5 Results for "

Kallikrein-IN-2

" in MedChemExpress (MCE) Product Catalog:
Products (5)

5 Results for "Kallikrein-IN-2" in MCE Product Catalog:

Cat. No.: HY-143867
CAS No.: 2702983-84-2
Target:  

Ser/Thr Protease

Research Areas:  

Others

Kallikrein-IN-2 (compound 1) is a Kallikrein inhibitor .
loading...
    loading...
Cat. No.: HY-P991015
CAS No.: 2921676-04-0
Synonyms: JNJ-78278343; KLCB-245

Target:  

CD3

Research Areas:  

Cancer

Pasritamig (JNJ-78278343; KLCB-245) is a bispecific T-cell engager (BiTE) that targets the complex of human kallikrein KLK2 and CD3 receptor. Pasritamig redirects the cytotoxicity of T cells to KLK2-expressing tumor cells and induces T cell-mediated lysis of KLK2-expressing prostate cancer cells. Administered via subcutaneous injection, subcutaneous infusion or intravenous infusion, Pasritamig exhibits antitumor activity against metastatic castration-resistant prostate cancer. Pasritamig has a safety profile with an extremely low incidence of cytokine release syndrome and can be safely administered in an outpatient setting. Pasritamig is applicable to the research of metastatic castration-resistant prostate cancer [2] .
loading...
    loading...
Cat. No.: HY-143476
Target:  

Kallikrein

Plasma kallikrein-IN-2 (Compound 198) is a potent plasma kallikrein (PKal) inhibitor with an IC50 of 0.1 nM. Plasma kallikrein-IN-2 can be used for hereditary angioedema, diabetic macular edema, and diabetic retinopathy research .
loading...
    loading...
Cat. No.: HY-122142A
CAS No.: 127428-47-1
Synonyms: S-2366 (hydrochloride)
Research Areas:  

Others

Pyr-​Pro-​Arg-​pNA (S-2366) hydrochloride is a chromogenic peptidyl substrate, and a noncompetitive inhibitor that occupies the active sites of FXIa and FXIa-LC to block factor IX activation. Pyr-​Pro-​Arg-​pNA hydrochloride functions as a hydrolyzable substrate for FXIa’s catalytic domain, human APC, murine APC, and purified plasma kallikrein .
loading...
    loading...
Cat. No.: HY-122142
CAS No.: 72194-57-1
Synonyms: S-2366
Pyr-​Pro-​Arg-​pNA (S-2366) is a chromogenic peptidyl substrate, and a noncompetitive inhibitor that occupies the active sites of FXIa and FXIa-LC to block factor IX activation. Pyr-​Pro-​Arg-​pNA functions as a hydrolyzable substrate for FXIa’s catalytic domain, human APC, murine APC, and purified plasma kallikrein .
loading...
    loading...