Search Result

Results for "

Integrin β7

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Integrin (26) Drug Isomer (4)
By Research Areas:	Cancer (4) Infection (1) Inflammation/Immunology (23) Neurological Disease (4)

Inhibitors & Agonists

Inhibitory Antibodies

Recombinant Proteins

Antibodies

Targets Recommended: Integrin

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P9911

Vedolizumab 3 Publications Verification Anti-Human lymphocyte α4β7 Integrin, Humanized Antibody; LDP-02; MLN-002	Integrin	Inflammation/Immunology Cancer
Vedolizumab is a humanized IgG1 monoclonal antibody that targets the α4β7 *integrin* for the treatment of ulcerative colitis and Crohn's disease.

HY-P9984

Etrolizumab 2 Publications Verification rhuMAb Beta7; RG7413; PRO145223	Integrin	Cancer
Etrolizumab (rhuMAb Beta7) is a gut-selective, anti-β7 *integrin* monoclonal antibody. Etrolizumab is specific targeting of the β7 subunit of α4β7 and αEβ7 integrins with K_i values of 18 nM and 1800 pM for Human α4β7 and Human αEβ7-293, respectively. Etrolizumab can be used in research of inflammatory bowel disease (IBD) .

HY-177080

Emvistegrast GS-1427	Integrin	Inflammation/Immunology
Emvistegrast (GS-1427) is a quinolone derivative. Emvistegrast is also an inhibitor of *α4β7* integrin. Emvistegrast can be used to investigate diseases mediated by α4β7 integrin, such as inflammatory bowel disease .

HY-P9911A

*Vedolizumab (anti-α4β7-integrin)*	Integrin	Inflammation/Immunology
Vedolizumab (anti-α4β7-integrin) is a humanized IgG1 monoclonal antibody that targets the α4β7 *integrin* for the treatment of ulcerative colitis and Crohn's disease .

HY-15770

TR-14035 Maximum Cited Publications 6 Publications Verification	Integrin	Inflammation/Immunology
TR-14035 is a orally active dual **α₄β₇/α₄β₁ integrin antagonist, with IC₅₀** s of 7 nM and 87 nM for α₄β₇ and α₄β₁, respectively. TR-14035 can be used for the research of inflammation and autoimmune diseases .

HY-14951

Firategrast Maximum Cited Publications 6 Publications Verification SB 683699	Integrin	Neurological Disease
Firategrast (SB 683699) is an orally active and specific α4β1/α4β7 integrin antagonist. Firategrast reduces trafficking of lymphocytes into the central nervous system (CNS) and decreases multiple sclerosis (MS) activity .

HY-P990203

*Anti-Mouse LPAM-1/Integrin* α4β7 Antibody (DATK32)** 1 Publications Verification	Integrin	Inflammation/Immunology
Anti-Mouse LPAM-1/Integrin α4β7 Antibody (DATK32) is a rat-derived anti-LPAM-1/Integrin α4β7 IgG2a, κ type antibody inhibitor. Anti-Mouse LPAM-1/Integrin α4β7 Antibody (DATK32) specifically reacts with both chains of the *α4β7* heterodimer and blocks the adhesion to immobilized mucosal addressin cell adhesion molecule-1 (MAdCAM-1). Anti-Mouse LPAM-1/Integrin α4β7 Antibody (DATK32) suppresses the proliferation and cytokine secretion of CD8+ T cells. Anti-Mouse LPAM-1/Integrin α4β7 Antibody (DATK32) decreases Peyer’s patches and follicular B cells in mice. Anti-Mouse LPAM-1/Integrin α4β7 Antibody (DATK32) can be used for the researches of inflammation, such as ulcerative colitis .

HY-P990207

*Anti-Mouse/Human Integrin* β7 Antibody (FIB504)**	Integrin	Neurological Disease Inflammation/Immunology Cancer
Anti-Mouse/Human Integrin β7 Antibody (FIB504) is an anti-mouse/human Integrin β7 IgG2a monoclonal antibody. Anti-Mouse/Human Integrin β7 Antibody (FIB504) can reduce the residence of type 2 innate lymphoid cells (ILC2s). Anti-Mouse/Human Integrin β7 Antibody (FIB504) can be used for researches on inflammation conditions and cancer such as lupus nephritis and glioma .

