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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
13 Results for "
ITC
" in MedChemExpress (MCE) Product Catalog:
Products (13)
13 Results for "ITC" in MCE Product Catalog:
1
2-Phenylethyl isothiocyanate is a potent antifungal agent. 2-Phenylethyl isothiocyanate significantly inhibited spore germination and mycelial growth of Alternaria alternata, with a MIC (minimum inhibitory concentration) of 1.22 mM. The antifungal effect of 2-Phenylethyl isothiocyanate against Alternaria alternate might be via reduction in toxin content and breakdown of cell membrane integrity .
Cat. No.: HY-W540232
CAS No.: 2284-20-0
Synonyms: 4-Methylphenyl ITC
Research Areas:
4-Methoxyphenyl isothiocyanate (4-Methylphenyl ITC) is an antioxidant, with a IC50 value of 1.25 mM for scavenging DPPH radicals. ORAC testing indicates its antioxidant capacity as 11.7 mM TE (indicating that the antioxidant efficacy of this compound is equivalent to 11.7 mmol of Trolox (HY-101445, a standard antioxidant) under the same conditions), and it extends the oxidation process by approximately 9180 seconds in the Briggs–Rauscher reaction. Additionally, 4-Methoxyphenyl isothiocyanate exhibits moderate cholinesterase inhibitory activity, with an inhibition rate of 30.4% against acetylcholinesterase (AChE) and 17.9% against butyrylcholinesterase (BChE). 4-Methoxyphenyl isothiocyanate holds potential for research in the fields of antioxidation and neurological disorders .
Cat. No.: HY-23155S
CAS No.: 912627-98-6
Synonyms: 2-PE ITC-d5
Target:
Research Areas:
2-Phenylethyl isothiocyanate (Standard) is the analytical standard of 2-Phenylethyl isothiocyanate. This product is intended for research and analytical applications. 2-Phenylethyl isothiocyanate is a potent antifungal agent. 2-Phenylethyl isothiocyanate significantly inhibited spore germination and mycelial growth of Alternaria alternata, with a MIC (minimum inhibitory concentration) of 1.22 mM. The antifungal effect of 2-Phenylethyl isothiocyanate against Alternaria alternate might be via reduction in toxin content and breakdown of cell membrane integrity .
Cat. No.: HY-157126
CAS No.: 1616974-29-8
Synonyms: PTER-ITC
Pterostilbene-isothiocyanate (PTER-ITC) exhibits potent anticancereffects in vitro. Pterostilbene-isothiocyanate against human osteosarcoma cells by abrogating the β-catenin/TCF-4 interaction .
Cat. No.: HY-156440
Target:
Research Areas:
7-51A is a potent PB2 inhibitor with a KD value of 1.64 nM as determined by ITC. PB2 is an essential subunit of influenza RNA-dependent RNA polymerase (RdRP).
Cat. No.: HY-D0148
CAS No.: 288399-07-5
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Ru(bpy)2(phen-ITC)(PF6)2 is a multifunctional dye. Dyes are important tools in biological experiments. They can help researchers observe and analyze cell structures, track biomolecules, evaluate cell functions, distinguish cell types, detect biomolecules, study tissue pathology and monitor microorganisms. Their applications range from basic scientific research to clinical A wide range of diagnostics. Dyes are also widely used in traditional fields such as textile dyeing, as well as in emerging fields such as functional textile processing, food pigments and dye-sensitized solar cells.
Cat. No.: HY-142704
CAS No.: 2863623-98-5
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BRD4 D1-IN-1 is a selective BRD4 D1 inhibitor (IC50<0.092 µM). BRD4 D1-IN-1 has 18 nM affinity against BRD4 D1 and over 500-fold selectivity against BRD2 D1 and BRD4 D2 via ITC .
Cat. No.: HY-142705
CAS No.: 2863687-22-1
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BRD4 D1-IN-2 (compound 26) is a potent and selective BRD4 D1 inhibitor (IC50<0.092 µM). BRD4 D1-IN-2 has 15 nM affinity against BRD4 D1 and over 500-fold selectivity against BRD2 D1 and BRD4 D2 via ITC .
Cat. No.: HY-174842
CAS No.: 696643-14-8
Research Areas:
HTS05585 (Compound Hit-1) is a selective macrophage migration inhibitory factor (MIF) inhibitor with a Kd value of 0.29 μM measured by microscale thermophoresis (MST) and 0.32±0.01 μM verified by isothermal titration calorimetry (ITC). HTS05585 inhibits the release of pro-inflammatory factors (TNF-α, IL-6, IL-1β) from LPS-induced macrophages. HTS05585 is promising for research of inflammation-related diseases such as sepsis .
Cat. No.: HY-169679
CAS No.: 363160-12-7
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WAY-380153 (Compound 24) is an FKBP12 inhibitor. WAY-380153 exhibits moderate binding affinity for FKBP12, with a KD of 19 μM (measured by ITC) and 15 μM (measured by NMR). WAY-380153 can be used in research related to neurotrophy and neuroprotection .
Cat. No.: HY-W069974
CAS No.: 79932-56-2
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Ca2+-Langerin-IN-1 (Compound 3) is a allosteric Langerin inhibitor. Langerin is a C-type lectin that is expressed on Langerhans cells and plays a crucial role in pathogen recognition and innate immune activation. The KD value of the CRD domain of murine Langerin protein for Ca2+-Langerin-IN-1 is 17 μM under the presence of Ca²⁺ and 53 μM under the absence of Ca²⁺ competition. Ca2+-Langerin-IN-1 induces conformational changes and competitively replaces Ca²⁺, thereby inhibiting the carbohydrate recognition function of the protein. Ca2+-Langerin-IN-1 can be used in the research of immunomodulatory therapy .
Cat. No.: HY-121946
CAS No.: 35512-29-9
Synonyms: 4-(4-Chlorophenyl)imidazole
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Research Areas:
4-CPI (4-(4-Chlorophenyl)imidazole) is a CYP2B4 inhibitor with an IC50 of 0.11 μM and a Kd of 0.043 μM. The Ks of 4-CPI for cytochrome P450eryF (S93C/C154S mutant) is 9.4 μM, with no allosteric cooperative effect of ligand binding . 4-CPI binds to CYP2B4 at a 1:1 ratio, which induces substantial conformational changes in the enzyme's active pocket to form a closed crystal conformation (PDB:1SUO). 4-CPI can be used to investigate the flexibility of P450 active pockets, protein-ligand binding thermodynamics, and the allosteric mechanisms of P450 .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
