696643-14-8
Chemical Structure
HTS05585
- CAS No.: 696643-14-8
- Formula:C18H15N3O
- Molecular Weight:289.33
InChIKey: DBKOZDXYQZKMBC-UHFFFAOYSA-N
SMILES: CCC1=CC2=NC(C3=CC(C4=CC=CC=C4)=NO3)=CN2C=C1
Biological Activity: HTS05585 (Compound Hit-1) is a selective macrophage migration inhibitory factor (MIF) inhibitor with a Kd value of 0.29 μM measured by microscale thermophoresis (MST) and 0.32±0.01 μM verified by isothermal titration calorimetry (ITC). HTS05585 inhibits the release of pro-inflammatory factors (TNF-α, IL-6, IL-1β) from LPS-induced macrophages. HTS05585 is promising for research of inflammation-related diseases such as sepsis[1].
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HTS05585 | HTS05585 (Compound Hit-1) is a selective macrophage migration inhibitory factor (MIF) inhibitor with a Kd value of 0.29 μM measured by microscale thermophoresis (MST) and 0.32±0.01 μM verified by isothermal titration calorimetry (ITC). HTS05585 inhibits the release of pro-inflammatory factors (TNF-α, IL-6, IL-1β) from LPS-induced macrophages. HTS05585 is promising for research of inflammation-related diseases such as sepsis. | |||||||||||||||||||||
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Keywords