HY-124290

Carotegrast methyl AJM300	Integrin	Inflammation/Immunology
Carotegrast methyl (AJM300) is an orally active and selective α4 integrin antagonist. HCA2969, an active metabolite of Carotegrast methyl, is a specific and dual α4β1/α4β7 integrin antagonist. Carotegrast methyl prevents the development of colitis in mice .

HY-75385

Zaurategrast ethyl ester CDP323; UCB1184197	Integrin	Inflammation/Immunology
Zaurategrast ethyl ester (CDP323), the ethyl ester proagent of CT7758 , is a *α4β1/α4β7* integrin antagonist used for the treatment of inflammatory and autoimmune disorders .

HY-138542

RO0270608	Integrin	Inflammation/Immunology
RO0270608, the active metabolite of R411, is a dual **alpha4beta1-alpha4beta7 (α4β1/α4β7)** integrin antagonist. Antiinflammatory activity .

HY-14190

Valategrast R-411 free base	Integrin	Inflammation/Immunology
Valategrast (R-411 free base) is a potent and orally active integrin α4β1 (VLA-4) and *α4β7* dual antagonist. Valategrast has the potential for Chronic obstructive pulmonary disease (COPD) and asthma treatment .

HY-129453

BOP sodium	Integrin	Inflammation/Immunology
BOP sodium is a potent and selective dual α9β1/α4β1 integrin inhibitor with K_d values in the picomolar range. BOP sodium shows the rapid and preferential mobilization of hematopoietic stem cell (HSC) and progenitors. BOP sodium has little inhibitory activity on α4β7, α1β1, α2β1, and α5β1, αIIBβ3 integrins .

HY-P99184

Abrilumab	Integrin	Infection Inflammation/Immunology Cancer
Abrilumab is a fully human monoclonal antibody directed against *α4β7. Abrilumab selectively binds the α4β7 integrin* heterodimer. Abrilumab can be used for the research of inflammatory bowel disease (IBD) .

HY-159179

*α4 integrin* receptor antagonist 3**	Integrin	Inflammation/Immunology
α4 integrin receptor antagonist 3 (Compound 11) is an orally active α₄integrin receptor antagonist. α4 integrin receptor antagonist 3 can inhibit the adhesion of K562 cells mediated by the interaction between α₄β₁/VCAM-1 and *α₄β₇/MAdCAM-1, with IC₅₀* values of 130 nM and 2 nM, respectively. α4 integrin receptor antagonist 3 has the potential to be used in the study of dextran sulfate sodium (DSS) colitis mouse model .

HY-177961

*α4β7 Integrin-IN-1*	Integrin	Inflammation/Immunology
α4β7 Integrin-IN-1 (Example 356) is a potent inhibitor of *α4β7* integrin (integrin). Its ability to block the interaction between α4β7 integrin and MadCAM-1 (EC₅₀) is 0.05 nM. α4β7 Integrin-IN-1 can be used for the study of inflammatory bowel disease .

HY-75385A

Zaurategrast ethyl ester sulfate CDP323 sulfate; UCB1184197 sulfate	Integrin	Inflammation/Immunology
Zaurategrast ethyl ester sulfate (CDP323 sulfate), the ethyl ester proagent of CT7758 , is a *α4β1/α4β7* integrin antagonist used for the treatment of inflammatory and autoimmune disorders .

HY-124290A

Carotegrast methyl hydrochloride AJM300 hydrochloride	Integrin	Inflammation/Immunology
Carotegrast methyl (AJM300) hydrochloride is an orally active and selective α4 integrin antagonist. HCA2969, an active metabolite of Carotegrast methyl hydrochloride, is a specific and dual α4β1/α4β7 integrin antagonist. Carotegrast methyl hydrochloride prevents the development of colitis in mice .

HY-185350

*α4β7 Integrin-IN-2*	Integrin	Inflammation/Immunology
α4β7 Integrin-IN-2 is an inhibitor of human α4β7 integrin with an IC₅₀ <5 nM. α4β7 Integrin-IN-2 modulates α4β7 integrin-mediated biological pathways. α4β7 Integrin-IN-2 can be used for the research of inflammatory dieases .

HY-14189

Valategrast hydrochloride R-411	Integrin	Inflammation/Immunology
Valategrast hydrochloride (R-411) is a potent integrin α4β1 (VLA-4) and *α4β7* dual antagonist. Valategrast hydrochloride has the potential for Chronic obstructive pulmonary disease (COPD) and asthma treatment .

