, and promotes the polarization of macrophages from an M2-like phenotype to an M1-like phenotype. Polzastobart induces macrophage polarization, IFNγ signaling, and T cell inflammation-related pharmacodynamic responses in ex vivo human renal cancer, lung cancer, and head and neck cancer tissues. Polzastobart can be used in studies related to tumor-associated macrophages and tumor immunity. For the isotype control of Polzastobart, refer to: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003) .
Cat. No.: HY-P77739
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: LILRB2; Monocyte/Macrophage Immunoglobulin-Like Receptor 10; Leukocyte Immunoglobulin Like Receptor B2; CD85 Antigen-Like Family Member D; MIR-10; Myeloid Inhibitory Receptor 10; LIR-2; Leucocyte Ig-Like Receptor B2; MIR10; ILT-4; ILT4; Leukocyte Immunogl
Species:
Cynomolgus
Source:
HEK293
Cat. No.: HY-P78478
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: LILRB2; Monocyte/Macrophage Immunoglobulin-Like Receptor 10; Leukocyte Immunoglobulin Like Receptor B2; CD85 Antigen-Like Family Member D; MIR-10; Myeloid Inhibitory Receptor 10; LIR-2; Leucocyte Ig-Like Receptor B2; MIR10; ILT-4; ILT4; Leukocyte Immunogl
Species:
Human
Source:
HEK293
Cat. No.: HY-P77737
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: LILRB2; Monocyte/Macrophage Immunoglobulin-Like Receptor 10; Leukocyte Immunoglobulin Like Receptor B2; CD85 Antigen-Like Family Member D; MIR-10; Myeloid Inhibitory Receptor 10; LIR-2; Leucocyte Ig-Like Receptor B2; MIR10; ILT-4; ILT4; Leukocyte Immunogl
Species:
Cynomolgus
Source:
HEK293
Cat. No.: HY-P78483
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: LILRB2; Monocyte/Macrophage Immunoglobulin-Like Receptor 10; Leukocyte Immunoglobulin Like Receptor B2; CD85 Antigen-Like Family Member D; MIR-10; Myeloid Inhibitory Receptor 10; LIR-2; Leucocyte Ig-Like Receptor B2; MIR10; ILT-4; ILT4; Leukocyte Immunogl
Species:
Human
Source:
HEK293
Cat. No.: HY-P72396
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: LILRB2; Monocyte/Macrophage Immunoglobulin-Like Receptor 10; Leukocyte Immunoglobulin Like Receptor B2; CD85 Antigen-Like Family Member D; MIR-10; Myeloid Inhibitory Receptor 10; LIR-2; Leucocyte Ig-Like Receptor B2; MIR10; ILT-4; ILT4; Leukocyte Immunogl
Species:
Human
Source:
HEK293
Cat. No.: HY-P70168
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: LILRB2; Monocyte/Macrophage Immunoglobulin-Like Receptor 10; Leukocyte Immunoglobulin Like Receptor B2; CD85 Antigen-Like Family Member D; MIR-10; Myeloid Inhibitory Receptor 10; LIR-2; Leucocyte Ig-Like Receptor B2; MIR10; ILT-4; ILT4; Leukocyte Immunogl
Species:
Human
Source:
HEK293
Cat. No.: HY-P992433
OR502 is a humanized IgG1 monoclonal antibody targeting LILRB2 (ILT4/CD85d), with a Kd value of 1.18 nM. OR502 binds to LILRB2 with high affinity and blocks its interaction with HLA class I ligands, relieving myeloid cell-mediated immunosuppression, restoring CD8 + T cell function, and reprogramming the immunosuppressive macrophage phenotype, thereby simultaneously enhancing both innate and adaptive antitumor immune responses. OR502 can be used in the research of cancers and advanced cancers (including melanoma, non-small cell lung cancer, sarcoma/soft tissue cancer, and urothelial carcinoma) .
Cat. No.: HY-RS07652
Target:
Research Areas:
LILRB2 Human Pre-designed siRNA Set A contains three designed siRNAs for LILRB2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P78841
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: LILRB2; Monocyte/Macrophage Immunoglobulin-Like Receptor 10; Leukocyte Immunoglobulin Like Receptor B2; CD85 Antigen-Like Family Member D; MIR-10; Myeloid Inhibitory Receptor 10; LIR-2; Leucocyte Ig-Like Receptor B2; MIR10; ILT-4; ILT4; Leukocyte Immunoglobulin-Like Receptor 2; LIR2; Immunoglobulin-Like Transcript 4; Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 2; Ig-Like Transcript 4; CD85d; CD85d Antigen; Leukocyte Immunoglobulin-Like Receptor, Subfamily B (With TM And ITIM Domains), Member 2
Species:
Human
Source:
HEK293
Cat. No.: HY-P78842
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: LILRB2; Monocyte/Macrophage Immunoglobulin-Like Receptor 10; Leukocyte Immunoglobulin Like Receptor B2; CD85 Antigen-Like Family Member D; MIR-10; Myeloid Inhibitory Receptor 10; LIR-2; Leucocyte Ig-Like Receptor B2; MIR10; ILT-4; ILT4; Leukocyte Immunoglobulin-Like Receptor 2; LIR2; Immunoglobulin-Like Transcript 4; Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 2; Ig-Like Transcript 4; CD85d; CD85d Antigen; Leukocyte Immunoglobulin-Like Receptor, Subfamily B (With TM And ITIM Domains), Member 2
Species:
Cynomolgus
Source:
HEK293
Cat. No.: HY-P704761
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: LILRB2; Monocyte/Macrophage Immunoglobulin-Like Receptor 10; Leukocyte Immunoglobulin Like Receptor B2; CD85 Antigen-Like Family Member D; MIR-10; Myeloid Inhibitory Receptor 10; LIR-2; Leucocyte Ig-Like Receptor B2; MIR10; ILT-4; ILT4; Leukocyte Immunoglobulin-Like Receptor 2; LIR2; Immunoglobulin-Like Transcript 4; Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 2; Ig-Like Transcript 4; CD85d; CD85d Antigen; Leukocyte Immunoglobulin-Like Receptor, Subfamily B (With TM And ITIM Domains), Member 2
Species:
Human
Source:
HEK293
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
