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Isoforms Recommended:	KDM4

Results for "

KDM4B

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (2) CMV (1) Histone Demethylase (8) HSV (1) PROTACs (1) Reference Standards (2) Small Interfering RNA (siRNA) (3)
By Research Areas:	Cancer (8)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Inhibitors & Agonists

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-104048

QC6352 Maximum Cited Publications 11 Publications Verification	Histone Demethylase	Cancer
QC6352 is an orally active *KDM4* inhibitor with anti-tumor and anti-proliferative activity. QC6352 has in vivo inhibitory effects on PDX models of breast and colon cancer and reduces the number of chemoresistant cell populations. QC6352 inhibits *KDM4* different isoforms with IC₅₀s of 104 nM (KDM4A), 56 nM (KDM4B), 35 nM (KDM4C), and 104 nM (KDM4D), respectively. QC6352 has moderate inhibitory activity against *KDM5* with an IC₅₀ of 750 nM (KDM5B) .

HY-12725

ML324 5+ Cited Publications	Histone Demethylase HSV CMV	Cancer
ML324 is a potent JMJD2 demethylase inhibitor with antiviral activity. ML324 also exhibits inhibition for the histone demethylase *KDM4B, with an IC₅₀* of 4.9 μM. ML324 has potent anti-viral activity against both herpes simplex virus (HSV) and human cytomegalovirus (hCMV) infection via inhibition viral IE gene expression .

HY-101799

NCGC00244536 2 Publications Verification KDM4B Inhibitor B3	Histone Demethylase	Cancer
NCGC00244536 is a potent *KDM4B* inhibitor with an IC₅₀ of 10 nM.

HY-148807

Zavondemstat QC8222 free base; TACH 101 free base	Histone Demethylase Apoptosis	Cancer
Zavondemstat (QC8222 free base; TACH 101 free base) is an orally active pan-KDM4 inhibitor, with a IC₅₀ ≤ 0.08 μM against human KDM4A-D and a Kᵢ of 0.52 μM against human KDM4C. Zavondemstat induces cell apoptosis, causes S-phase cell cycle arrest, reduces the population of tumor-initiating cells and inhibits cancer cell proliferation. Zavondemstat suppresses tumor growth and induces tumor regression in mouse xenograft models. Zavondemstat can be used for the research of various cancers including colorectal cancer, esophageal squamous cell carcinoma and triple-negative breast cancer .

HY-110154

NSC636819	Histone Demethylase	Cancer
NSC636819 is a competitive and selective inhibitor of *KDM4A/KDM4B. KDM4A/KDM4B* are potential progression factors for prostate cancer. NSC636819 has the potential for the research of cancer diseases, especially prostate cancer .

HY-RS07214

KDM4B Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
KDM4B Human Pre-designed siRNA Set A contains three designed siRNAs for KDM4B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

KDM4B Human Pre-designed siRNA Set A KDM4B Human Pre-designed siRNA Set A

HY-RS23577

Kdm4b Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Kdm4b Rat Pre-designed siRNA Set A contains three designed siRNAs for Kdm4b gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Kdm4b Rat Pre-designed siRNA Set A Kdm4b Rat Pre-designed siRNA Set A

HY-RS17132

Kdm4b Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Kdm4b Mouse Pre-designed siRNA Set A contains three designed siRNAs for Kdm4b gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Kdm4b Mouse Pre-designed siRNA Set A Kdm4b Mouse Pre-designed siRNA Set A

HY-101799R

NCGC00244536 (Standard) KDM4B Inhibitor B3 (Standard)	Reference Standards Histone Demethylase	Cancer
NCGC00244536 (Standard) (KDM4B Inhibitor B3 (Standard)) is the analytical standard of NCGC00244536 (HY-101799). This product is intended for research and analytical applications. NCGC00244536 is a potent KDM4B inhibitor with an IC₅₀ of 10 nM.

HY-173135

*PROTAC KDM4* degrader-1**	PROTACs Histone Demethylase Apoptosis	Cancer
PROTAC KDM4 degrader-1 is a *KDM4* PROTAC degrader that degrades *KDM4A-C* with DC₅₀ values of 37.53, 39.93, and 49.41 nM, respectively, while sparing KDM4D. PROTAC KDM4 degrader-1 induces cell cycle arrest, apoptosis and antiproliferative activity in esophageal cancer cells. PROTAC KDM4 degrader-1 can be used for the research of esophageal cancer .

HY-104048R

QC6352 (Standard)	Reference Standards Histone Demethylase	Cancer
QC6352 (Standard) is the analytical standard of QC6352 (HY-104048). This product is intended for research and analytical applications. QC6352 is an orally active KDM4 inhibitor with anti-tumor and anti-proliferative activity. QC6352 has in vivo inhibitory effects on PDX models of breast and colon cancer and reduces the number of chemoresistant cell populations. QC6352 inhibits KDM4 different isoforms with IC₅₀s of 104 nM (KDM4A), 56 nM (KDM4B), 35 nM (KDM4C), and 104 nM (KDM4D), respectively. QC6352 has moderate inhibitory activity against KDM5 with an IC₅₀ of 750 nM (KDM5B) .

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P82791

	KDM4B Antibody (YA2536) KDM4B; JHDM3B; JMJD2B; KIAA0876; Lysine-specific demethylase 4B; JmjC domain-containing histone demethylation protein 3B; Jumonji domain-containing protein 2B	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat
	KDM4B Antibody (YA2536) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to KDM4B.

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KDM4B Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
KDM4B Human Pre-designed siRNA Set A contains three designed siRNAs for KDM4B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Kdm4b Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Kdm4b Rat Pre-designed siRNA Set A contains three designed siRNAs for Kdm4b gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Kdm4b Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Kdm4b Mouse Pre-designed siRNA Set A contains three designed siRNAs for Kdm4b gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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