HY-114225

TBC-4746	Integrin	Neurological Disease Inflammation/Immunology
TBC-4746 is a *α4β1/α4β7* integrin antagonist. TBC-4746 can be used in the research of asthma and multiple sclerosis .

HY-177080B

Emvistegrast axial isomer GS-1427 axial isomer	Drug Isomer Integrin	Inflammation/Immunology
Emvistegrast (GS-1427) axial isomer is an axial isomer of Emvistegrast (HY-177080). Emvistegrast axial isomer is an **integrin α4β7** inhibtor .

HY-177080A

(S,R)-Emvistegrast (S,R)-GS-1427	Drug Isomer Integrin	Inflammation/Immunology
(S,R)-Emvistegrast ((S,R)-GS-1427) is an isomer of Emvistegrast (HY-177080). (S,R)-Emvistegrast is an **integrin α4β7** inhibtor .

HY-186079

Deethyl-emvistegrast	Integrin	Inflammation/Immunology
Deethyl-emvistegrast is a quinoline derivative and also a *α4β7* integrin inhibitor. Deethyl-emvistegrast is the hydrolytic product of Emvistegrast (HY-177080). Deethyl-emvistegrast modulates inflammatory pathways. Deethyl-emvistegrast can be used in research related to inflammatory bowel disease (Crohn's disease and ulcerative colitis) .

HY-14190A

(rac)-Valategrast (rac)-R-411 free base	Drug Isomer	Others
(rac)-Valategrast ((rac)-R-411 free base) is a racemic compound of Valategrast (HY-14190). Valategrast is a potent, orally active dual antagonist of integrin α4β1 (VLA-4) and *α4β7*. Valategrast may be used in research on chronic obstructive pulmonary disease (COPD) and asthma.

HY-186079A

(S)-Deethyl-emvistegrast	Drug Isomer Integrin	Inflammation/Immunology
(S)-Deethyl-emvistegrast is the S-enantiomer of Deethyl-emvistegrast (HY-186079). Deethyl-emvistegrast is a quinoline derivative and also a *α4β7* integrin inhibitor. It acts as the hydrolysis product of Emvistegrast (HY-177080). Deethyl-emvistegrast modulates inflammatory pathways and can be used in research related to inflammatory bowel diseases (Crohn's disease and ulcerative colitis) .

HY-171216

GW559090	Integrin	Neurological Disease
GW559090 is a selective, competitive, and high-affinity α4 integrin antagonist with a K_d of 0.19 nM for α4β1. GW559090 can effectively block the binding of α4β1 to vascular cell adhesion molecule 1 (VCAM-1) and fibronectin with IC₅₀ values of 7.72 and 8.04 nM. GW559090 also inhibits the interaction between α4β7 and mucosal addressin cell adhesion molecule 1 (MAdCAM-1) (IC₅₀ = 23 nM). GW559090 can inhibit inflammatory infiltration in the eyes, repair the corneal barrier and restore the function of goblet cells. GW559090 can be used for research of Sjögren's syndrome associated dry eye .

Cat. No.	Product Name	Target	Research Area	Image

HY-P9911

Vedolizumab 3 Publications Verification Anti-Human lymphocyte α4β7 Integrin, Humanized Antibody; LDP-02; MLN-002	Integrin	Inflammation/Immunology Cancer
Vedolizumab is a humanized IgG1 monoclonal antibody that targets the α4β7 *integrin* for the treatment of ulcerative colitis and Crohn's disease.

HY-P9984

Etrolizumab 2 Publications Verification rhuMAb Beta7; RG7413; PRO145223	Integrin	Cancer
Etrolizumab (rhuMAb Beta7) is a gut-selective, anti-β7 *integrin* monoclonal antibody. Etrolizumab is specific targeting of the β7 subunit of α4β7 and αEβ7 integrins with K_i values of 18 nM and 1800 pM for Human α4β7 and Human αEβ7-293, respectively. Etrolizumab can be used in research of inflammatory bowel disease (IBD) .

HY-P9911A

*Vedolizumab (anti-α4β7-integrin)*	Integrin	Inflammation/Immunology
Vedolizumab (anti-α4β7-integrin) is a humanized IgG1 monoclonal antibody that targets the α4β7 *integrin* for the treatment of ulcerative colitis and Crohn's disease .

HY-P990203

*Anti-Mouse LPAM-1/Integrin* α4β7 Antibody (DATK32)** 1 Publications Verification	Integrin	Inflammation/Immunology
Anti-Mouse LPAM-1/Integrin α4β7 Antibody (DATK32) is a rat-derived anti-LPAM-1/Integrin α4β7 IgG2a, κ type antibody inhibitor. Anti-Mouse LPAM-1/Integrin α4β7 Antibody (DATK32) specifically reacts with both chains of the *α4β7* heterodimer and blocks the adhesion to immobilized mucosal addressin cell adhesion molecule-1 (MAdCAM-1). Anti-Mouse LPAM-1/Integrin α4β7 Antibody (DATK32) suppresses the proliferation and cytokine secretion of CD8+ T cells. Anti-Mouse LPAM-1/Integrin α4β7 Antibody (DATK32) decreases Peyer’s patches and follicular B cells in mice. Anti-Mouse LPAM-1/Integrin α4β7 Antibody (DATK32) can be used for the researches of inflammation, such as ulcerative colitis .

HY-P990207

*Anti-Mouse/Human Integrin* β7 Antibody (FIB504)**	Integrin	Neurological Disease Inflammation/Immunology Cancer
Anti-Mouse/Human Integrin β7 Antibody (FIB504) is an anti-mouse/human Integrin β7 IgG2a monoclonal antibody. Anti-Mouse/Human Integrin β7 Antibody (FIB504) can reduce the residence of type 2 innate lymphoid cells (ILC2s). Anti-Mouse/Human Integrin β7 Antibody (FIB504) can be used for researches on inflammation conditions and cancer such as lupus nephritis and glioma .

HY-P99184

Abrilumab	Integrin	Infection Inflammation/Immunology Cancer
Abrilumab is a fully human monoclonal antibody directed against *α4β7. Abrilumab selectively binds the α4β7 integrin* heterodimer. Abrilumab can be used for the research of inflammatory bowel disease (IBD) .

Species:	Human (3) Mouse (1) Cynomolgus (2)
Tag:	His (6)
Source:	HEK293 (5) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P705451

	Integrin alpha E beta 7 Protein, Human (HEK293, His) Integrin alpha E beta 7; ITGAE&ITGB7	Human	HEK293

HY-P705454

	Integrin alpha E beta 7 Protein, Cynomolgus (HEK293, His) Integrin alpha E beta 7; ITGAE&ITGB7	Cynomolgus	HEK293

HY-P705452

	Integrin alpha E beta 7 Protein, Mouse (HEK293, His) Integrin alpha E beta 7; ITGAE&ITGB7	Mouse	HEK293

HY-P704171

	Integrin alpha IV beta 7 Protein, Cynomolgus (HEK293, His) Integrin alpha 4 beta 7,ITGA4&ITGB7	Cynomolgus	HEK293

HY-P704170

	Integrin alpha IV beta 7 Protein, Human (HEK293, Tag free-His) Integrin alpha 4 beta 7; ITGA4&ITGB7	Human	HEK293

HY-P704865

	ITGB7 Protein, Human (His) Integrin beta-7; ITGB7; Gut homing receptor beta subunit	Human	E. coli

Compare Products


Products	In-stock - + Add to Cart
Cat. No.
Species
Source
Tag
Accession
Gene ID
Molecular Weight
Purity
Endotoxin Level
Biological Activity
Appearance
Formulation
Storage & Stability
Shipping
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Host:	Mouse (1) Rat (1)
Reactivity:	Human (1) mouse (1)
Application:	IHC-P (1) ICC/IF (1) IP (1) WB (1) FC (2) ELISA (1)
Isotype:	IgG (1) IgG1 (1)
Conjugation:	Non-conjugated (2)
Modification:	Unmodified (1)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P810191

	Integrin β7/ITGB7 Antibody (YA9535)	WB, IP, FC	mouse
	Integrin β7/ITGB7 Antibody (YA9535) is a Rat-derived and non-conjugated IgG monoclonal antibody, targeting to Integrin β7/ITGB7.

HY-P84217A

	ITGB7 Antibody (YA3914)(PBS only) Integrin beta-7, Integrin beta-P, M290 IEL antigen, Itgb7	IHC-P, ICC/IF, FC, ELISA	Human
	ITGB7 Antibody (YA3914) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to ITGB7.

Compare Products


Products	In-stock - + Add to Cart
Cat. No.
Host
Reactivity
Application
Dilution Ratio
Molecular Weight
Conjugation
Clonality
Immunogen
Appearance
Isotype
Gene ID
SwissProt ID
Purity
Formulation
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent: